The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat
10.1016/j.shaw.2023.02.001
- Author:
Maryam ESFAHANI
1
;
Amir Hossein RAHBAR
;
Sara Soleimani ASL
;
Saed BASHIRIAN
;
Effat Sadat Mir MOEINI
;
Fereshteh MEHRI
Author Information
1. Nutrition Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
- Publication Type:Original article
- From:Safety and Health at Work
2023;14(1):118-123
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Chronic exposure to silica is related with the provocation of an inflammatory response and oxidative stress mechanism. Vitamin D has multiple benefits in biological activities particularly respiratory system disease.MethodIn this research, 20 male Wistar rats were randomly allocated into four groups (5 rats /group) as follow: Group1 received saline as (negative control) group. The group 2 received a single IT instillation of silica (positive control) group; the group 3 was co-administrated with single IT silica and Vitamin D (20 mg/kg/day) daily for a period of 90 days. The rats of group 4 received Vitamin D daily for a period of 90 days.
Results:Silica significantly increased serum and lung total Oxidant Status (TOS). Meanwhile, silica reduced serum and lung total antioxidant capacity (TAC), GSH and tumor necrosis factor-α (TNF-a). Vitamin D treatment meaningfully reversed oxidative stress, antioxidants status and inflammatory response. Also, Vitamin D improved histopathological changes caused by silica.
Conclusion:These findings indicate that Vitamin D exerts protective effects against silica-induced lung injury. It seems that Vitamin D has potential use as a therapeutic object for silica induced lung injure.
