The Effects of Propofol Anesthesia or Prophylactic Droperidol on Postoperative Nausea and Vomiting in Patients Undergoing a Gynecologic Laparoscopy.
10.4097/kjae.2001.40.3.348
- Author:
Shi Youn RHO
1
;
Sae Jin CHOI
Author Information
1. Department of Anesthesiology, College of Medicine, Chungnam National University, Daejeon, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Anesthetics, intravenous: propofol;
Pharmacology: droperidol;
Surgery: laparoscopy;
gynecologic;
Vomiting: nausea;
postoperative
- MeSH:
Anesthesia*;
Anesthesia, General;
Droperidol*;
Female;
Humans;
Incidence;
Laparoscopy*;
Postoperative Nausea and Vomiting*;
Postoperative Period;
Propofol*
- From:Korean Journal of Anesthesiology
2001;40(3):348-358
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Postoperative nausea and vomiting (PONV) is a common complication of a gynecologic laparoscopy. This study was designed to assess the effect of prophylactic droperidol 1 mg or propofol as the induction and maintenance anesthetic agent for prophylaxis of PONV in women undergoing a gynecologic laparoscopy. METHODS: Eighty ASA physical status 1, 2 patients undergoing an elective gynecologic laparoscopy were randomly allocated into four groups. Group 1 (n = 20) recieved an intravenous placebo of noraml saline 1 ml prior to induction of anesthesia and N2O-enflurane general anesthesia. Group 2 (n = 20) recieved an intravenous placebo of noraml saline 1 ml prior to induction of anesthesia and N2O-propofol general anesthesia. Group 3 (n = 20) recieved intravenous prophylactic droperidol 1 mg prior to induction of anesthesia and N2O-enflurane general anesthesia. Group 4 (n = 20) recieved intravenous prophylactic droperidol 1 mg prior to induction of anesthesia and N2O-propofol general anesthesia. RESULTS: The incidence and severity of PONV and sedation scores were assessed at 0, 30 min, 1, 3, 6, 24 and 48 hours postoperatively. The incidence of PONV was 75% in group 1, 10% in group 2, 30% in group 3 and 20% in group 4. The incidence of PONV during the first 6 hours postoperatively was 70% in group 1, 0% in group 2, 10% in group 3 and 5% in group 4 and there were no statistical differences among the four groups in the 6 to 24 hour postoperative period. Sedation scores were significantly higher in group 3 and 4 than in 1 and 2 in the 3 to 6 hour postoperative period. CONCLUSIONS: Propofol anesthesia, prophylactic droperidol 1 mg and a combination to prevent PONV were highly effective during the first 6 hours postoperatively.
