The Effect of Preemptive Local Infiltration of Lidocaine and Gabapentin on Postoperative Pain in Rats.
10.4097/kjae.2001.40.3.389
- Author:
Hae Kyu KIM
1
;
Hyun Sub LEE
;
Inn Se KIM
;
Seong Wan BAIK
;
Jae Young KWON
;
Sang Uk SHIN
Author Information
1. Department of Anesthesiology, College of Medicine, Pusan National University, Busan, Korea.
- Publication Type:Original Article
- Keywords:
Analgesia: preemptive;
Anesthetics, local: lidocaine;
Animals: rats;
Anticonvulsants: gabapentin
- MeSH:
Analgesia;
Animals;
Central Nervous System Sensitization;
Foot;
Humans;
Hyperalgesia;
Hypersensitivity;
Lidocaine*;
Male;
Pain, Postoperative*;
Rats*
- From:Korean Journal of Anesthesiology
2001;40(3):389-396
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Preemptive analgesia may improve postoperative antinociceptive treatment that prevents the development of central sensitization which contributes to post-injury pain hypersensitivity. However, beneficial effects of preemptive analgesia appear controversial. The purpose of this study was to examine the effect of pre- and post-incisional local infiltration of lidocaine and gabapentin on incisional pain in rats. METHODS: Thirty five male rats were divided into 7 groups; control group (n = 5), pre-lidocaine infiltration group (n = 5), post-lidocaine infiltration group (n = 5), pre-gabapentin 10 mg infiltration group (n = 5), post-gabapentin 10 mg infiltration group (n = 5), pre-gabapentin 30 mg infiltration group (n = 5), and post-gabapentin 30 mg infiltration group (n = 5). To evaluate postoperative mechanical hyperalgesia in injured feet, withdrawal thresholds were measured by calibrated von Frey filaments at 2 hrs, 1, 2, 3, 4, and 5 days after an incision. RESULTS: The pre-lidocaine infiltration group shows better analgesic effects than post-lidocaine infiltration group until postoperative day 1 (P < 0.05). The gabapentin infiltration groups were effective in postoperative pain management but there were no significant differences between pre- and post- incisional treatment. CONCLUSIONS: A preemptive lidocaine injection has a good analgesic effect on incisional pain. Gabapentin also has a good analgesic effect on incisional pain.
