Increased viral load in patients infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in the Republic of Korea
10.24171/j.phrp.2023.0024
- Author:
Jeong-Min KIM
1
;
Dongju KIM
;
Nam-Joo LEE
;
Sang Hee WOO
;
Jaehee LEE
;
Hyeokjin LEE
;
Ae Kyung PARK
;
Jeong-Ah KIM
;
Chae Young LEE
;
Il-Hwan KIM
;
Cheon Kwon YOO
;
Eun-Jin KIM
Author Information
1. Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea
- Publication Type:Original Article
- From:
Osong Public Health and Research Perspectives
2023;14(4):272-278
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objectives:Coronavirus disease 2019 (COVID-19) has been declared a global pandemic owingto the rapid spread of the causative agent, severe acute respiratory syndrome coronavirus 2.Its Delta and Omicron variants are more transmissible and pathogenic than other variants.Some debates have emerged on the mechanism of variants of concern. In the COVID-19 wave that began in December 2021, the Omicron variant, first reported in South Africa, became identifiable in most cases globally. The aim of this study was to provide data to inform effective responses to the transmission of the Omicron variant.
Methods:The Delta variant and the spike protein D614G mutant were compared with the Omicron variant. Viral loads from 5 days after symptom onset were compared usingepidemiological data collected at the time of diagnosis.
Results:The Omicron variant exhibited a higher viral load than other variants, resulting in greater transmissibility within 5 days of symptom onset.
Conclusion:Future research should focus on vaccine efficacy against the Omicron variant and compare trends in disease severity associated with its high viral load.
