Beta Thalassemia Presenting with Neonatal Cholestasis and Extensive Hemosiderosis: A Case Report
- Author:
Chung Gang JUNG
1
;
Jang Hoon LEE
;
Yu Bin KIM
Author Information
- Publication Type:Case Report
- From:Neonatal Medicine 2023;30(4):102-107
- CountryRepublic of Korea
- Language:English
- Abstract: Neonatal cholestasis is caused by various forms of liver injury and has a complex etiological background. Among these, cases of severe cholestasis due to primary hemolytic disease are rare. Herein, we report a case in which thalassemia-induced severe hemolysis caused bile duct injury by hemosiderosis, with cholestasis occurring shortly after birth and lasting for >4 months. In addition, complete recovery of liver pathology was observed both biochemically and histologically. Hence, clinicians should consider hemolytic disease as a rare cause of neonatal cholestasis in the differential diagnosis of neonates as well as the advisability of conservative treatment based on case progression.
