Medulloblastoma and Familial Adenomatous Polyposis in a 24-year-old Female Patient: A Case Report of Turcot Syndrome.
- Author:
Soo In JEONG
1
;
Jung Min SUH
;
Ji Hyuk LEE
;
Hae Jung LEE
;
Jee Hyun LEE
;
Ki Woong SUNG
;
Hye Jung SONG
;
Yon Ho CHOE
Author Information
1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. cyh@smc.samsung.co.kr
- Publication Type:Case Report
- Keywords:
Turcot syndrome;
Medulloblastoma;
Familial adenomatous polyposis
- MeSH:
Adenomatous Polyposis Coli*;
Brain Neoplasms;
Colectomy;
Colon;
Colonic Neoplasms;
Colonoscopy;
Diarrhea;
Drug Therapy;
Enterocolitis, Pseudomembranous;
Fathers;
Female*;
Fever;
Gastrointestinal Hemorrhage;
Humans;
Medulloblastoma*;
Mucositis;
Polyps;
Radiotherapy;
Siblings;
Young Adult*
- From:Korean Journal of Pediatric Gastroenterology and Nutrition
2007;10(2):206-210
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Turcot syndrome is characterized by the concurrence of a primary neuroepithelial brain tumor and multiple colorectal polyposis. We report a case of a 24-year-old woman diagnosed with Turcot syndrome. At first, the patient was diagnosed as having a medulloblastoma after a tumorectomy of the 4th ventricle mass. The patient underwent radiotherapy and chemotherapy. After high-dose chemotherapy, neutropenic fever and severe mucositis developed. For an evaluation of the persistent hematochezia and diarrhea, a colonoscopy was performed. It revealed pseudomembranous colitis and multiple polyps in the entire colon. According to the family history, her father had undergone a total colectomy due to colon cancer and polyposis of the entire colon. Her brother also was found to have multiple polyps in the colon by a colonoscopy. The patient was diagnosed with Turcot syndrome.
