Anti-Melanogenic Dipeptides from a Cretaceous Jinju Formation Derived from Micromonospora sp.
- Author:
Rui JIANG
1
;
Soohyun UM
;
Hyeongju JEONG
;
Jeongwon SEO
;
Min HUH
;
Young Ran KIM
;
Kyuho MOON
Author Information
- Publication Type:Original Article
- From:Natural Product Sciences 2023;29(2):59-66
- CountryRepublic of Korea
- Language:English
- Abstract: The anti-melanogenic activity of 259 actinomycete strains was tested, and based on the results for the inhibition of mushroom tyrosinase activity and the reduction in melanin content, Micromonospora sp. JCS1 and JCS7 were selected as the strains with the highest anti-melanogenic potential. The activity-guided fractionation of extracts from JCS1 and JCS7 led to the isolation of the dipeptides cyclo(L-Phenyl alanine (Phe)-L-Proline (Pro)) (1) and cyclo(L-Tryptophan (Trp)-L-Proline (Pro)) (2). These two compounds were tested for their inhibition of mushroom tyrosinase by monitoring L-DOPA levels and melanin production. Cyclo(L-Phe-L-Pro) (1) and cyclo(L-Trp-L-Pro) (2) were thus confirmed to have the potential for use in functional whitening cosmetics containing actinomycete-derived secondary metabolites.
