Immune-mediated hemolysis after administration of human intravenous immunoglobulin in a dog: a case report
- Author:
Minji KIM
1
;
Youngju KIM
;
Hyeona BAE
;
Rankyung JUNG
;
Minjeong KANG
;
Sumin CHA
;
Kyu-Woan CHO
;
Dong-In JUNG
;
Do-Hyeon YU
Author Information
- Publication Type:Case Report
- From:Korean Journal of Veterinary Research 2023;63(3):e28-
- CountryRepublic of Korea
- Language:English
- Abstract: A 10-year-old spayed female Maltese presented with purpura and hematemesis. Initial laboratory evaluation revealed immune-mediated thrombocytopenia, but evidence of hemolytic anemia was not identified. Three milligrams of human intravenous immunoglobulin (hIVIG) was administered for 3 hours following prednisolone and mycophenolate mofetil. A pale mucous membrane was identified, and the packed cell volume decreased by 3%. Blood film examination revealed significant spherocytosis with auto-agglutination. Blood transfusions and immunosuppression were continued for 4 days, and hIVIG was discontinued. This report describes a case of increased immune-mediated hemolysis after hIVIG administration, possibly due to new-onset immune-mediated hemolytic anemia or enhanced immunogenicity.
