A Case of Interstitial Pneumonia in Patients with Psoriasis Treated with Methotrexate
- Author:
Seung Soo LEE
1
;
Dae-Lyong HA
;
Jun Young KIM
;
Yong Hyun JANG
;
Weon Ju LEE
;
Seok-Jong LEE
;
Kyung Duck PARK
Author Information
1. Department of Dermatology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea
- Publication Type:Case Report
- From:Korean Journal of Dermatology
2023;61(9):571-574
- CountryRepublic of Korea
- Language:English
-
Abstract:
Methotrexate (MTX) is commonly employed in the management of chronic inflammatory skin diseases. We report the case of a 73-year-old man who presented with a persistent cough lasting for 1 month. He had an 11-year history of psoriasis and had received MTX (10.0 mg/wk) over the past 21 months. High-resolution chest computed tomography revealed diffuse ground-glass opacities and bronchiectasis affecting both lung fields. Based on clinical and radiological assessments, the patient was diagnosed with MTX-induced interstitial pneumonia. Notably, significant clinical and radiological improvement was observed 1 month after the discontinuation of MTX and corticosteroid administration. Although some reports have demonstrated lung toxicity in patients receiving high-dose MTX therapy, cases of adverse pulmonary effects following low-dose treatment in patients with psoriasis are rare.This case report underscores the rarity of interstitial pneumonia in a patient with psoriasis undergoing MTX treatment in Korea.
