Botulinum A toxin for the treatment of focal hyperhidrosis: 5 cases.
- Author:
Song Ahm LEE
1
;
Kwang Taik KIM
;
Sung Min PARK
;
Bong Gyu JUNG
;
Hyoung Mook KIM
;
Kyung SUN
;
In Sung LEE
Author Information
1. Department of Thoracic and Cardiovascular Surgery, College of Medicine, Korea University, Seoul.
- Publication Type:Case Report
- Keywords:
Hyperhidrosis;
Toxin
- MeSH:
Adrenergic Fibers;
Autonomic Pathways;
Botulinum Toxins, Type A*;
Follow-Up Studies;
Humans;
Hyperhidrosis*;
Povidone-Iodine;
Sweat;
Sweat Glands;
Sympathectomy
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2000;33(3):268-272
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Thoracic sympathicotomy has been used safely and successfully to treat essential hyperhidrosis. However, it has been difficult to treat compansatory hyperhidrosis after thoracic sympathicotomy and focal hyperhidrosis. The sweat glands were innervated by post-ganglionic sympathetic fibers with acetylcholic serving as the transmitter. Botulinum A toxin has been reported to block neuro-transmission at the cholinergic autonomic nerve terminals. Prospecting its effect for the sweat gland, we treated 5 patients with focal hyperhidrosis with botulinum A toxin. Three patients received bilateral thoracic sympathectomy (1 case) and sympathicotomy(2 case) via VAT. The hyperhidrosis area was marked with betadine and was subdivided into squares of 2x2 cm(4cm(2)) each. Botulinum A toxin was injected intracutaneously in a dosage of 2.5U/0.1ml(100U/4ml) /4cm(2). A total dose of 100U of Botulinum A toxin was injected into the affected sites. Subjective assessment of sweat production by the patients using a visual analogue scale showed a 20~70% improvement. During the follow-up period, no toxic effects were observed.
