Histologic evaluation of activity and chronicity of lupus nephritis and its clinical significance
- Author:
Sung-Eun CHOI
1
;
Agnes B. FOGO
;
Beom Jin LIM
Author Information
- Publication Type:Review Article
- From:Kidney Research and Clinical Practice 2023;42(2):166-173
- CountryRepublic of Korea
- Language:English
- Abstract: The National Institutes of Health (NIH) lupus nephritis activity and chronicity indices, which comprise six activity scores and four chronicity scores, have a long development history. The 2018 revised International Society of Nephrology/Renal Pathology Society classification for lupus nephritis adopted the most recent NIH indices to replace subclasses A, C, and A/C. Although an evidence-based approach should further evaluate the clinical significance of the modified NIH indices, recent validation studies demonstrated that the modified chronicity indices have a strong correlation with kidney outcome of lupus nephritis.
