Availability of erythrocyte sedimentation rate as a predictor of venom induced coagulopathy in patients with snakebite
- Author:
Han HEO
1
;
Hyung Jun MOON
;
Tae Yong SHIN
;
Dong Wook LEE
;
Dong Kil JEONG
;
Hyun Joon KIM
;
Hyun Jung LEE
Author Information
1. Department of Emergency Medicine, Soonchunhyang University Hospital, Cheonan, Korea
- Publication Type:Original Article
- From:Journal of the Korean Society of Emergency Medicine
2023;34(4):305-313
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Objective:Venom-induced coagulopathy (VIC) is a common snakebite complication that can cause life-threatening hemorrhage. Previous studies have shown that snake venom can cause a decrease in the erythrocyte sedimentation rate (ESR), but this has not been investigated in actual clinical practice. This study evaluated the clinical utility of erythrocyte sedimentation rate as a predictive factor for VIC in patients with a poisonous snakebite.
Methods:From January 2012 to December 2021, this study performed a retrospective study of patients with venomous snakebites presenting to a tertiary emergency department. The demographic and laboratory data were collected through a chart review. The patients were divided into two groups, VIC and NoVIC groups. Logistic regression analysis was performed to identify the factors that predicted the presence of VIC, and the receiver operating characteristic (ROC) curve was drawn.
Results:One hundred and fifty-three patients were enrolled, and 31 patients (20.3%) developed VIC. The VIC group had significantly lower ESR than the NoVIC group (5.1±5.6 vs. 14.8±13.8; P<0.001). Logistic regression analysis showed that the decreased ESR was associated with the occurrence of coagulopathy (odds ratio, 0.957; 95% confidence interval, 0.917-0.999; P=0.045). The area under the curve was 0.701 in the ROC curve, and the cutoff value was set to 4.5 mm/hr.
Conclusion:ESR measured upon arrival at the emergency department was available to predict venom-induced coagulopathy in snakebite patients.
