Effect of Vortioxetine on Alcohol Intake in C57BL/6 Mice
10.22802/jksbtp.2023.29.3.87
- Author:
Se Ra CHOI
1
;
Ji-Woon JEONG
;
Sung Young HUH
;
Byung-Uk JOO
;
Hyeon-Kyeong KIM
;
Sung-Gon KIM
Author Information
1. Department of Psychiatry, Pusan National University Yangsan Hospital, Yangsan, Korea
- Publication Type:Original Articles
- From:
Journal of the Korean Society of Biological Therapies in Psychiatry
2023;29(3):87-92
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objectives:The effectiveness of drugs currently used in medication, which is important in the treatment of alcohol use disorders, is limited. Recently, ondansetron which acts as 5-HT3 receptor antagonist, has been studied and proved possibility as new medication for alcohol use disorder. Meanwhile, there are studies supporting that 5-HT1A receptors are related to addictive behavior. Considering those studies, we expect that vortioxetine, which acts as both 5-HT3 receptor antagonist and 5-HT1A receptor agonist, may be effective in treatment of alcohol use disorder. The purpose of this study is to examine the effect of vortioxetine on alcohol intake of C57BL/6 mice.
Methods:In this study C57BL/6 mice were randomly assigned to normal saline group, vortioxetine 10 mg/kg group and vortioxetine 1 mg/kg group. To study effect of vortioxetine on alcohol, water, food intake and body weight of mice, we administered each medication for 14 days.
Results:The overall alcohol intake was different between the three groups (PGroup=0.021), and alcohol intake in vortioxetine 10 mg/kg group was significantly lower than one in placebo group. Change across time points (PTime<0.001) and the interaction between group and time (PGroup×Time =0.016) were also significant. However, there were no significant differences between the three groups in water, food intake and body weight.
Conclusions:These results indicated that administration of high dose vortioxetine reduced alcohol intake of mice.Therefore, it is necessary to conduct clinical studies to examine the effectiveness of vortioxetine as a new treatment for alcohol use disorder.
