Corneal Topographic Changes after Botulinum Toxin-A Injection in Patients with Essential Blepharospasm
10.3341/jkos.2023.64.9.845
- Author:
Sangyoon KIM
1
;
Jung Hyo AHN
Author Information
1. Department of Ophthalmology, Pusan National University Yangsan Hospital, School of Medicine, Pusan National University, Yangsan, Korea
- Publication Type:Original Article
- From:Journal of the Korean Ophthalmological Society
2023;64(9):845-850
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Purpose:To compare the corneal topographic change before and after botulinum toxin A injection in patients with essential blepharospasm.
Methods:From September 2015 to December 2020, we enrolled total 20 patients, 40 eyes diagnosed with essential blepharospasm. We estimated the corneal refractive power and astigmatism before and after Nabota® (Daewoong Co. Ltd, Seoul, Korea) botulinum toxin injection at 1 and 3 months using iTrace® Topography (Software version 4.2.1., Tracey technology Inc., Houston, TX, USA). Corneal refractive power was analyzed in superior, inferior, nasal and temporal location at 1 mm, 3 mm zone. Also, steep and flat keratometry, astigmatism was measured by topography.
Results:Corneal refractive power showed significant difference in superior and inferior location of 1 mm zone at 1 month after botulinum toxin injection (p = 0.038, p = 0.042). There was no significant difference in all four locations of 3 mm zone. At 1 month after toxin injection, steep keratometry was only significant reduced (p = 0.046) and with-the-rule astigmatism was shifted to against-the-rule astigmatism. At 3 months after toxin injection, keratometry and astigmatism was resolved to before toxin injection.
Conclusions:At 1 month after Nabota® (Daewoong Co. Ltd) botulinum toxin injection, corneal refractive power at vertical axis was flattened and steep keratometry was significantly reduced. At 3 months after toxin injection, corneal topographic change was changed to before toxin injection.
