Changes in Macular Thickness and Microvasculature in Koreans with Early Parkinson’s Disease
10.3341/jkos.2023.64.11.1055
- Author:
Lee Ha KWON
1
;
Yong Wun CHO
;
Seong-Jae KIM
;
Inyoung CHUNG
;
Woong Sun YOO
Author Information
1. Department of Ophthalmology, College of Medicine, Gyeongsang National University, Jinju, Korea
- Publication Type:Original Article
- From:Journal of the Korean Ophthalmological Society
2023;64(11):1055-1062
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Purpose:To investigate the thickness of the nerve fiber layer-ganglion cell inner plexiform layer (NFL-GCIPL) complex and microvascular macular changes in Korean patients with early Parkinson’s disease using optical coherence tomography (OCT) and OCT angiography (OCTA).
Methods:Forty-three eyes of 22 patients with early Parkinson’s disease were included. A control group of 20 patients (40 eyes) was also recruited. The thickness of the NFL-GCIPL macular complex was measured using OCT, and the densities of the superficial and deep macular retinal vessels were evaluated via OCTA in all subjects.
Results:The NFL-GCIPL thicknesses of the superior, inferior, temporal, and nasal sectors were 94.70 ± 9.35, 93.32 ± 9.16, 90.18 ± 6.32, and 93.11 ± 8.75 μm in the control group and 92.05 ± 4.96, 91.32 ± 7.48, 84.74 ± 6.82, and 91.32 ± 7.47 μm in the Parkinson’s disease group, respectively; all thicknesses were significantly greater in the control group. The superficial and deep retinal vessel densities did not differ between the two groups.
Conclusions:Neurodegenerative macular changes are more obvious than microvascular changes in patients with early Parkinson’s disease. Such neurodegenerative changes should be further evaluated in future cohort studies.
