Late side effects of bleomycin injection into the lower lip mucosa of a nine-year-old patient with venous malformation
10.5125/jkaoms.2023.49.5.304
- Author:
Kezia Rachellea MUSTAKIM
1
;
Soung Min KIM
Author Information
1. Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea
- Publication Type:BRIEF COMMUNICATION
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2023;49(5):304-307
- CountryRepublic of Korea
- Language:English
-
Abstract:
Venous malformation (VM) is a benign lesion of blood vessels caused by an error in vascular morphogenesis during the embryologic phase. This entity mostly affects the head and neck region, including the lips, tongue, buccal mucosa, gingiva, or palate. VM may cause functional and aesthetic impairments. The anatomical structure and shape of the lips provide an important aesthetic accent for an individual. Therefore, management of VM in the lip area without postoperative defects or scarring is challenging. In this brief communication article, we present a conservative approach to lip VM in a nine-year-old boy using a bleomycin injection that had good aesthetic and functional outcomes. Injection of 2 mL of 1/10 of 15 mg bleomycin in a saline dilution into the lip mucosa may present a drug reaction as a white plaque and reddish owl eye lesion that takes up to three weeks to resolve without a scar. It is important to recognize the characteristics and self-limiting nature of postoperative bleomycin complications to avoid unnecessary treatment.
