The Effect of Intravitreal Triamcinolone Acetonide and Bevacizumab Injection on Intraocular Pressure.
10.3341/jkos.2010.51.11.1491
- Author:
Jong seo PARK
1
;
Sung Woo HA
;
Seong Bae PARK
Author Information
1. Department of Ophthalmology, CHA University, CHA Bundang medical center, Seongnam, Korea. ophth75@hanmail.net
- Publication Type:Original Article
- Keywords:
Bevacizumab;
Intraocular pressure;
Triamcinolone acetonide
- MeSH:
Antibodies, Monoclonal, Humanized;
Humans;
Intraocular Pressure;
Intravitreal Injections;
Triamcinolone;
Triamcinolone Acetonide;
Bevacizumab
- From:Journal of the Korean Ophthalmological Society
2010;51(11):1491-1498
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To compare intraocular pressure (IOP) changes after intravitreal triamcinolone acetonide versus bevacizumab injection. METHODS: IOP was measured in 40 patients who received an intravitreal injection of 0.1 ml triamcinolone and 40 patients who received 2 consecutive intravitreal injections of bevacizumab (0.05 ml and 0.1 ml). Patients were divided into three groups : 0.1 ml triamcinolone group (0.1 IVTA group), 0.05 ml bevacizumab group (0.05 IVB group), and 0.1 ml bevacizumab group (0.1 IVB group). IOPs were compared within groups at different time points (before, 1 day after, and 30 days after the injection) and between groups at the same time points. RESULTS: In the 0.05 IVB and 0.1 IVB groups, IOP at 1 day after injection was significantly lower than before injection (P< 0.01, P = 0.03), and IOP at 30 days after injection was significantly higher than IOP at 1 day after injection (P < 0.01, P < 0.01). In the 0.1 IVTA group, IOP at 30 days after injection was significantly higher than before injection (P = 0.01). Between groups, IOP at 1 day after injection in the 0.05 IVB group was significantly lower than IOP in the 0.1 IVTA group (P = 0.03). CONCLUSIONS: IOP was decreased at 1 day after intravitreal bevacizumab injection, whereas in intravitreal triamcinolone acetonide IOP elevation persisted after 1 month.
