Intravascular NK/T-cell lymphoma: a case report and literature review
- Author:
Ji Min NA
1
;
Wookjae JUNG
;
Minhye KIM
;
Yun-Hong CHEON
;
Jong Sil LEE
;
Dae Hyun SONG
;
Jung Wook YANG
Author Information
- Publication Type:Case Study
- From:Journal of Pathology and Translational Medicine 2023;57(6):332-336
- CountryRepublic of Korea
- Language:English
- Abstract: Intravascular lymphoma is characterized by an exclusively intravascular distribution of tumor cells. Intravascular natural killer/T-cell lymphoma (IVNKTL) is extremely rare, highly aggressive, commonly Epstein-Barr virus (EBV)–positive, and predominantly affects the skin and central nervous system. Here we report a case of IVNKTL diagnosed in a 67-year-old female, presenting with persistent intermittent fever and skin rashes throughout the body. Incisional biopsy of an erythematous lesion on the chest exhibited aggregation of medium to large-sized atypical lymphoid cells confined to the lumen of small vessels that were positive for CD3, granzyme B, and CD56 on immunohistochemistry and EBV-encoded RNA in situ hybridization. EBV DNA was also detected in serum after diagnosis. With a review of 26 cases of IVNKTL to date, we suggest that active biopsy based on EBV DNA detection may facilitate early diagnosis of IVNKTL.
