Real-world Prescription Patterns and Patient Satisfaction Regarding Maintenance Therapy of Gastroesophageal Reflux Disease: An Observational, Cross-sectional, Multicenter Study
- Author:
Cheal Wung HUH
1
;
Nak Hoon SON
;
Young Hoon YOUN
;
Da Hyun JUNG
;
Min Kyung KIM
;
Eun Jeong GONG
;
Kyu Chan HUH
;
Seung Young KIM
;
Moo In PARK
;
Ju Yup LEE
;
Joong Goo KWON
;
Jae Hak KIM
;
Cheol Min SHIN
;
Kee Wook JUNG
;
Su Jin HONG
;
Hee Man KIM
;
Suck Chei CHOI
;
Hye-Kyung JUNG
;
Hyun Jin KIM
;
Kwang Jae LEE
Author Information
- Publication Type:Original Article
- From:Journal of Neurogastroenterology and Motility 2023;29(4):470-477
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background/Aims:Gastroesophageal reflux disease (GERD) is a common chronic gastrointestinal disorder that typically requires long-term maintenance therapy. However, little is known about patient preferences and satisfaction and real-world prescription patterns regarding maintenance therapy for GERD.
Methods:This observational, cross-sectional, multicenter study involved patients from 18 referral hospitals in Korea. We surveyed patients who had been prescribed proton pump inhibitors (PPIs) for GERD for at least 90 days with a minimum follow-up duration of 1 year. The main outcome was overall patient satisfaction with different maintenance therapy modalities.
Results:A total of 197 patients were enrolled. Overall patient satisfaction, patient preferences, and GERD health-related quality of life scores did not significantly differ among the maintenance therapy modality groups. However, the on-demand therapy group experienced a significantly longer disease duration than the continuous therapy group. The continuous therapy group demonstrated a lower level of awareness of potential adverse effects associated with PPIs than the on-demand therapy group but received higher doses of PPIs than the on-demand therapy group. The prescribed doses of PPIs also varied based on the phenotype of GERD, with higher doses prescribed for non-erosive reflux disease than erosive reflux disease.
Conclusion:Although overall patient satisfaction did not significantly differ among the different PPI maintenance therapy modality groups, awareness of potential adverse effects was significantly different between the on-demand and continuous therapy groups.
