Circulating Vitamin D Level and Risk of Sudden Cardiac Death and Cardiovascular Mortality:A Dose-Response Meta-Analysis of Prospective Studies
10.3346/jkms.2023.38.e260
- Author:
So Yeon KONG
1
;
Eujene JUNG
;
Seung-sik HWANG
;
Young Sun RO
;
Sang Do SHIN
;
Kyoung-chul CHA
;
Sung Oh HWANG
Author Information
1. Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea
- Publication Type:Original Article
- From:Journal of Korean Medical Science
2023;38(33):e260-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:We conducted a comprehensive meta-analysis of prospective cohort studies to analyze the effect of circulating vitamin D level on the risk of sudden cardiac death (SCD) and cardiovascular disease (CVD) mortality.
Methods:Prospective cohort studies evaluating the association between circulating vitamin D and risk of SCD and CVD mortality were systematically searched in the PubMed and Embase. Extracted data were analyzed using a random effects model and results were expressed in terms of hazard ratio (HR) and 95% confidence interval (CI). Restricted cubic spline analysis was used to estimate the dose-response relationships.
Results:Of the 1,321 records identified using the search strategy, a total of 19 cohort studies were included in the final meta-analysis. The pooled estimate of HR (95% CI) for low vs. high circulating vitamin D level was 1.75 (1.49–2.06) with I 2 value of 30.4%. In subgroup analysis, strong effects of circulating vitamin D were observed in healthy general population (pooled HR, 1.84; 95% CI, 1.43–2.38) and the clinical endpoint of SCD (pooled HRs, 2.68; 95% CI, 1.48– 4.83). The dose-response analysis at the reference level of < 50 nmol/L showed a significant negative association between circulating vitamin D and risk of SCD and CVD mortality.
Conclusion:Our meta-analysis of prospective cohort studies showed that lower circulating vitamin D level significantly increased the risk of SCD and CVD mortality.
