Baicalein Inhibits αα-Melanocyte-stimulating Hormonestimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells
10.15430/JCP.2023.28.2.40
- Author:
Min Chang OH
1
;
Pincha Devage Sameera MADUSHAN FERNANDO
;
Mei Jing PIAO
;
Kyoung Ah KANG
;
Herath Mudiyanselage Udari AKMINI HERATH
;
Jin Won HYUN
Author Information
1. Department of Biochemistry, Jeju National University College of Medicine, Jeju, Korea
- Publication Type:Original Article
- From:Journal of Cancer Prevention
2023;28(2):40-46
- CountryRepublic of Korea
- Language:English
-
Abstract:
Excessive UVB exposure causes development of both malignant and non-malignant melanoma via the secretion of α-melanocyte-stimulating hormone (α-MSH). We investigated whether baicalein (5,6,7-trihydroxyflavone) could inhibit α-MSH-stimulated melanogenesis. Baicalein prevented UVB- and α-MSH-induced melanin production and attenuated α-MSH-stimulated tyrosinase (monophenol monooxygenase) activity, and expression of tyrosinase and tyrosine-related protein-2. In addition, baicalein prevented melanogenesis and pigmentation via the p38 mitogen-activated protein kinases signaling pathway. These findings suggest that baicalein represents a natural compound for attenuating melanogenesis.
