Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases
- Author:
Byung Soo KONG
1
;
Changhan LEE
;
Young Min CHO
Author Information
- Publication Type:Review
- From:Diabetes & Metabolism Journal 2023;47(3):315-324
- CountryRepublic of Korea
- Language:English
- Abstract: Mitochondria are complex metabolic organelles with manifold pathophysiological implications in diabetes. Currently published mitochondrial-encoded peptides, which are expressed from the mitochondrial open reading frame of the 12S ribosomal RNA type-c (MOTS-c), 16S rRNA (humanin and short humanin like peptide 1-6 [SHLP1-6]), or small human mitochondrial open reading frame over serine tRNA (SHMOOSE) are associated with regulation of cellular metabolism and insulin action in age-related diseases, such as type 2 diabetes mellitus. This review focuses mainly on recent advances in MOTS-c research with regards to diabetes, including both type 1 and type 2. The emerging understanding of MOTS-c in diabetes may provide insight into the development of new therapies for diabetes and other age or senescence-related diseases.
