Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome
10.9758/cpn.2023.21.2.386
- Author:
Jae-Min KIM
1
;
Hee-Ju KANG
;
Ju-Wan KIM
;
Wonsuk CHOI
;
Sung-Wan KIM
;
Jung-Chul KIM
;
Byung Jo CHUN
;
Youngkeun AHN
;
Myung Ho JEONG
Author Information
1. Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
- Publication Type:Brief Report
- From:Clinical Psychopharmacology and Neuroscience
2023;21(2):386-390
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:We investigated effects of serum serotonin and interleukin 18 levels on suicidal ideation (SI) at acute and chronic phases of acute coronary syndrome (ACS).
Methods:Recent-onset 969 ACS patients were evaluated for serum serotonin and interleukin 18 levels; and SI by the“suicidal thoughts” item of the Montgomery–Åsberg Depression Rating Scale. After 1-year, 711 patients were re-evaluated for SI. Logistic regression models were used adjustment for potential covariates.
Results:Associations between serum interleukin 18 and SI at both phases were significant only in the lower serotonin group.
Conclusion:By evaluating serum serotonin and interleukin 18 levels, the clinical prediction of SI of ACS may be improved.
