Oxidative Stress and Inflammatory Biomarkers in People with Methamphetamine Use Disorder
- Author:
Çetin TURAN
1
;
Güliz ENORMANCI
;
Salim NEŞELIOĞLU
;
Yasemin BUDAK
;
Özcan EREL
;
Ömer ŞENORMANCI
Author Information
- Publication Type:Original Article
- From:Clinical Psychopharmacology and Neuroscience 2023;21(3):572-582
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:This study aimed to investigate the blood serum levels of biomarkers specifying oxidative stress status and systemic inflammation between people using methamphetamine (METH) and the control group (CG). Serum thiol/disulfide balance and ischemia-modified albumin levels were studied to determine oxidative stress, and serum interleukin-6 (IL-6) levels and complete blood count (CBC) were to assess inflammation.
Methods:Fifty patients with METH use disorder (MUD) and 36 CG participants were included in the study. Two tubes of venous blood samples were taken to measure oxidative stress, serum thiol/disulfide balance, ischemia-modified albumin, and IL-6 levels between groups. The correlation of parameters measuring oxidative stress and inflammation between groups with sociodemographic data was investigated.
Results:In this study, serum total thiol, free thiol levels, disulfideative thiol percentage ratios, and serum ischemia-modified albumin levels of the patients were statistically significantly higher than the healthy controls. No difference was observed between the groups in serum disulfide levels and serum IL-6 levels. Considering the regression analysis, only the duration of substance use was a statistically significant factor in explaining serum IL-6 levels. The parameters showing inflammation in the CBC were significantly higher in the patients than in the CG.
Conclusion:CBC can be used to evaluate systemic inflammation in patients with MUD. Parameters measuring thiol/disulfide homeostasis and ischemia-modified albumin can be, also, used to assess oxidative stress.
