Successful Early Lamotrigine and Aripiprazole Augmentation of Clomipramine in Severe Obsessive-compulsive Disorder
- Author:
Eun Hyun SEO
1
;
Seung-Gon KIM
;
Jae-Hon LEE
;
Hyung-Jun YOON
Author Information
- Publication Type:Case Report
- From:Clinical Psychopharmacology and Neuroscience 2023;21(3):604-608
- CountryRepublic of Korea
- Language:English
- Abstract: Lamotrigine and aripiprazole have shown efficacy as augmentation agents of serotonin reuptake inhibitors for treatment-resistant obsessive-compulsive disorder (OCD). To date, the efficacy of lamotrigine/aripiprazole augmentation has not been reported in OCD treatment. Herein, we report the case of a 37-year-old male with severe OCD and comorbid depression whose symptoms markedly improved after low-dose lamotrigine/aripiprazole augmentation to clomipramine.Our report suggests that early glutamatergic/antipsychotic augmentation contributes to rapid remission of OCD symptoms.
