1.Cephalometric analysis of mandibular growth in rabbits.
Hae Wook LEE ; Sung Tack KWON ; Chin Whan KIM
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1991;18(2):216-221
No abstract available.
Rabbits*
2.The effects of intraosseous saline infusion on hematologic parameters of rabbits.
Kyu Nam PARK ; Won Jae LEE ; Ju Il HWANG ; Kee Joong LEE ; Se Kyung KIM ; Byoung Ki KIM ; In Chul KIM
Journal of the Korean Society of Emergency Medicine 1992;3(2):10-15
No abstract available.
Rabbits*
3.EFFECTS OF METHODS AND DURATION OF PREFABRICATION ON THE MATURITY OF OSSEOUS FLAPS : AN EXPERIMENTAL STUDY IN RABBITS.
Jae Ho JEONG ; Hyo Hun KIM ; Byung Chul CHOI ; Sung Ho KIM ; Sang Hyun WOO ; Jung Hyun SEUL ; Jung Soo HONG
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1997;24(4):660-673
No abstract available.
Rabbits*
4.Recovery of the vestibular function after unilateral labyrinthectomy in rabbits.
Ki Hyeon ANN ; Hack Jun KANG ; Chul Ho JANG ; Jung Hun LEE ; Sang Won YOON ; Byung Rim PARK
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(5):929-935
No abstract available.
Rabbits*
5.The effect of tibial lengthening on the muscle in rabbits: A histopathologic and histomorphometric study.
Duk Yong LEE ; In Ho CHOI ; Chin Youb CHUNG ; Phil Hyun CHUNG ; Sug Jun KIM
The Journal of the Korean Orthopaedic Association 1993;28(3):1305-1319
No abstract available.
Rabbits*
6.Biocompatibility and Bone Conductivity of Porous Calcium Metaphosphate Blocks.
Yong Moo LEE ; Seok Young KIM ; Seung Yun SHIN ; Young KU ; In Chul RHYU ; Chong Pyoung CHUNG
The Journal of the Korean Academy of Periodontology 1998;28(4):559-567
While calcium phosphate ceramics meet some of the needs for bone replacement, they have some limitation of unresorbability and fibrous encapsulation without direct bone apposition during bone remodelling. To address these problem, we developed a new ceramic, calcium metaphosphate(CMP), and report herein the biologic response to CMP in subcutaneous tissue, muscle and bone. Porous CMP blocks were prepared by condensation of anhydrous Ca(H2PO4)2 to form non-crystalline Ca(PO3)2. Macroporous scaffolds were made using a polyurethane sponge method. CMP block possesses a macroporous structure with approximate pore size range of 0.3-1mm. CMP blocks were implanted in 8 mm sized calvarial defect, subcutaneous tissue and muscle of 6 Newzealand White rabbits and histologic observation were performed at 4 and 6 weeks later. CMP blocks in subcutaneous tissue and muscle were well adapted without any adverse tissue reaction and resorbed slowly and spontaneously. Histologic observation of calvarial defect at 4 and 6 weeks revealed that CMP matrix were mingled with and directly apposed to new bone without any intervention of fibrous connective tissue. CMP blocks didn't show any adverse tissue reaction and resorbed spontaneously also in calvarial defect. This result revealed that CMP had a high affinity for bone and was very biocompatible. From this preliminary result, it was suggested that CMP was a promising ceramic as a bone substitute and tissue engineering scaffold for bone formation.
Rabbits
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Animals
7.Exophytic bone formation using porous titanium membrane combined with pins in rabbit calvarium.
Young KIM ; Young Hyuk KWON ; Joon Bong PARK ; Yeek HERR ; Jong Hyuk CHUNG
The Journal of the Korean Academy of Periodontology 2006;36(2):273-288
The purpose of this study was to evaluate exophytically vertical bone formation in rabbit calvaria by the concept of guided bone regeneration with a custom-made porous titanium membrane combined with bone graft materials. For this purpose, a total of 12 rabbits were used, and decorticated calvaria were created with round carbide bur to promote bleeding and blood clot formation in the wound area. Porous titanium membranes (0.5 mm in pore diameter, 10 mm in one side, 2 mm in inner height) were placed on the decorticated calvaria, fixed with metal pins and covered with full-thickness flap. Experimental group I was treated as titanium membrane only. Experimental group II,III,IV was treated as titanium membrane with BBM, titanium membrane with DFDB and titanium membrane with FDB. The animals were sacrificed at 8 and 12 weeks after surgery, and new bone formation was assessed by histomorphometric as well as statistical analysis. 1. Porous titanium membrane was biocompatable and capable of maintaining the regeneration space. 2. At 8 and 12 weeks, all groups demonstrated exophytic bone formation and there was a statistical significant difference among different groups only at 12 weeks. 3. The DFDB group revealed the most new bone formation compared to other groups (p<0.05). 4. At 12 weeks, DFDB and FDB groups showed the most significant resorption of graft materials (p<0.05). 5. The BBM was not resorbed at all until 12 weeks. 6. The fixation metal pin revealed excellent effect in peripheral sealing. On the basis of these findings, we conclude that a porous titanium membrane may be used as an augmentation membrane for guided bone regeneration, and DFDB as an effective bone forming graft material. The fixation of the membrane with pin will be helpful in GBR technique. However, further study is required to examine their efficacy in the intraoral experiments.
Rabbits
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Animals
8.HgCl2 Toxicity on Cultured Renal Tubular Cells of Rabbit.
Jung Young LEE ; Seong Beom LEE ; Suk Hyung LEE ; Won Sang PARK ; Nam Jin YOO ; Sang Ho KIM ; Choo Soung KIM
Korean Journal of Pathology 1995;29(5):615-623
To understand the mechanism of cell injury when exposed to HgCl2, monitoring of cytosolic ionized free Ca2+([Ca2+]i), viability test, measurement of the amount of ATP, and Ca-ATPase activity were evaluated in cultured rabbit renal tubular cells(RTC) exposed to HgCl2. The results were as follows: 1) HgCl2 was cytotoxic to rabbit RTC at all doses except 10 uM and the rate of killing displayed a dose- and time-dependent relationship. 2) The absence of extracellular Ca provided partial protection from irreversible injury induced by HgCl2. 3) The increasing pattem of [Ca2+]i varied according to the concentrations of HgCl2. At the low concentrations of HgCl2 (2.5-10 microM), the level of [Ca2+]i increased slowly over the flat 2-3 min and then achieved plateau-state. In contrast, at the high concentrations of HgCl2 (25-100 microM) the level of [Ca2+]i achieved peak within 1 min and then decreased to a plateau state under normal concentrations. 4) The level of ATP was decreased to 27.5% of that of normal control cells within 3 min by using a treatment of 100 microM HgCl2. 5) HgCl2 did not affect the Ca2+ ATPase activity by enzyme histochemical observation. These findings suggest that the elevation of [Ca2+]i in response to the HgCl2-induced injury is an important event in accelerating injury that ultimately leads to cell death. But other possibilities such as HgCl2 might have direct deleterious effects on the also should be considered.
Rabbits
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10.A Study on the Pathogenesis of Renal Papillary Necrosis Induced by Endotoxin.
Kyung Rak SOHN ; Tae Joong SOHN
Korean Journal of Pathology 1989;23(4):416-454
The author carried out an experimentation to clarify a possible pathogenesis of renal papillary necrosis induced by an univisceral Shwartzman reaction. The experimental animals were healthy white rabbits in weighing between 1.7 kg and 3.0 kg. Under the condition of ureterostomy, animals were pretreated with 0.5 cc of 50% ethyl alcohol and followed by administration of 0.2 ~ 1.5 mg endotoxin (E. coli 026 : B6, bacto lipopolysaccharide B. Difco, U.S.A.) as preparation in the renal pelvis. And then sacrificed at 10 minutes, 30 minutes, 1 hour, 2 hours, 6 hours and 24 hours after intravenous injection of 0.2 mg or 0.6 mg endotoxin through the ear veins, subjection to examine light and electron microscopically. The obtained results were summarized as follows: Papillary necrosis was developed in 88% among 18 cases excluding 6 cases died before sacrification. There were two types of necrosis, namely papillary and medullary type, but the former and combined forms of both types were the most common findings. Initial main target site of injury in renal papilla induced by endotoxiin was the endothelium of vasa recta and then followed by the Henle's loop, interstitial cell and collecting tubule respectively. Vascular injuries such as swelling and detachment of endothelium were observed since 10 minutes after endotoxin injection. Henle's loop showed stratification of basement membrane without consistent features with time lapses and initially observed fatty vaculoes at 1 hour after endotoxin injection were more eminent in 24 hours group. Main changes of interstitial cells were decrease of lipid droplets while increase of fatty vacuoles; the latter were initially observed in 1 hour group and more eminent in 24 hours group. Collecting tubule showed many fatty vacuoles especially in 24 hours group. It is thought that emergence of fatty vacuoles seems to be a kind of immature lipid droplets to compensate the increased demand of PC release due to continuous ischemic condition. In conclusion, it is thought that ischemic injury due to the vascular changes is pathogenic mechanism producing renal papillary necrosis. Endotoxin induced univisceral Shwartzman reaction in the kidney may be a good experimental model in studying renal papillary necrosis.
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