1.Appropriate use of Prostate-Specific Antigen in Diagnosing Carcinoma of the Prostate.
Yun Sik KWAK ; Young Ae LIM ; Hee Sun JEON
Journal of the Korean Geriatrics Society 1997;1(1):12-17
No abstract available.
Prostate*
;
Prostate-Specific Antigen*
2.In Search of a New Prostate-Specific Antigen
International Neurourology Journal 2019;23(1):3-4
No abstract available.
Prostate-Specific Antigen
3.Multicenter Comparison of Four Automated Immunoassay Analyzers for Prostate Specific Antigen
Dong Jin PARK ; Yeongsic KIM ; Hae Kyung LEE ; Jehoon LEE ; Kyungja HAN ; Hi Jeong KWON
Annals of Laboratory Medicine 2019;39(4):406-410
No abstract available.
Immunoassay
;
Prostate
;
Prostate-Specific Antigen
4.The Factors Influencing the Percentage of Free Serum Prostate Specific Antigen Levels in Men without Clinically Detectable Prostate Cance.
Dae Young KIM ; Cheol KWAK ; Seung Bae LEE ; Eun Chan PARK ; Hyeon JEONG ; Sang Eun LEE
Korean Journal of Urology 2000;41(6):718-724
No abstract available.
Humans
;
Male
;
Prostate*
;
Prostate-Specific Antigen*
5.The Factors Influencing the Percentage of Free Serum Prostate Specific Antigen Levels in Men without Clinically Detectable Prostate Cance.
Dae Young KIM ; Cheol KWAK ; Seung Bae LEE ; Eun Chan PARK ; Hyeon JEONG ; Sang Eun LEE
Korean Journal of Urology 2000;41(6):718-724
No abstract available.
Humans
;
Male
;
Prostate*
;
Prostate-Specific Antigen*
6.The Effect on Serum Prostate Specific Antigen after Transurethral Resection of Prostate for Benign Prostate Hypertrophy.
Hee Jong JEUNG ; Bong Ryoul OH ; Jai Dong MOON
Korean Journal of Urology 1997;38(1):70-75
PURPOSE: It is important to know for transurethral resection of prostate (TURP) affecting the serum prostate specific antigen (PSA) value how long one should wait before being able to ~ obtain an accurate and meaningful serum PSA level. We evaluated the change of serum PSA concentration in patients with benign prostate hypertrophy(BPH) before and after TURP in association with time course and resected prostatic weight. MATERIALS AND METHOD: The effect of TURP was examined in 27 patients with BPH (mean age: 64 years; range: 55-79 years). The serum PSA levels were measured serially (before and 1, 3, 5, 7, 14, 30, 60, 90 days after TURP) by Abott IMX assay. RESULTS: The level of serum PSA appeared to be consistent with prostatic volume by transrectal ultrasonography(TRUS) and was elevated by about 0.16 ng/mL for each gram of hyperplastic tissue present (p=0.375, p=0.058). TURP caused an immediate elevation in the serum PSA concentration, with a median increase of 19 ng/mL (p=0.0001). The larger resected group showed a dramatic and statistically significant PSA rise immediately after TURP than the smaller resected group (p=0.023). From the 15 post-operative day, the PSA concentrations continued slightly lower than that of pre-operative day (p=0.0001), and was still decreased on 30 days (p=0.0001). The median time to return to a baseline level of PSA was 30 days (range: 1460 days) after TURP. CONCLUSION: These findings indicate that TURP caused an immediate increase in the serum PSA level, which generally return to stable, baseline level within 30 days. However, because in some patients the serum PSA still remained elevated than upper normal limit after 30 days, it is recommended that a serum PSA determination should be obtained for at least 60 days after TURP.
Humans
;
Hypertrophy*
;
Prostate*
;
Prostate-Specific Antigen*
;
Transurethral Resection of Prostate*
7.The Effect on Serum Prostate Specific Antigen after Transurethral Resection of Prostate for Benign Prostate Hypertrophy.
Hee Jong JEUNG ; Bong Ryoul OH ; Jai Dong MOON
Korean Journal of Urology 1997;38(1):70-75
PURPOSE: It is important to know for transurethral resection of prostate (TURP) affecting the serum prostate specific antigen (PSA) value how long one should wait before being able to ~ obtain an accurate and meaningful serum PSA level. We evaluated the change of serum PSA concentration in patients with benign prostate hypertrophy(BPH) before and after TURP in association with time course and resected prostatic weight. MATERIALS AND METHOD: The effect of TURP was examined in 27 patients with BPH (mean age: 64 years; range: 55-79 years). The serum PSA levels were measured serially (before and 1, 3, 5, 7, 14, 30, 60, 90 days after TURP) by Abott IMX assay. RESULTS: The level of serum PSA appeared to be consistent with prostatic volume by transrectal ultrasonography(TRUS) and was elevated by about 0.16 ng/mL for each gram of hyperplastic tissue present (p=0.375, p=0.058). TURP caused an immediate elevation in the serum PSA concentration, with a median increase of 19 ng/mL (p=0.0001). The larger resected group showed a dramatic and statistically significant PSA rise immediately after TURP than the smaller resected group (p=0.023). From the 15 post-operative day, the PSA concentrations continued slightly lower than that of pre-operative day (p=0.0001), and was still decreased on 30 days (p=0.0001). The median time to return to a baseline level of PSA was 30 days (range: 1460 days) after TURP. CONCLUSION: These findings indicate that TURP caused an immediate increase in the serum PSA level, which generally return to stable, baseline level within 30 days. However, because in some patients the serum PSA still remained elevated than upper normal limit after 30 days, it is recommended that a serum PSA determination should be obtained for at least 60 days after TURP.
Humans
;
Hypertrophy*
;
Prostate*
;
Prostate-Specific Antigen*
;
Transurethral Resection of Prostate*
8.The Relationship of Cellular Composition of Benign Prostatic Hyperplasia and Prostate-Specific Antigen (PSA) Levels.
Byung Ha CHUNG ; Bong Hyeon LEE ; Sung Joon HONG
Korean Journal of Urology 1996;37(10):1093-1096
The relationship between the serum values of prostate-specific antigen (PSA) and the histologic composition of benign prostatic hyperplasia (BPH) was investigated in 32 symptomatic BPH patients undergoing transurethral resection of the prostate. We evaluated the free and total PSA concentrations by ACS-PSA2 (Ciba-Corning) assay. The stereological analysis was made by computer aided-area densitometry using H & E stained slides to quantify stromal and glandular areas in the resected prostate tissue. The total PSA concentration versus percentage of glandular area (%G) and stromal-glandular ratio (SGR) correlated significantly (p<0.05 for both) whereas the free PSA concentration and free/total PSA ratio did not (p>0.05 for both). These data suggest that total PSA is directly correlated with the histologic composition of the prostate in men with BPH, however, the proportion of free to total PSA was not informative to predict the histology. Thus, pretreatment evaluation of total PSA would be useful as part of an evaluation method of BPH for medical therapy.
Densitometry
;
Humans
;
Male
;
Prostate
;
Prostate-Specific Antigen*
;
Prostatic Hyperplasia*
9.Prostate Cancer Detection Rate of Rebiopsy in Patients with an Initial Diagnosis of Atypical Small Acinar Proliferation of the Prostate.
Jung Woo OH ; Yun Beom KIM ; Seung Ok YANG ; Jeong Ki LEE ; Yoon Jung KIM ; Tae Young JUNG ; Hong Bang SHIM
Korean Journal of Urology 2009;50(3):237-240
PURPOSE: Atypical small acinar proliferation (ASAP) denotes the presence of suspicious glands with insufficient cytological architecture for a definitive prostate cancer diagnosis. We evaluated the subsequent prostate cancer detection rate of rebiopsy in patients with an initial diagnosis of ASAP. MATERIALS AND METHODS: Between January 2003 and December 2006, 1,416 men with suspected prostate cancer underwent a transrectal ultrasound-guided prostate biopsy, and 214 (15.1%) were diagnosed as having ASAP. Ninety-five of the 215 patients underwent at least one more biopsy. We evaluated the cancer detection rates after rebiopsy. RESULTS: In men with ASAP, 36 patients (37.9%) had prostate cancer. The cancer detection rates of the 1st, 2nd, and 3rd rebiopsies were 30.5%, 23.8%, and 40%, respectively. Mean patient age and prostate-specific antigen did not differ significantly between the prostate cancer and noncancer groups after rebiopsy. Prostate volume, however, was significantly smaller in the cancer group (p<0.05). CONCLUSIONS: Our results showed a detection rate for prostate cancer of 37.9% after an initial diagnosis of ASAP, which indicates that an initial diagnosis of ASAP mandates rebiopsy.
Biopsy
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Humans
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Male
;
Prostate
;
Prostate-Specific Antigen
;
Prostatic Neoplasms
10.The Prostate Cancer Detection Rate on the Second Prostate Biopsy according to Prostate-Specific Antigen Trend.
Hyung Sang KIM ; Chang Yong LEE ; Dong Hun LIM ; Chul Sung KIM ; Seung BAIK
Korean Journal of Urology 2012;53(10):686-690
PURPOSE: To identify the prostate cancer detection rate on the patients who had second prostate biopsy out of the patients who were reported negative in their first biopsy. MATERIALS AND METHODS: From July 2006 to February 2012, prostate biopsy was performed on 843 patients with over 4 ng/ml and on 618 biopsy negative patients PSA was performed from between 6 months and 9 months after biopsy. On 164 patients, second biopsy was performed, and 42 patients were selected. If there was less than 10% change between PSA before the prostate biopsy and PSA measured during 6 to 9 months after the first biopsy it was considered as no change. If above 10% increase, it was considered increase and if above 10% decrease it was considered as decrease. RESULTS: The cancer detection rate in PSA increase group was 20%, the detection rate in no change in PSA level but still over the normal range group 8.3%, and that in the PSA decrease group was 0%. When comparing prostate cancer group and non-cancer group, it is more probable to have prostate cancer when they are older, prostate volume is smaller and PSA density is higher. CONCLUSIONS: The second biopsy is strongly recommended when PSA level shows no change or increase, age is older, prostate volume is smaller or PSA density is higher.
Biopsy
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Humans
;
Prostate
;
Prostate-Specific Antigen
;
Prostatic Neoplasms
;
Reference Values