No abstract available.
Genome, Human* ; Human Genome Project* ; Humans ; Humans*

Recent rapid advances in genetic research are ushering us into the genome sequence era, where an individual's genome information is utilized for clinical practice. The most spectacular results of the human genome study have been provided by genome-wide association studies (GWASs). This is a review of the history of GWASs as related to my work. Further efforts are necessary to make full use of its potential power to medicine.
Genetic Research ; Genome ; Genome, Human ; Genome-Wide Association Study ; HapMap Project ; Human Genome Project ; Humans

China ; Human Genome Project ; Humans ; International Cooperation

Diagnosis, Differential ; Genome ; Human Genome Project ; Humans ; Medicine, Chinese Traditional

Genome ; Human Genome Project ; Humans ; Medicine, Chinese Traditional ; trends

The completion of the rough draft of the human genome is a remarkable achievement. It provides the overall structures of huge DNA molecules that constitute the genome and an outline of the information needed to create a human being This paper reviewed new ideas, projects, and scientific advances made by the Human Genome Project. We also discussed the future of medicine and biomedical research in postgenomic era.
DNA ; Genome ; Genome, Human* ; Genomics ; Human Genome Project* ; Humans ; Humans* ; Proteome ; Proteomics

Increasing rate of childhood obesity is one of the social health problems in Korea. The mechanisms of fat accumulation and maintenance are not clear yet. Genetic, environmental, behavioral and socioeconomic factors in individuals might cause very heterogenous phenotypic expressions of obesity. In the aspect of genetic factors, there are two types of obesity; monogenic (single mutations) and polygenic obesity (known as common obesity). The completion of human genome project contributed to genetic study for obesity and many candidate genes associated with obesity were found in the past couple of years. However, the functional study of those genes was little performed. The trials to reveal the effect of each gene are required, because the more genes are studied, the better the mechanisms of obesity can be understood.
Human Genome Project ; Humans ; Korea ; Obesity ; Socioeconomic Factors

Due to lack of appreciation of the complexities of the interactions between nature and nurture, claims for the rapid improvements in medical care following the human genome project have been exaggerated. Although some progress has been made in certain fields, the full scope of genomic medicine may not be realised for many years.
Genetics, Medical ; Genomics ; Global Health ; Human Genome Project ; Humans ; Metaphysics

The human genomic project and the international HapMap project were designed to create a genome-wide database of patterns of human genetic variation, with the expectation that these patterns would be useful for genetic association studies of common diseases, thus lead to molecular diagnosis and personnel therapy. The article briefly reviewed the creation, target and achievement of those two projects. Furthermore, the authors have given four suggestions in facing to the opportunities and challenges brought by the two projects, including cultivation improvement of elites, cross binding of multi-subjects, strengthening construction of research base and initiation of natural key scientific project.
Genome, Human ; Genomics ; HapMap Project ; Humans ; Oral Medicine

For the first time ever, the scientists of J. Craig Venter team have created actual self-replicating synthetic life. The research was just published in the Journal of Science on May 20, 2010. Although this news immediately brings the worry about the possible potential threat to biosecurity and biosafety as well as the ethical disputes, it yet indicates that mankind have made a new step forward in synthetic biology. In the time of post-genome era, we believe the advancement of synthetic biology that might affect or change the future life of human being will be widely used in energy, environment, materials, medication and many other fields.
Biological Science Disciplines ; methods ; Cloning, Organism ; Genome, Human ; genetics ; Human Genome Project ; Humans ; Synthetic Biology ; trends