OBJECTIVETo study the development of anterior fontanel(AF) in children less than 2 years of age.

METHODThe size of AF of the children under 2 years of age was measured. The criteria were: (1) All the children were singletons and term (37 weeks ≤ gestational age ≤ 40 weeks) at birth, birth weight > 2500 g. (3) Those with intracranial diseases (included trauma and asphyxia) and scalp hematoma were ruled out. (3) Healthy children (without intracranial disease, growth retardation, congenital syndrome or bone metabolic diseases such as rickets).

RESULT(1) The mean value of AF in neonates was 1.5 (0.3 - 2.5) cm, and the average of the AF at 1 month after birth was 2.2 cm, which was the largest one. The size of AF was 1.0 (0.3 - 2.0) cm at age 12 months, and 0.5 (0.3 - 0.7) cm at 24 months. (2) The percentage for the closure of the AF was 3% at 6 months, 26.5% at 12 months, and 93.0% at 24 months. (3) There were no gender differences in the size of the AF (P > 0.05). And the size of AF was not correlated with the development levels of weight, length, and head circumference (P > 0.05).

CONCLUSION(1) The size of AF at 1 month was maximum (2.2 cm), and then decreased by years. The AF was almost closed (93%) at 24 months. (2) There were no gender differences in anterior fontanel (P > 0.05). The size of AF was not correlated with the growth of weight, length, and head circumferences (P > 0.05). (3) The fontanel dimensions should be represented by oblique diameters of the fontanel in clinical pediatrics. (4) The AF closure time needs to be further evaluated in normal children.

Age Factors ; Birth Weight ; Body Height ; Body Weight ; Cephalometry ; methods ; Child Development ; Child, Preschool ; Cranial Fontanelles ; anatomy & histology ; growth & development ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Reference Values

OBJECTIVEAs the intrauterine environment can affect childhood growth and development, this study aims to understand the relationship between birth gestational age, birth weight and physique development in 9 to 15-year-old children by a cross sectional investigation in Chengdu City, Sichuan Province.

METHODSA total of 7194 9 to 15-year-old school children were classified according to birth gestational age and birth weight: small for gestational age (SGA), appropriate for gestational age (AGA) and large for gestational age (LGA). Their heights and weights were measured. Parents completed a questionnaire.

RESULTSThe prevalence of SGA was 6.23% (448 cases), and 5.13% of children in the SGA group did not undergo "catch-up growth" (lower than -2 SD). The mean height in these children at various stages was significantly lower than in the AGA group (P<0.05). The prevalence of LGA was 18.06% (1299 cases). A total of 179 children (13.78%) were found to be overweight and 57 children (4.39%) were found to be obese in the LGA group. The mean weight in the LGA group at various stages was significantly higher than in the AGA group (P<0.05).

CONCLUSIONSHeight and weight development in children born SGA and LGA are different from normal children. More attention should be given to aspects of height and weight development in these school children.

Adolescent ; Birth Weight ; Body Height ; Body Weight ; Child ; Child Development ; Female ; Humans ; Infant, Newborn ; Infant, Small for Gestational Age ; growth & development ; Male

Orthodontic patients are individuals that grow and develop : therefore selection of the proper time for orthodontic trdatment is considered to be one of the most difficult and yet difficult foctor. Since the development of cephalometric X-ray, amount and pattern of craniofacial growth change with aging could be predicted and became useful in the process of orthodontic treatment. The relationship between the mean values of cephalometric measurements and body helght and weight was studied among the groups(boys and girls) of Koream childern from the ages 0f 3-years to 12-years. 126 boys and 90 girls with no abnormality in growth and development and no history of orthodontic treatment from the ages of 3 years were chosen as subjects: Cephalometric X-ray were takem for 2 years and hard tissue analysis based on Burstone's COGS, which was divided into measurements of 6 parts (Cranial base, Maxillar and Mandible, Vertical measurements, Horizontal measurements, Basal bone relationchip, Dental measurements.) The relationship between craniofacial growth and body height & weight was studied. The following conclusions were obtained : 1. The maximum growth in the measurements of cranial base, N-Ar(FH) corresponded with the age the maximum increasein body height & weight in both boys and girls. 2. Gonual angle gradually decreased with in both boys and girls. 3. N-ANS(L) showed greater amount of growth than ANS-Me(L), and this had greater influence on facial profile. 4. N-A-Pogdegrees decreased with aging, and mandibular growth exceeded maxillary growth in amount and rate. 5. Length of Y-axis increased, but Y-axis to FH plane remained condtant. This show that mandible grows at a constant angulation to cranial base. 6. As permanert teeth erupt, interincisal angle deceased.
Aging ; Body Height ; Child* ; Female ; Growth and Development ; Humans ; Mandible ; Skull Base ; Tooth

Orthodontic patients are individuals that grow and develop; therefore selection of the proper time for orthodontic treatment is considered to be one of most difficult and yet difficult factor. Since the development of cephalometric X -ray, amount and pattern of craniofacial growth change with aging could be predicted and be came useful in the process of orthodontic treatment. The relationship between the mean values of cephalometric measurements and body height and weight was studied among the groupstboys and girls) of Korean children from the ages 6--years to 17-years. 409 boys and 437 girls with no abnormality in growth and development and no history of orthodontic treatment from the ages of 6 years to 17 years were chosen as subjects: Cephaloment X -ray were taken for 3 years and hard tissue analysis based on Burstone's COGS, which was devided into measurements of 6 parts(Cranial base, Maxillar and Mandible, Dental measurements). The relationship between craniofacial growth and height & weight was studied. The following conclusions were obtained: 1. The maximum growth in the measurements of cranial base, N-Ar(FH), N-Ba(FH) corresponded with the age with the maximum increase in body height & weight in both boys and girls. 2. Gonial angle gradually decreased with aging in both boys and girls. 3. N-ANS(L) showed greater amount of growth than ANS-Ne(L), and this had greater influence on facial profile. 4. N-A-Pogdegrees decreased with aging, and mandibular growth exceeded maxillary growth in amount and rate. 5. Length of Y-axis increased, but Y-axis to FH plane remained constant. This show that mandible grows at a constant angulation to cranial base. 6. As permanent teeth erupt, interincisal angle deceased.
Aging ; Body Height ; Child* ; Female ; Growth and Development* ; Humans ; Mandible ; Skull Base ; Tooth

In order to assess the physical growth pattern of Korean Youth, the authors measured the body height, chestgirth and sitting height of 40967 persons (24832 males and 16135 females) from primary schools, middle and high schools and colleges of metropolitan (urban) and rural areas, and calculated the mene, standard deviation, standard error and coefficient variance of the body weight chestgirth, sitting height and various pertinent index by body height to demonstrate the standard physical growth and development by body height of sex and age. The following conclusions were obtained. 1. Physical growth and development: Rapid growth of physical growth in terms of body height has been observed among males in the age 7-15 and among female 7-13. Growth in terms of body height turned out to be slower among students of higher age by both sexes. The age of cross over between to sexes is between 10 to 13 years where upon girls out grows boys. Maximum annual growth were upon girls out grows boys. Maximum annual growth were both of 6.16cm from 8 to 9 years old and 12 to 13 years old for boys and 7.2cm from 8 to 9 and 6.1cm from 9 to 10 for girls. This indicates that girls enter a rapidly growing stage 2 years earlier than boys. Meanwhile, prominent improvement in body height of national students over period of ten year was noticed. 2. The distribution status of body height by age: The distribution status of body height by age were as follows; 7 year of age: boys-30cm range of body height from 104.0cm to 133.9cm, girls-27cm from 104.0 to 130.9cm, 8 year of age: boys-30cm from 116.0 to 145.9cm, girls-33cm from 113.0 to 145.9cm, 9 year of age: boys-30cm from 116.0 to 145.9cm, girls-33cm from 113.0 to 145.9cm, 10 year of age: boys-39cm from 116.0 to 154.9cm, girls-39cm from 119.0 to 157.9cm, 11 year of age: boys-45cm from 119.0 to 163.9cm, girls-39cm from 122.0 to 160.9cm, 12 year of age: boys-45cm from 125.0 to 169.9cm, girls-42cm from 125.0 to 166.9cm, 13 year of age: boys-45cm from 128.0 to 172.9cm, girls-42cm from 128.0 to 169.9cm, 14 year of age: boys-48cm from 131.0 to 178.9cm, girls-36cm from 134.0 to 169.9cm, 15 year of age: boys-42cm from 137.0 to 181.9cm, girls-33cm from 137.0 to 169.9cm, 16 year of age: boys-39cm from 146.0 to 184.9cm, girls-30cm from 143.0 to 172.9cm, 17 year of age: boys-39cm from 146.0 to 184.9cm, girls-27cm from 143.0 to 169.9cm, 18 year of age: boys-36cm from 152.0 to 187.9cm, girls-27cm from 146.0 to 172.9cm, 19 year of age: boys-30cm from 155.0 to 184.9cm girls-24cm from 146.0 to 169.9cm, 20 year of age: boys-24cm from 158.0 to 181.9cm girls-18cm from 149.0 to 166.9cm, 3. Standard values of body weight, chest-girth and sitting height by body height of age were found all age groups from 7 to 20 years old and listed in tables from 3-a to 16-a. 4. Standard values of relative body weight, relative chestgirth and relative sitting height by body height of age were found all age groups from 7 to 20 years old and listed in tables from 3-b to 16-b. 5. Standard values of physical and nutritional indices (Rohrer index, Kaup index, Vervaeck index and Pelidisi index) by body height of age were found all age groups from 7 to 20 years old and listed in tables from 3-c to 16-c.
Adolescent* ; Body Height* ; Body Weight ; Child ; Female ; Growth and Development* ; Humans ; Male ; Nutrition Assessment ; Young Adult

It is well known fact that physical growth and development of children are influenced by many factors. The importance of socio-economic, geographic and cultural background cannot be over-emphasized in the evaluation of general pattern of physical growth and development of children. In this study the author measured and studied the body height and body weight of children living in the region of mine and industry located in Young-Wol Kun, Kang-Won Do, for the purpose of exploring out the influence of socio-geographic factors to act on physical growth and development of children. Total number of samples were 4,147 comprising 2,170 in male and 1,977 in female with ages ranging from 7 to 15. 1) The growth curves showed that young males grow slowly by 14 years of age, here-after rapidly and the young females grow slowly by 12 years of age, rapidly by 13 years of age and slowly thereafter. 2) The annual increment curves of body height and body weight showed that the most increment of female occurs by 13 years of age and that of mate, by 15 years of age. 3) The growth curves of the male and female crossed twice. It shows the difference of the pattern of growth between the both sexes. 4) The standards for the children in this region were presented. 5) The time of changes of stndard deviation curves of body height and body wegiht coincided nearly with that of annual increment. 6) Body weight and body height .of the children is larger than that of Korean children before World War II, but smaller than that of standards of recent Korean.
Body Height* ; Body Weight* ; Child* ; Female ; Gangwon-do ; Growth and Development ; Humans ; Male ; World War II

To evaluate the efficacy and safety of aromatase inhibitor letrozole in treatment of male adolescents with idiopathic short stature (ISS). Seventy five boys with height less than 2 standard deviation (SD) below the mean who had entered puberty were enrolled in our study from 2004 to 2017, in the Pediatric Department of the First Affiliated Hospital, Sun Yat-Sen University. Among 75 patients, 28 in letrozole group received letrozole and spironolactone, 30 in gonadotrophin releasing hormone analogue (GnRHa) group received GnRHa injection and 17 had no intervention. Height velocity (HV), increment of bone age/chronological age (ΔBA/ΔCA), the final adult height (FAH) were compared among groups and the safety of letrozole treatment was evaluated. HV maintained faster during letrozole treatment when compared with other groups. HV during GnRHa treatment showed slightly decline in the first 6 months, but decreased remarkably after 6 months, and was significantly lower than that in letrozole group ( < 0.05). The maturation of BA slowed down in both letrozole and GnRHa groups. But the ΔBA/ΔCA in letrozole group during the first and the second year of treatment were significantly higher (0.67±0.09, 0.50±0.15, respectively) when compared with GnRHa group (0.59±0.16, 0.44±0.13, respectively) ( =2.78 and 2.20, all < 0.05). FAH in letrozole group and GnRHa group were (170±4) cm and (170±6)cm, there was no significant differences between the two groups ( >0.05), and both were higher than that in no intervention group (162±4 cm, < 0.01). After 6 months of letrozole treatment, testicular volumes and serum testerone levels increased; 39.2% (11/28) boys had clinical manifestations of hyperandrogenemia, and 82.1% (23/28) boys had decreased serum high-density lipoprotein (HDL) levels. Serum levels of HDL and testerone returned normal and the hyperandrogenemia disappeared after the cessation of letrozole treatment. No significant changes in serum triglyceride, serum low-density lipoprotein (LDL), fating serum levels of insulin and glucose, HOMA-IR were observed. No abnormal liver function, myalgia, scoliosis or aggravations of scoliosis was found. Long term letrozole therapy during puberty in boys with ISS can delay bone maturation without significant decrease of linear growth, and thus can improve the final adult height. No severe adverse reactions were found.
Adolescent ; Body Height ; Bone Development ; Child ; Gonadotropin-Releasing Hormone ; Growth Disorders ; Humans ; Letrozole ; therapeutic use ; Male

As abnormal pubertal development, central precocious puberty (CPP) is manifested by the secondary sexual characteristics, skeletal maturation, and physical development in advance. It ultimately affects the adult height of children, even producing some psychological and behavioral problems such as fear and anxiety. Currently, gonadotropin releasing hormone analogue (GnRHa) is recognized as the best medicine worldwide for treating CPP in order to increase children's final adult height; however, it has some adverse effects on the growth and development of children. This paper reviews the effects of CPP and GnRHa on children's physical and sexual development, with the aim of increasing physicians awareness of this disease and the safety of medication.
Body Height ; Body Weight ; Bone Development ; Child ; Humans ; Puberty, Precocious ; physiopathology ; Reproduction ; Sexual Development

Adolescent ; Body Height ; Body Weight ; Child ; Female ; Growth and Development ; Humans ; Male ; Papilloma ; surgery ; Thyroid Neoplasms ; surgery ; Thyroidectomy ; adverse effects

OBJECTIVETo study serum insulin-like growth factor 1 (IGF-1) levels and their association with growth and development in infants aged 1-24 mouths.

METHODSA total of 525 healthy infants (125 preterm, 400 term) were enrolled. Serum IGF-1 levels were measured using ELISA 1.5, 4, 6, 8, 12, 18 and 24 months after birth. The body weight and body length were simultaneously measured.

RESULTSSerum IGF-1 levels were the lowest in preterm infants 1.5 months after birth (86+/-60 ng/mL). Thereafter, serum IGF-1 levels increased, and were significantly higher than those in term infants between 4 and 12 months after birth. Serum IGF-1 levels in term infants were the highest (116+/-52 ng/mL) 1.5 months after birth during their life of 12 months old. Thereafter, serum IGF-1 levels decreased and reached to a nadir (69+/-58 ng/mL) 8 months after birth. IGF-I levels were positively correlated with the weight and the height (SDS) in both preterm and term infants.

CONCLUSIONSSerum IGF-1 levels are closely associated with growth and development in infants.

Body Height ; Body Weight ; Child Development ; Female ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Insulin-Like Growth Factor I ; analysis ; Male