1.Apoptosis and Bcl-2 in Astrocytic Tumors.
Yeon Gyoe JANG ; Kum WHANG ; Soon Won HONG
Journal of Korean Neurosurgical Society 2000;29(4):486-490
No abstract available.
Apoptosis*
2.Bcl-2 Expression of the Primary Cutaneous Malignancies.
Sam Hyeong KIM ; Hoon KANG ; Sook Ja SON
Korean Journal of Dermatology 1997;35(5):847-853
No abstract available.
Apoptosis
3.Molecular mechanism and therapeutic targeting of necrosis, apoptosis, pyroptosis, and autophagy in cardiovascular disease.
Pan LI ; Xiao-Rong DONG ; Bei ZHANG ; Xin-Tong ZHANG ; Jing-Zhuo LIU ; De-Sheng MA ; Li MA
Chinese Medical Journal 2021;134(22):2647-2655
Cell death occurs in various tissues and organs in the body. It is a physiological or pathological process that has different effects. It is of great significance in maintaining the morphological function of cells and clearing abnormal cells. Pyroptosis, apoptosis, and necrosis are all modes of cell death that have been studied extensively by many experts and scholars, including studies on their effects on the liver, kidney, the heart, other organs, and even the whole body. The heart, as the most important organ of the body, should be a particular focus. This review summarizes the mechanisms underlying the various cell death modes and the relationship between the various mechanisms and heart diseases. The current research status for heart therapy is discussed from the perspective of pathogenesis.
Apoptosis
;
Autophagy
;
Cardiovascular Diseases
;
Humans
;
Necrosis
;
Pyroptosis
4.Attenuation of Oxidative Stress-Induced Cell Apoptosis and Pyroptosis in RSC96 Cells by Salvianolic Acid B.
Qian-Qian WANG ; Meng WANG ; Yan LI ; Yong-Hui LIU ; Lian-Qing SUN
Chinese journal of integrative medicine 2022;28(3):243-248
OBJECTIVE:
To determine whether salvianolic acid B (Sal B) exerts protective effects on diabetic peripheral neuropathy by attenuating apoptosis and pyroptosis.
METHODS:
RSC96 cells were primarily cultured with DMEM (5.6 mmol/L glucose), hyperglycemia (HG, 125 mmol/L glucose) and Sal B (0.1, 1, and 10 µ mol/L). Cells proliferation was measured by 3-(4, 5-cimethylthiazol-2-yl)-2, 5-dilphenyltetrazolium bromide assay. Reactive oxygen species (ROS) generation and apoptosis rate were detected by flow cytometry analysis. Western blot was performed to analyze the expressions of poly ADP-ribose polymerase (PARP), cleaved-caspase 3, cleaved-caspase 9, Bcl-2, Bax, NLRP3, ASC, and interleukin (IL)-1β.
RESULTS:
Treatment with HG at a concentration of 125 mmol/L attenuated cellular proliferation, while Sal B alleviated this injury (P<0.05). In addition, Sal B inhibited HG-induced ROS production and apoptosis rate (P<0.05). Furthermore, treatment with Sal B down-regulated HG-induced PARP, cleaved-caspase 3, cleaved-caspase 9, Bax, NLRP3, ASC, and IL-1β expression, but mitigated HG-mediated down-regulation of Bcl-2 expression (P<0.05).
CONCLUSION
Sal B may protect RSC96 cells against HG-induced cellular injury via the inhibition of apoptosis and pyroptosis activated by ROS.
Apoptosis
;
Benzofurans/pharmacology*
;
Oxidative Stress
;
Pyroptosis
;
Reactive Oxygen Species/metabolism*
5.The Role of Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN) in Lung Cancer.
Journal of Lung Cancer 2004;3(1):1-5
Lung cancer remains the primary cause of cancer-related death in the world, and the number of cases continues to increase. Like any other human cancer, the development of lung cancer is associated with the activation of oncogenes or inactivation of tumor suppressor genes. Phosphatase and tensin homolog, deleted on chromosome ten (PTEN), is a part of a complex signaling system that affects a variety of important cell functions. PTEN opposes the action of phosphatidylinositol 3-kinase (PI3-kinase) by dephosphorylating the signaling lipid phosphatidylinositol 3, 4, 5-triphosphate (PIP3). In addition, it displays weak tyrosine phosphatase activity, which may down modulate the signaling pathways involving focal adhesion kinase (FAK) or Shc. Functions for PTEN have been identified in the regulation of many normal cell processes, including growth, adhesion, migration, invasion and apoptosis. PTEN appears to play particularly important roles in regulating anoikis (apoptosis of cells after loss of contact with extracellular matrix) and cell migration. Many studies have suggested that the loss of PTEN expression occurs commonly in primary lung cancers and correlates with the histological type. Regulation of PTEN expression may provide a new preventive and therapeutic modality in primary lung cancer. However, there is, in our opinion, a need for further study of this gene
Anoikis
;
Apoptosis
;
Cell Movement
;
Focal Adhesion Protein-Tyrosine Kinases
;
Genes, Tumor Suppressor
;
Humans
;
Lung Neoplasms*
;
Lung*
;
Oncogenes
;
Phosphatidylinositol 3-Kinase
;
Phosphatidylinositols
;
Signal Transduction
;
Tyrosine
6.Apoptosis of Chondro cytes and Its Regulation in Pathogenesis of Osteoarthritis.
Hyon Jeong KIM ; Eui Cheol SHIN ; Nam Jin YOO ; Jeon Han PARK ; Sung Jae KIM ; Eung Shick KANG ; Jun Seop JAHNG
The Journal of the Korean Rheumatism Association 2001;8(2):104-117
No abstract available.
Apoptosis*
;
Osteoarthritis*
7.Apoptosis and Nuclear Shapes in Benign Prosta Hyperplasia and ProstateAdenocarcinoma: Comparsion and Relation.
Jang Wook SONG ; Nak Gyeu CHOI
Korean Journal of Urology 2000;41(2):317-322
No abstract available.
Apoptosis*
;
Hyperplasia*
8.Molecular Biological Approach to Apoptosis in the Developing Lung.
Journal of the Korean Pediatric Society 2001;44(3):246-251
No abstract available.
Apoptosis*
;
Lung*
9.Cellular Senes cence, Apoptosis and Carcinogenesis.
Journal of the Korean Geriatrics Society 2004;8(1):1-7
No abstract available.
Apoptosis*
;
Carcinogenesis*
10.Some discussion of apoptosis.
Journal of Medical Research 1998;7(3):34-35
Like every biological body, the cells under 4 phases: generation growth, development and end. There are 2 ways of the end of cell: necrosis death or apoptosis. The apoptosis related with some diseases that these disorders may be etiological mechanism of diseases. Today, the etiological mechenism of apoptosis has been discovered. The ways of inhibition or stimulation of this process in diseases of increased apoptosis are being studied.
Apoptosis
;
cells