Aims: Herbal and medicinal plants bioactive compounds of Jatropha curcas, Piper nigrum and P. betle have been shown to possess therapeutic properties. This study investigates the presence and characterization of phytochemical compounds as well as to evaluate the antimicrobial activities of the methanolic crude extract of the leaves and seeds of J. curcas, P. nigrum L. and P. betle. Methodology and results: The study on antibacterial and antifungal efficacy of the crude extracts of leaves and seeds were carried out using standard disc diffusion method. The crude extracts were found to exhibit an average response of antimicrobial activity with the inhibition zones ranged from 3% to 28% for antibacterial and from 21% to 79% for antifungal activity. Among all extracts, the leaf extract of P. betle showed a good antibacterial activity against Staphylococcus aureus and excellent antifungal properties against Aspergillus niger and A. flavus. The phytochemical screening analysis revealed the presence of saponin, tannins, glycosides, terpenoids, reducing sugar, flavonoid and anthraquinones. However, phlobatannins was not present. Total phenolic content (TPC) and total flavonoid content (TFC) were highly detected in the crude extract of P. betle and recorded as 13.33 mg of gallic acid equivalents, GAE (mg/ 100 mg sample) and 0.88 mg of RE (mg/100 mg sample), respectively. GC-MS analysis of the bioactive compounds reveals the presence of diethyl phthalate, 2-hexadecen-1-ol (Phytol), hexadecanoic acid, piperine, phenol and other minor compounds. Conclusion, significance and impact of study: The study suggested that P. betle has a potential as a source for antimicrobial agent from plants extracts. Nevertheless, further studies are needed to elucidate their precise mechanism of action.
Therapeutics

The randomized Controlled Trial is the standard design to prove the effectiveness of drugs or other forms of interventions. In this type of clinical research, individuals are randomly assigned (randomization) to either of the two or more groups, one with the intervention the other without the intervention being tested or another intervention. When done properly, it can provide the best evidence of effectiveness
Therapeutics

The objectives of national program of antituberculosis during 2001-2010 were to reduce to 50% of incidence and 50% of prevalence in order to reduced the morbidity rate, mortality rate of tuberculosis; early detect 75% of patients with the pulmonary tuberculosis with M. tuberculosis in the sputum; and reduce maximally the risks of drug resistance by successful treating 85% of patients under deployment of strategy of DOTS for 100% of tuberculosis patients
Tuberculosis ; therapeutics

Through application of bacterial biotherapeutic agents on clinical practice, we determined that Lactobacillus GG strains have high effect in treatment for acute diarrhea without blood, colitis caused by Clostridum difficile, diarrhea related to erythromycin, diarrhea with Rotavirus(+). Enterococcus faecium SF68 strain have also good effect in treatment for non-specific acute diarrhea. Steptococcus hemophilus have good effect in prophylaxis treatment. Saccharomyces boulardii was non-bacterial biotherapeutic agents. Only one type of enzyme has proved effectiveness in vivo and in vitro. Saccharomyces boulardii was considered by WHO as a useful agent in treatment for chronic colitis, recurrent colitis related to Clostridium difficile. Freeze-dried Saccharomyces boulardii has less side effects and easy to use
Diarrhea ; Therapeutics

Study on 70 acute pancreatitis patients (40 males, 30 females, aged 19 - 76) operated in Viet Duc Hospital from January 1999 to May 2002. Exclusive criteria: edema acute pancreatitis, necrotic pancreatitis without operation, necrotic pancreatitis was operated in basic settings. The results: the most of necrotic pancreatitis had no clear causes (74.28%). Mechanic causes included gallstone, worm (17.15%), acute pancreatitis after gall-pancreas area operation (1.43%). The disease was common in adults, mainly in 41-60 years old. In necrotic pancreatitis, pancreas could be necrotic very fast during the first 24 hours with shock, multi-organs failure, tympanites, vomit, peritoneum reaction and induction signs. The common symptoms were : increased blood amylase and urine amylase, leukocyte, blood urea, blood glucose; decreased blood calcium. CT scanner with a high accuracy rate (100%), was a gold criterion in diagnosis of necrotic pancreatitis. In operation, should minimized intervention. It is necessary to perform jejunotomy to decrease the expense due to intravenous feeding regularly.
Pancreatitis ; Therapeutics

There is about 30% of women experienced uterine fibroma and most of them needn’t treatment. For symptomatic women, various medical treatments were more and more extensive. Surgical treatments were indicated depending on many factors and individual patient. Besides traditional therapies (myomectomy, hysteroscopic myomectomy, uterine endoscopy, etc), there were more and more new techniques such as uterine artery embolization. This technique is relative new and minimal invasive of management, but it still needs further research
Leiomyoma ; Therapeutics

Studying the effectiveness of irradiation on bone-marrow, the numbers of leukocyte, erythrocyte, hemoglobin of mice (25 normal mice and 35 mice treated by gamma irradiation with the dose of 600 rad/(100rad/day) (60 Co) showed that: Gamma irradiation reduced total of leucocytes, the number of different leucocytic (lymphocyte, granulocyte, mono and natural killer cells), the ratio of reticulocyte, number of mature erythrocyte and hemoglobin: Total of leucocytes (3,14 ± 1,58 in comparison with 13,45 ± 4,6); monocytes (0,05 ± 0,03 in comparison with 0,26 ± 0,13), lymphocytes (1,66 ± 0,36 in comparison with 6,34 ± 2,84). After gamma irradiation, the number of reticulocyte was 55%, mature erythrocyte was 73% and hemoglobin was 82%
Therapeutics ; Mice

A prospective study was carried out to evaluate the severity of asthma by classification and to evaluate the GINA-based treatment. 102 asthma patients older than 1 year of age were classified in 4 steps of severity (GINA): step 1 (32 patients), step 2 (49 patients), step 3 (16 patients) and step 4 (5 patients). Most of asthma patients of steps 1 (31.4%) and of step 2 (48%) had slightly asthmatic symptoms and mildly affected lung function: PEF >80% (23.3%), moderately decreased PEF = 80% - 60% (57.5%). There were 1175 days of school-day or working-day loss. 32% of asthma patients had no specific treatment because of lack of knowledge; 48% of cases received an inappropriate treatment due to misdiagnosis and underestimation. 33.3% of patients used oral long acting β2 agonist (LABA) combined with inhaled corticosteroid (ICS); 25.4% of patients received inhaled LABA combined with ICS in our study; 66.6% of patients had lung function improved on 4th week of treatment
Asthma ; Therapeutics

We study 101 subjects including 44 men and 60 women who were defined that they got Atherosclerosis by vascular ultrasound. Upper 80% in the population are the middle aged and elderly subjects. The average of age: 61+/-9.32.The important measurable risk factor of atherosclerosis is disorders of lipid metabolism, the second is hypertension, the third is diabetes. The significant clinical event of atherosclerosis vascular disease is myocardial ischemia. The ratio of different cardiovascular and neurological events is relatively low, approximately 4-8%. We use simvastatin, fibrate, acid folic and omega 3 as therapeutic intervention on atherosclotic lesions.
Artherosclerosis ; therapeutics

Idiopathic scoliosis with Cobb angle between 20o and 40o is more common in female than in male, especially in adolescent girls (10 to 16 years). 18 patients with idiopathic scoliosis were treated at B¹ch Mai Hospital using TLSO brace jacket. The result showed that this brace jacket is convenient and does not impede the activities. It can correct about 30% in initiation. The level of correction decreases over time of bracing and after removing brace. After 2 years, there were 9 cases have improved by 50% in curve. The brace can prevent progress of scoliosis with Cobb angle of 40o.
Scoliosis ; Therapeutics