1.A Heuristic Algorithm to Find All Normalized Local Alignments Above Threshold.
Sangtae KIM ; Jeong Seop SIM ; Heejin PARK ; Kunsoo PARK ; Hyunseok PARK ; Jeong Sun SEO
Genomics & Informatics 2003;1(1):25-31
Local alignment is an important task in molecular biology to see if two sequences contain regions that are similar. The most popular approach to local alignment is the use of dynamic programming due to Smith and Waterman, but the alignment reported by the Smith-Waterman algorithm has some undesirable properties. The recent approach to fix these problems is to use the notion of normalized scores for local alignments by Arslan, Egecioglu and Pevzner. In this paper we consider the problem of finding all local alignments whose normalized scores are above a given threshold, and present a fast heuristic algorithm. Our algorithm is 180-330 times faster than Arslan et al.''s for sequences of length about 120 kbp and about 40-50 times faster for sequences of length about 30 kbp.
Molecular Biology
2.Molecular Genetic Assessment of Benign and Borderline Tumors as Precursor Lesions of Epithelial Ovarian Carcinoma.
Joo Hyun NAM ; Jong Hyuk KIM ; Joo Ryung HUR ; Gun Goo PARK ; Yong Man KIM ; Young Tak KIM ; Jung Eun MOK ; Soon Bum KANG
Korean Journal of Obstetrics and Gynecology 2000;43(12):2220-2230
No abstract available.
Molecular Biology*
3.Molecular analysis of childhood acute lekemia.
Hack Ki KIM ; Kyong Su LEE ; Sung Hoon CHO ; Du Bong LEE
Journal of the Korean Pediatric Society 1991;34(2):164-171
No abstract available.
Molecular Biology
4.Molecular Biology of Atherosclerosis.
Endocrinology and Metabolism 2010;25(3):166-170
No abstract available.
Atherosclerosis
;
Molecular Biology
5.Cell and Molecular Biology of Medicine and Cardiovascular System in Normal and Diseases.
Korean Circulation Journal 1992;22(2):207-218
No abstract available.
Cardiovascular System*
;
Molecular Biology*
6.Recent advances in molecular genetics of pediatric leukemias.
Journal of the Korean Pediatric Society 1993;36(5):605-614
No abstract available.
Leukemia*
;
Molecular Biology*
7.Molecular Genetics of Diabetes Mellitus.
Journal of Korean Society of Pediatric Endocrinology 2001;6(2):114-117
No abstract available.
Diabetes Mellitus*
;
Molecular Biology*
8.Molecular Genetics on the Hereditary Neurodegenerative Disorders caused by Trinucleotide Expansion.
Journal of the Korean Pediatric Society 1996;39(7):894-900
No abstract available.
Molecular Biology*
;
Neurodegenerative Diseases*
9.Molecular biology in diagnosis of communicable diseases
Journal of Medical and Pharmaceutical Information 2001;(11):14-18
This paper introduced some differences of molecular biological techniques from microbiological techniques and some advantages of molecular biological techniques. They comprised fast and early detection, safety, convenient, effective, inexpensive techniques, allowance for diagnosis of causative agents that not able to culture, facilitate for prognosis and monitoring of the treatment. The molecular biological techniques showed its important role more and more and combined with microbiological technique to improve the diagnosis, treatment and prognosis
Communicable Diseases
;
Molecular Biology
10.New achievements of molecular biology in oncology
Journal of Medical and Pharmaceutical Information 2000;(4):7-10
During transition years of 20th and 21st century, the molecular biology has had major progresses in the finding the nature of cancer's generation, early detection, prognosis and treatment of cancer. The molecular techniques were important breakthrough. The predominant achievement was to newly discover the role of telomere, telomerase and surviving in the cancer.
Molecular Biology
;
Medical Oncology
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