1.Hyperthyroidism in a pair of identical twins.
; G Hak MENG ; C Jin SENG
Singapore medical journal 1976;17(1):52-55
2.Studies of new sympathomimetic beta-receptor stimulating drugs in asthmatic patients. IV Acomparative trial of subcutaneous terbutaline (Bricanyl) and salbutamol (Ventolin).
J L Da COSTA ; B K GOH ; P C TEOH
Singapore medical journal 1976;17(1):7-9
Adolescent
;
Adult
;
Aged
;
Albuterol
;
pharmacology
;
therapeutic use
;
Asthma
;
drug therapy
;
Child
;
Female
;
Heart Rate
;
drug effects
;
Humans
;
Male
;
Middle Aged
;
Terbutaline
;
pharmacology
;
therapeutic use
3.Intestinal duplication.
Singapore medical journal 1976;17(1):61-62
Child
;
Humans
;
Infant
;
Intestines
;
abnormalities
;
surgery
;
Male
4.Pleural sarcoidosis.
Singapore medical journal 1975;16(3):224-226
Adult
;
Female
;
Humans
;
Pleural Diseases
;
pathology
;
Sarcoidosis
;
pathology
5.Clinical trial of orciprenaline in bradyarrhythmias.
L Chin HOCK ; C C TOH ; K Oon TEIK
Singapore medical journal 1975;16(2):100-105
6.Studies of new sympathomimetic beta-receptor stimulating drugs in asthmatic patients. III. A comparative trial of subcutaneous terbutaline and trimetoquinol.
J L Da COSTA ; B K GOH ; H Y LEE ; P C TEOH
Singapore medical journal 1975;16(2):143-146
Adolescent
;
Adult
;
Asthma
;
drug therapy
;
Czechoslovakia
;
History of Medicine
;
Humans
;
Injections, Subcutaneous
;
Isoquinolines
;
administration & dosage
;
Mental Disorders
;
drug therapy
;
Psychiatry
;
history
;
Terbutaline
;
administration & dosage
;
therapeutic use
;
Tranquilizing Agents
;
history
;
therapeutic use
;
Tretoquinol
;
administration & dosage
;
therapeutic use
8.The effect of a new steroid aerosol--beclomethasone dipropionate (Becotide) in chronic asthma.
Singapore medical journal 1974;15(2):106-109
Administration, Topical
;
Adolescent
;
Adult
;
Aerosols
;
Anti-Inflammatory Agents
;
administration & dosage
;
Asthma
;
drug therapy
;
Beclomethasone
;
administration & dosage
;
therapeutic use
;
Female
;
Glucocorticoids
;
Humans
;
Male
;
Middle Aged
;
Prednisolone
;
administration & dosage
;
therapeutic use
;
Time Factors
9.The use of midazolam and haloperidol in cancer patients at the end of life.
L K Radha KRISHNA ; V J POULOSE ; C GOH
Singapore medical journal 2012;53(1):62-66
INTRODUCTIONThis study aimed to describe the patterns of sedative use among terminally ill cancer patients who were referred to a hospital-based specialist palliative care service for symptom management. It also aimed to examine whether sedative use among terminally ill cancer patients during the last two days of life had any impact on their survival.
METHODSA retrospective review of case notes was carried out for patients with a diagnosis of terminal cancer, who died in a 95-bedded oncology ward between September 2006 and September 2007. Data was collected on patient characteristics, duration of palliative care, indications and doses of sedatives used at 48 hours and 24 hours before death.
RESULTSA total of 238 patients died while receiving specialist palliative care, 132 of whom (55.5%) were female. At 48 hours and 24 hours before death, 22.6% and 24.8% of patients, respectively, were on sedatives like midazolam, haloperidol or both. The median dose of midazolam was 5 mg/day while the haloperidol dose at 48 hours and 24 hours before death was 3 mg/day and 4 mg/day, respectively. The indications for midazolam were anxiety, breathlessness and stiffness, while those for haloperidol were confusion agitation and nausea. Survival analysis showed no significant difference in survival between patients who were on sedatives and those who were not. The p-value for log-rank test was 0.78.
CONCLUSIONThe results showed that the doses and overall frequency of sedative use in this patient population tended to be low and that usage of sedatives had no deleterious influence on survival.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analgesics, Opioid ; therapeutic use ; Female ; Haloperidol ; therapeutic use ; Humans ; Hypnotics and Sedatives ; therapeutic use ; Male ; Midazolam ; therapeutic use ; Middle Aged ; Neoplasms ; drug therapy ; mortality ; Palliative Care ; methods ; Retrospective Studies ; Terminal Care ; methods ; Terminally Ill ; Time Factors ; Treatment Outcome