On burn adult patients treated at the National Institute of Burn, the use of transfusion solutions on 40 patients showed that Ringer lactate and 5% glucose solution were the most common in all treatments for rehydratation and ion supplement. On 72 subjects antibiotics was used only monotherapy. The antibiotics were changed usually, in special cases there were 3 changing times
Anti-Bacterial Agents ; Therapeutics ; Burns

There are 4 principle of determination of ED50, the dose effective on 50% of experimental animals. Animals had been distributed into various analogue for diverse doses of studied substance. The evaluation will be carried according to the principle of "yes/no". For 1st example: To determine ED50 concerning the anti-fibrillation effect of venous infective propranolol on BaCl2 included heart fibrillation experimental model of rabbit.Result showed an efficacious dose of ED50 = 1,97mg/kg. For 2nd example: to determine ED50 concerning the hypoglycemic effect of glibenclamid on alloxan included hyperglycemic experimental model on white rat. Result showed on efficacious dose of ED50 = 6,02mg/kg
Diagnosis ; Pharmaceutical Preparations ; Animal Experimentation

The reality, some results and shortcomings of privatization process of state owned pharmacies were evaluated at period 1999-2003. The result: privatizating state owned pharmacies is relatively good, the amount of privatizated state owned pharmacies increase continously in past years. However, although there were 54,1% of provinces and cities implementing privatization but mainly that are enterprises belong to 2 regions of The Red river delta and South- East Viet Nam. This showed that the privatization process of regions isn’t equal. According to the plan, in 1998 there had been 7 units carrying out privatization but to the end of the 2000, there was only 1 first unit conversing successtly. That is the branch of Hai Phong 1 Health company changing into HaiPhong Health trade privatization company. Estimating to 12/2003, there were 8 center state owned pharmacies and 65 local state owned pharmacies privatized. They concentrate most in South VietNam
Pharmacies ; Pharmaceutical Preparations ; Epidemiology

The effect of buffer system, adjustment substance pH, pH of solution, antioxygen and antiseptic on the stability of eye drop solution with vitamin B5 was studied. The result: at pH 5,5, buffer system of acetat, of citrat and of phosphat strictly influence to the stability of eye drop solution containing vitamin B5. This solution also sustained with antioxygen dinatri edetat 0,02%, combining with natri metabisulfid 0,1% -0,3% don’t make increase the stability of product. The antiseptic of benzalkonium clorid and chlorobutanol don’t influence to the stability of this solution. But benzalkonium clorid is appropriate than chlorobutanol because of it don’t absorb through PE plastic, the antiseptic efficacy increase with the presence of dinatri edetat and this make increase the bioavailability of drug
Ophthalmic Solutions ; Pantothenic Acid ; Pharmaceutical Preparations

Experimental animal were 20 New Zealand rabbit with two sexes, weight of 2.30.3 kg. Experimental drug was Dia Long was prepared into smooth powder, put into gelule with content 0.25 (MD gelule) was made in Pharmaceutical Department of Military Traditional Medicine Institute. After 30 days receiving Dia Long with dose of 0.5 g/kg/day, the rabbits were still normal, rapid activities, good appetite, dry dung, smooth hair; didn’t experience hair falling out or dry hair. There wasn’t any rabbits experienced digestive disorder. There was no difference on hematological indices, biochemical indices of liver and kidney functions, serum electrolyte and clinical symptoms between control group and trial group after using drug. Histological damages of liver and kidney weren’t significant different between control group and case group
Pharmaceutical Preparations ; Medicine, Traditional ; Animal Experimentation

Forecast during 10 years from 2005 to 2014, the numbers of chemical drugs whose intellectual ownership will be expired are 83 substances with their turnover of over 100 billion USD. These are main substances that used for treating chronic diseases among non-communicable diseases - a disease pattern in the developed countries and industrializing countries, which Vietnam is one of them. To study about exploit coming to meet chemical drugs whose intellectual ownership will be expired, many generic manufactories have built research – development strategy in order to produce some specific generic groups, avoiding the simple “copy” of the formula and forms of available brand name products
Pharmaceutical Preparations ; Therapeutics ; Disease

Study on the extract of Morinda citrifolia (MC) fruit with the ratio of 5:1 (1g extract was prepared from 5g of dried MC fruit) in order to determine the effects of extract on radiation-induced immunosuppressive mice. The results showed that: oral administration of this extract with daily dose of 6 g/kg in 9 consecutive days (3 days before and 6 days during receiving gamma ray) has increased the relative weight of spleen and thymus, total leukocyte count, number of lymphocytes, natural killers and monocytes, rate of immune rosette forming cells, hemolytic halo, and the skin test with OA antigen, compared with the mice group that has been only received gamma ray without drug
Morinda ; Animal Experimentation ; Radiation

A HPLC method has been used to quantify plasma rifampicin and isoniazid and pyrazinamide simultaneously. Extraction of rifampicin in plasma samples was done as follows: mix 1ml of plasma containing rifampicin and 1.5 ml acetonitril on a vortex mixer for 1 minute prior to centrifugation at 3500 rpm for 30 minutes. The organic layer was filtered through 0.45m filter membrane and then 30l of this solution was injected into the HPLC system. The chromatographic conditions were as follows: in stationary phase: column: Apollo Alltech RP18 (250 x 4.6 mm; 5 m); in mobile phase: methanol - phosphate buffet solution containing 0.02M potassium dihydrogen phosphate adjusted to pH 4.5 by adding phosphoric acid (65: 35); Flow rate: 1.0 ml/min and UV detector: 254 nm
Chromatography, High Pressure Liquid ; lasma ; Pyrazinamide ; Isoniazid ; Rifampin

The way of counting average number and standard error or standard deviation by normal count method on all three lots showed the same results like as Microsoft - Excel. Application of Summary Statistics in Descriptive Statistics showed average value, standard error, standard deviation and many other results in which there are sample variance. If two variances of two samples are the same, T proof method is used. Like this, use of Microsoft Excel showed concrete numeric value of p
Mathematical Computing ; Computer

“Cỏ lưỡi rắn” (Hedyotis corymbosa (L.) and “lưỡi rắn hoa trắng” or “bạch hoa xà thiệt thảo” (Hedyotis diffusa Willd) are two different species. Both of them grow wildly in Viet nam. According to Viet nam traditional medicine, the species are used to make drug. They have antipyretic, detoxication effects, used in the treatment of inflammation and lesions induced by venomous bitten. Recently, the researchers determined active element in two species as ursolic acid, oleanolic acid and geniprosidic acid. These active ingredients have effect of tumor inhibition (in vivo and in vitro). In China, Hedyotis diffusa Willd was used to treat cancer
Plants, medicinal ; Medicine, Traditional