1.Radiation Therapy of a Chordoma of the Thoracic Vertebra: a Case Report and Review of Literatures.
Joo Young KIM ; Myung Sun CHOI
Journal of the Korean Society for Therapeutic Radiology 1988;6(2):295-300
Chordom is a malignant tumor arising from the primitive notochord involving the axial skeleton. It usually occurs at sacrococcygeal and basisphenoidal area but only rarely does at other vertebral areas, especially at the thoracic vertebrae. It has a slow growth rate and is locally aggressive with an extremely high rate of local recurrence. Either surgery or radiation alone often fails to cure the disease and the local failure is the main cause of treatment failure and death. Overall 5 year survival rate is less than 10%. Useful palliation or occasional cure can be obtained by the combination of surgery and radiotherapy. After incomplete resection, the tumor requires radiation dose of 7,000 cgy or more over 6-7 weeks for local control. Tumor regression is slow in response to irradiation and continuation of the regression for several months after completion of RT is not unusual. We report a case of chordoma of the thoracic vertebra, the site of extreme rarity, which showed good local control after partial resection and radiation therapy. He is well and alive without any evidence of recurrence after 13 months of treatment with near complete tumor regression.
Chordoma*
;
Notochord
;
Radiotherapy
;
Recurrence
;
Skeleton
;
Spine*
;
Survival Rate
;
Thoracic Vertebrae
;
Treatment Failure
2.Intracavitary Irradiation of Locally Advanced Recurrent Adenocarcinoma of Rectum Along the Fistula tract.
Kyeong Ae KIM ; Sung Kyu KIM ; Sei One SHIN ; Myung Se KIM ; Sun Kyuo SONG ; Min Chul SHIM ; Koing Bo KWUN
Journal of the Korean Society for Therapeutic Radiology 1988;6(2):289-294
Radiation therapy has been used as adjuvant therapy or primary treatment for inoperable, remnant or recurrent cancer. Many authors reported good palliation effect by external irradiation or interstitial therapy, but the report of intracavitary irradiation for recurrent, inoperable rectal cancer is very rare. We experienced a case of recurrent adenocarcinoma of rectum along fistula tract after laparotomy and postoperative radiotherapy who achieved very good palliation by intracavitary irradiation. Even though we have only good palliation without impressive survival improvement in this case, we hope that this technique may achieve good local control in other similar patients.
Adenocarcinoma*
;
Fistula*
;
Hope
;
Humans
;
Laparotomy
;
Radiotherapy
;
Rectal Neoplasms
;
Rectum*
3.Radical Radiotherapy with Lympectomy (Wide excisional biopsy) for Early Breast Cancer: A Case Report and Review of Literature.
Journal of the Korean Society for Therapeutic Radiology 1988;6(2):283-288
However, long-term results of retrospective studies suggest that, for the great majority of individuals, mastectomy or conservative surgery with radiation therapy were be equally effective. The results at 5 and 10 years from prospective randomized trials indicate that survival following primary radiation therapy for early breast cancer is equivalent to that following mastectomy. When competently performed, primary radiation therapy gives highly satisfactory cosmetic results and acceptably low rates of local tumor recurrence. A number of controversial issues remain concerning patient evaluation and selection and the optimal techniques of treatment, both surgical and radiotherapeutic. In addition, further work is needed to clearity the best way to integrate primary radiotherapy with adjuvant systemic treatment. And further follow-up these patients with primary radiation therapy for early breast cancer will be required for ultimate proof of the relative merits. A case which was conservative surgery and radical irradiation of early breast cancer with review of literatures will be done.
Breast Neoplasms*
;
Breast*
;
Follow-Up Studies
;
Humans
;
Mastectomy
;
Radiotherapy*
;
Recurrence
4.Ir-192 Brachytherapy Planning of Brain Tumor.
Tae Kin CHOI ; Jeong Ho PARK ; Ok Bae KIM ; Soo Ji SUH
Journal of the Korean Society for Therapeutic Radiology 1988;6(2):277-282
Although widely used in external beam treatment planning, computed tomography scans are infrequent in incranial tumors by implanting of Radioactive isotope. This incranial brachytherapy has only become possible by using CT scans and stereotaxic operation methods. The coincidence of single source and tumor axes in brachytherapy is very important to determine the therapeutic dosages. Eventhough using the CT scan, according to spatial location of tumor lying, the section of tumor will be seen enlargement, cause the tumor will be cut off with slight angle to its axes. Correct analysis of tumor size from source is required for rotated axes in analytical geometry.
Brachytherapy*
;
Brain Neoplasms*
;
Brain*
;
Deception
;
Tomography, X-Ray Computed
5.Stereotactic Radiotherapy by 6MV Linear Accelerator.
Yoon Kyeong OHO ; Mi Hee KIM ; Hak Jun GIL ; Sei Chul YOON ; Jae Moon LEE ; Kyu Ho CHOI ; Kyung Sub SHINN ; Yong Whee BAHK ; Moon Chan KIM ; Joon Ki KANG ; Jin Un SONG
Journal of the Korean Society for Therapeutic Radiology 1988;6(2):269-276
Eight patients with intracranial tumors or arteriovenous malformation (AVM)s which were less than 3 cm in diameter were treated by a technique of stereotactic radiotherapy during the 4 months period from July 1988 through October 1988 at the Division of Radiation Therapy, Kang-Nam St. Mary's Hospital, Catholic University Medical College. The patients were diagnosed as AVMs in 3 cases, acoustic neurinoma, craniopharyngioma (recurrent), hemangioblastoma, pineocytoma, and pituitary microadenoma in each case. There are several important factors in this procedure, such as localization system, portal, field size, radiation dose, and perioperative supportive care. It is suggested that stereotactic radiotherapy may be performed safely with a radiation dose of 12-30 gy. So this noninvasive procedure can be used to treat unresectable intracranial tumors or AVMs. Of these, clinical symptoms had been regressed in AVMs in 2 cases at 3 months and 2 months after Stereotactic radiotherapy, one of whom was confirmed slightly regressed on the follow-up angiogram. And also craniopharyngioma and pineocytoma was minimally regressed on 3 month follow-up CT.
Arteriovenous Malformations
;
Craniopharyngioma
;
Follow-Up Studies
;
Hemangioblastoma
;
Humans
;
Neuroma, Acoustic
;
Particle Accelerators*
;
Pinealoma
;
Portal System
;
Radiotherapy*
6.A Study on Dose Distribution around Fletcher-Suit Colpostat Containing 137Cs Source.
Journal of the Korean Society for Therapeutic Radiology 1988;6(2):263-268
This paper presents dose distributions in water around Fletcher-Suit colpostat containing 137Cs tube, and shielding effect of internal lead shield. Using ready packed film, author measured dose distribution in water around the colpostat containing cesium source. Nine sheets of films on one side of the colpostat are packed with acryl frames cut out so as to fill water, and irradiated in water by cesium source in the colpostat. Dose distributions on transverse plane and upper plane 0.5 cm from upper surface of the colpostat were measured. Shielding effect was greater in upper medial direction than in lower medial direction. And that was the greatest around 30degree from the axis of the colpostat on upper side and around 50degree on lower side. In the region 7 cm from the center of the colpostat, shielding efficiency was 0.23 to 0.35 on the lower 50degree and 0.26 to 0.42 on the upper 30degree, and decreased with increase of distance.
Axis, Cervical Vertebra
;
Cesium
;
Water
7.The Modified Method of Splenic Irradiation.
Su Mi CHUNG ; Hong Seok JANG ; Ihl Bohng CHOI ; Choon Yul KIM ; Yong Whee BAHK
Journal of the Korean Society for Therapeutic Radiology 1988;6(2):259-262
Splenic irradiation in chronic myelogenous leukemia is reserved for patients who have painful splenomegaly despite chemotherapy and/or inoperable splenomegaly because of huge size. The role of splenic irradiation is diminution of painful splenomegaly and indirect effect of splenic irradiation on unirradiated hematopoietic and lymphoreticular tissue such as reduction of leukocyte count and increase of hemoglobin level. We report on a useful clinical method for splenic irradiation in chronic myelogenous leukemia. We have used sonography as the tool of simulation. The portal size using modified method is smaller than the field size of conventional simulation, and so this method suggests that useful to irradiation of huge splenomegaly, effective shielding of critical organ and the downfall of complication during irradiation of spleen.
Drug Therapy
;
Humans
;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
;
Leukocyte Count
;
Spleen
;
Splenomegaly
8.The Radiation Effect on Peripheral Blood Cell.
Tae June LEE ; Hyoung Cheol KWON ; Jung Soo KIM ; Sun Kyun IM ; Ki Chul CHOI
Journal of the Korean Society for Therapeutic Radiology 1988;6(2):253-258
To evaluate radiation effect on the hematopoietic system, we analyzed 44 patients who were treated with conventionally fractionated radiation therapy (RT) at Chonbuk National University Hospital. According to the treatment sites, we classified them into three groups: group I as head and neck, group II as thorax, and group III as pelvis. White blood cell, lymphocyte, platelet and hemoglobin were checked before and during RT The results were as follow; 1. White blood cell (WBC) and lymphocyte count were declined from the first week of RT to the third week, and then slightly recovered after the third or fourth week. There was prominent decrease in lymphocyte counts than WBC. 2. Platelet counts were declined until the second week of the RT, showed slight recovery at fourth week in all groups. Hemoglobin values were slightly decreased in the first week and then recovered the level of pretreatment value, gradually. 3. Lymphocyte count were declined significantly on group III(p<0.01), WBC and platelet counts were decreased on group II but statistically not significant.
Blood Cells*
;
Blood Platelets
;
Head
;
Hematopoietic System
;
Humans
;
Jeollabuk-do
;
Leukocytes
;
Lymphocyte Count
;
Lymphocytes
;
Neck
;
Pelvis
;
Platelet Count
;
Radiation Effects*
;
Thorax
9.Total Body Irradiation in Leukemia: Preliminary Report.
Hong Seok JANG ; Su Mi CHUNG ; Ihl Bohng CHOI ; Choon Yul KIM ; Yong Whee BAHK ; Choon Choo KIM ; Dong Jip KIM ; Jae Soo LEE
Journal of the Korean Society for Therapeutic Radiology 1988;6(2):247-252
Total body irradiation has been applied to treat acute leukemia and chronic granulocytic leukemia. 20 patients with acute leukemia or chronic granulocytic leukemia were treated with total body irradiation using 6 MV linear accelerator before bone marrow transplantation at the Division of Therapeutic Radiology, department of Radiology, St. Mary's Hospital, catholic University Medical College from August 1987 to September 1988. Among 20 patients, 8 patients received 6 fractions of 200 cgy (total 1200 cgy), 10 patients received a single 850 cgy radiation, 1 patient received 4 fractions totaling 850 cgy (200, 200, 200, 250), and 1 patient received 1100 cgy in 2 fractions (850, 250). 17 patients received allogenic grafts, 2 patients received autologous grafts, and only one patients received one locus mismatched graft. 13 patients are still alive and 7 patients died. The complications induced by total body irradiation were nausea and vomiting, diarrhea, skin eruption, mucositis, and pneumonitis.
Bone Marrow Transplantation
;
Diarrhea
;
Humans
;
Leukemia*
;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
;
Mucositis
;
Nausea
;
Particle Accelerators
;
Pneumonia
;
Radiation Oncology
;
Skin
;
Transplants
;
Vomiting
;
Whole-Body Irradiation*
10.The Role of Radiotherapy in Management of Rectal Cancer.
John Kyu LOH ; Chang Geol LEE ; Jin Sil SEONG ; Soo Kon KIM ; Kyung Ran PARK ; Chang Ok SUH ; Gwi Eon KIM
Journal of the Korean Society for Therapeutic Radiology 1988;6(2):235-246
A total of 93 patients with rectal cancer treated with radiotherapy at department of Radiation Oncology, Yonsei University College of Medicine, Yonsei Cancer Center between January 1974 and December 1983 are retrospectively analysed. The patients are divided into three groups as follows: I. Postoperative radiotherapy, II. Pstoperative recurrent, III. Unresectable or Inoperable group. In postoperative radiotherapy group, overall 5 year survival rate is 34.8% and prognostic factors are presence of obstruction and degree of differentiation. In postoperative recurrent group, overall 5 year survival rate is 34.8% and prognostic factors are presence of obstruction and degree of differentiation. In postoperative recurrent group, overall 2 year survival rate is 7.4% with median survival of 13 months and prognostic factors are RT responsiveness and sex, and the local failure rate is 22.7%. In unresectable or inoperable group, overall 2 year survival rate is 19.8% with median survival of 12.6 months and prognostic factors are RT responsiveness and RT dose. The complications for RT are not significant and are acceptable in all patients.
Humans
;
Radiation Oncology
;
Radiotherapy*
;
Rectal Neoplasms*
;
Retrospective Studies
;
Survival Rate