[Objective]To review the antitumor progress of Raddeanin A in nearly 10 years. [Method] Col ecting the antitumor research literature about Raddeanin A for nearly 10 years, describing its antitumor research mechanism, such as inducting of cellapoptosis blocking the cellcycle, blocking STATs signaling pathways and inhibiting the tumor angiogenesis. [Result] Raddeanin A could induce the H460 cellapoptosis, block LoVo cellcycle and STATs signaling pathways of LoVo cells, and inhibit HepG-2 cellangiogenesis. [Conclusion] The antitumor mechanism of Raddeanin A could be inducting of cellapoptosis, blocking the cellcycle, blocking STATs signaling pathways and inhibiting the tumor angiogenesis.

[Objective] To discuss the nursing to the common complications in perioperational period of lung cancer treated with ultrasonic guidance transdermal radiofrequency ablation(RFA). [Method] 12 cases of peripheral lung cancer treated with ultrasonic guidance transdermal RFA, took active mental nursing, closely cooperated in operation, strictly observed the disease condition after operation, had good nursing of perioperational period, and were strengthened on observation of complications and prevention. [Result] 12 cases had smooth operation, part of them had pain at puncture spot, fever, little aerothorax and hydrops, with blood in sputum at cough, and were relieved timely with active observation and clinical nursing, without other severe complications, final y they were discharged from hospital upon recovery, without death in perioperational period. [Conclusion] The ultrasonic guidance RFA is a safe and effective method to treat peripheral lung cancer with little invasion; the nursing point is to closely observe disease condition before and after operation, and do wel general nursing.

[Objective] Explore the educational teaching in col eges and universities of our country question teaching method application and promotion. [Method] With historical retrospection and analysis of Chinese and western question teaching method on the beginning, development and evolution, analysis and synthesis, such as deductive and inductive methods, interpretation of China's current university question teaching method, not so good ap-plication of the objective and subjective factors, other factors, as wel as response measures. [Result] The current teaching in col eges and universities in our country question teaching method has not achieved good results or good application or popularization of China's higher education institutions, concepts and ways of teaching evaluation and teaching mechanism of objective factors, but also teacher and student's own subjective factors. [Conclusion] Our col-leges and universities must improve question teaching method in the status and role of education in the teaching of teachers in educational and teaching practice, to al ow students to learn how to find the issues, raise problems efforts, and properly regulate question teaching method class implementa-tion.

[Objective]It is to observe the clinical effect of bleeding in Zhongfu on pulmonary arterial hypertension induced by chronic cor pulmonale. [Methods]60 cases of patients with chronic cor pulmonale were randomly divided into two groups. Control group was given standardizing normal drugs , and the treatment group was added with bleeding in Zhongfu on the basis treatment above. Pulmonary artery pressure and index of blood rheology were compared between the two groups after 14 days. [Results]Compared with each other,the difference was significant( P<0.05). Indexes of pulmonary artery and blood rheology were al improved obviously after treatment in both groups, especial y in treatment group( P<0.05). [Conclusion]Combination with bleeding in Zhongfu can more effectively increase the clinical effect, low down pulmonary artery pressure and improve blood viscosity.

[Objective]To review the effect of treatment in chronic kidney disease and its preparation of Cordyceps sinensis. [Methods] By searching and reading the literature, to study the therapeutic effects of Cordyceps sinensis and its preparation on chronic kidney disease.[Results] Cordyceps and its prepa-ration could significantly decrease the proteinuria in patients with chronic kidney disease, serum creatinine level, significant improvement in renal fibrosis, and delay the progression of renal function. [Conclusion] Cordyceps and its preparation have obvious curative effect on chronic kidney disease.

[Objective]To investigate effect of PBL-Seminar teaching method in pharmacy.[Methods] Take 40 masters of pharmacy major from Zhejiang Chinese Medicine University, and 20 of them as test group(with PBL-Seminar teaching method) and others as control group(with traditional teaching method).With advanced pharmaceutics as an example, final y using the questionnaire to evaluate the teaching effect of the course. [Results] Compared with the control group, the test group shows increase significantly in cognitive depth of the major, learning initiative, awareness of the team, satisfaction of the teaching atmosphere. [Conclusion] The PBL-Seminar teaching method is innovative and effective, which effectively improves the students' initiatives and cognitive ability, and helps students to adapt to society.

[Objective]To investigate the mechanism of Qingre Yiqi Tongluo(QRYQTL) fang in treating the diabetic nephropathy. [Methods]60 Sprague-Dawleg rats were divided into normal control group(N), Diabetic nephropathy model group(M) (model rats were prepared by intraperitoneal injection with STZ after unilateral nephrectomy), then the model rats were assigned into model control group, QRYQTL fang treatment group(Q) and Irbesartan treatment group(I). After 12 weeks of the treatment, the contents of superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GSH-Px) and malondialdehyde (MDA) in renal tissue were examined by enzyme linked immunoassay(ELISA); the glomerular area(GA), mesangium area(MA),MA/GA, mean width of the podocyte foot processes(FPW) ,foot process fusion rate(FPFR) and average thickness of glomerular basement membrane(GBMT) were measured. [Results]Compared with N group, the contents of MDA in kidney homogenate and the GA,MA, FPW,FPFR,GBMT were markedly increased (P<0.01or P<0.05),the contents of SOD,CAT, GSH-Px and MA/GA were significantly decreased( P<0.01or P<0.05). QRYQTL fang reduced the level of MDA and decreased the GA, FPW, FPFR and GBMT(P<0.01or P<0.05). Compared with I group ,the QRYQTL fang was superior to Irbesartan in reducing the MDA, FPFR as wel as increasing the SOD,CAT(P<0.05).[ Conclusions]QRYQTL fang has a protective effect on the experimental diabec-tic nephropathy rats. The mechanism may be related to inhibiting oxidative stress, improving the body ’s antioxidant ability and al eviating the glomerular morphologic injury.

[Objective] To discuss the clinical effect of Levofloxacin in eye drop and oral taking on preventing infection for eyes traumas during perioperative period. [Method] Respectively select 126 cases of non-open eye trauma operation and 162 cases of open eye trauma operation, divide the non-open eye trauma patients into group A(Levofloxacin eye drop) 66 cases and group B(Levofloxacin injection in vein drop) 60 cases, compare both bacteria culture positive rates before administration and after operation;divide the open eye trauma patients into group C(Levofloxacin in eye drop and oral taking)80 cases and group D(Levofloxacin in vein drop) 82 cases, compare both positive rates of bacteria culture before and after the administration and operation.[Result] Comparing group A and group B with groups C and D, the positive rate before and after Levofloxacin administration, there ’s difference of statistical meaning, but without marked statistical meaning after operation. Side effects: the positive rate of bacteria culture was 56.25% before administration, and 10.13% after operation; for group D, they were 59.80% and 12.20% respectively, the difference had statistical meaning on Levofloxacin, but without difference of statistical meaning on positive rate. Purely using focal eye drop had no side effects on group A; the side effects of oral taking and focal administration on group C were much lower than groups B and D. [Conclusion] For eye trauma in perioperative period, the oral taking and eye drop of Levofloxacin have the same effects on infection prevention compared as vein drop, while the focal administration can reduce antibiotics usage and systemic administration, with little side effects, as wel as effectively prevent post-operation infection of eye trauma, worth clinical promotion and application.

[Objective] To discuss the effects of asphyxia on newborn baby ’s blood glucose, esp. the hypoglycemia. [Method] Choose 87 cases asphyxia newborn babies as observation group, compared with another 25 normal babies as control group, observe the relation between asphyxia degree and glucose concentration. [Result] In the observation group, the occurrence rates of hyperglycemia and hypoglycemia were much higher than control group, with dif-ference of statistical meaning. [Conclusion] The newborn babies of asphyxia are easy to have disordered glucose metabolism.

[Objective]Exploring from the specific case analysis of Chinese and western medicine treatment of primary amenorrhea with the clinical curative effect of infertility. [Method]In2013 January by Professor Xu Xiaofeng, doctor diagnosed primary amenorrhea with infertility and 1 patient of typicalcase, combined traditional Chinese medicine(TCM) and western medicine artificial menstrual cycle for 3 months, 3 months after the Chinese medicine Tiaozhou method combined with low dose of HMG with HCG inovulation induction treatment. [Result]After the treatment, the patients had pregnancy 70D, blood hormone and B Ultrasound examination were normal. [Conclusion]Combined treatment of TCM and western medicine is better than pure Chinese medicine or western medicine, suggesting that combination of TCM and western medicine is effective for the treatment of primary amenorrhea with infer-tility.