In the cover page of the paper, Conflict of interest and Author contributions should have been written as follows. Conflicts of interest: None. Author contributions: Yoo Mi Park and Hyojin Park planned this study. Yoo Mi Park and Young Ju Lee coducted the study. Young Ho Lee and Tae Il Kim contributed to revise and draft the manuscript. Yoo Mi Park wrote the paper.

The word "Delayed" in the legend of Figure 2 should have been written as "Controls."

No abstract available.
Depression* ; Gastrointestinal Diseases*

No abstract available.
Depression* ; Gastrointestinal Diseases*

No abstract available.
Esophagogastric Junction* ; Gastroesophageal Reflux* ; Humans

No abstract available.
Esophagogastric Junction* ; Gastroesophageal Reflux* ; Humans

No abstract available.
Chronic Pain*

No abstract available.
Asia* ; Dyspepsia* ; Endoscopy*

Chronic intestinal pseudoobstruction is often classified as idiopathic. The condition is associated with poor quality of life and high morbidity, and treatment options are often unsatisfactory. A case of chronic intestinal pseudoobstruction in a 66-year-old woman, presenting with back and abdominal pain, urinary retention and severe constipation is described. The patient lived in an area in which Lyme disease is endemic and had been bitten by ixodes ticks. Intrathecal synthesis of anti-borrelia IgM and IgG and lymphocytosis in the cerebrospinal fluid was found, consistent with chronic Lyme neuroborreliosis since symptoms had lasted for more than six months. The patient's gastrointestinal function recovered and the pain subsided significantly following treatment with antibiotics. Lyme neuroborreliosis (LNB) often results in palsy, but rarely affects the autonomic nervous system. Three patients have been described with intestinal pseudoobstruction due to acute LNB. However, this is the first described case of intestinal pseudoobstruction due to chronic Lyme neuroborreliosis. LNB must be suspected in patients with intestinal pseudoobstruction, in particular in patients who have been bitten by an ixodes tick and in patients living in an endemic area.
Abdominal Pain ; Aged ; Anti-Bacterial Agents ; Autonomic Nervous System ; Cerebrospinal Fluid ; Constipation ; Female ; Humans ; Immunoglobulin G ; Immunoglobulin M ; Intestinal Pseudo-Obstruction* ; Ixodes ; Lyme Disease ; Lyme Neuroborreliosis* ; Lymphocytosis ; Paralysis ; Quality of Life ; Ticks ; Urinary Retention

BACKGROUND/AIMS: Colon transit time (CTT) is a useful diagnostic tool in chronic constipation, but requires good patient compliance. We analyzed the correlation between the gas volume score (GVS) and CTT in patients with chronic constipation. METHODS: The study included 145 consecutive patients (65 men) with chronic constipation. The primary outcome was the correlation between the colon GVS and CTT. Secondary outcomes were the differences in colon GVS according to CTT and subtypes of chronic constipation. RESULTS: There were 81 patients with "CTT < 45 hours" and 64 patients with "CTT > or = 45 hours." In addition, 88 patients were classified as having functional constipation and 57 were classified as having constipation predominant irritable bowel syndrome (IBS-C). There was no significant correlation between CTT and colon GVS. However, the right colon GVS showed a positive correlation with right CTT (r = 0.255, P = 0.007). The median total colon GVS was significantly higher in patients with "CTT > or = 45 hours" than in those with "CTT < 45 hours" (5.65% vs 4.15%, P = 0.010). There were no significant differences in colon GVS between the functional constipation and IBS-C. CONCLUSIONS: We were unable to detect a correlation between GVS and CTT in patients with chronic constipation. However, total colon GVS may be a method of predicting slow transit in patients with chronic constipation.
Colon* ; Constipation* ; Gastrointestinal Transit ; Humans ; Irritable Bowel Syndrome ; Patient Compliance