1.A Case of Spinal Cord Compression Caused by Rhabdomyosarcoma of the Mediastinum Associated with Type I Neurofibromatosis(NF Type I).
Sei Yoon KIM ; Kum WHANG ; Soon Ki HONG ; Jhin Soo PYEN ; Chul HU ; Hun Joo KIM ; Young Pyo HAN ; Myoung Sup LEE ; Chong Kook LEE ; Mee Yon CHO
Journal of Korean Neurosurgical Society 2001;30(5):642-646
A 12-years-old female admitted to the hospital with the complaint of pain on the right upper chest area which persisted about 1 month prior to admission. Cafe-au-lait spots of various size laying on a whole body and freckling on the axilla were found on physical examination. A huge mass was found on the plain chest X-ray and on chest MRI. The mass encroached thoracic spine, posterior rib, back muscles, and then into the neural canal and compressed thoracic spinal cord. On the 5th day of hospitalization, the patient complained tingling on the both legs and 2 days later, monoparesis on the right leg. Open thoracotomy and decompressive laminectomy was done to remove mass. Pathologic reports confirmed rhabdomyosarcoma, embryonal type.
Axilla
;
Back Muscles
;
Cafe-au-Lait Spots
;
Female
;
Hospitalization
;
Humans
;
Laminectomy
;
Leg
;
Magnetic Resonance Imaging
;
Mediastinum*
;
Neural Tube
;
Paresis
;
Physical Examination
;
Rhabdomyosarcoma*
;
Rhabdomyosarcoma, Embryonal
;
Ribs
;
Spinal Cord Compression*
;
Spinal Cord*
;
Spine
;
Thoracotomy
;
Thorax
2.Ocular Complications after Injection of Intra-arterial Carboplatin in Gliomas.
Joo Han KIM ; Jang Bo LEE ; Yong Gu CHUNG ; Jung Yul PARK ; Hun Kap LEE ; Jung Keun SUH
Journal of Korean Neurosurgical Society 2001;30(5):638-641
Carboplatin intra-arterial chemotherapy(IAC) has an advantage of increased uptake during the first passage of the drugs through tumor capillaries. Although not common, this type of therapy is known to cause neurological complications, myelosuppression, and ototoxicity. However, the incidence of ocular toxicity is reported to be rare. Eleven of our patients with glioma(Grade II Astrocytoma: 3, Grade III Astrocytoma: 1, Grade IV Astrocytoma: 5, Gliofibroma: 1, Oligodendroglioma: 1) underwent IAC regimen with carboplatin(300mg/m2) which were administrated after blood-brain barrier disruption. Of there, 3 patients had ocular complications after supra-ophthalmic IAC injection of carboplatin but fully recovered following steroid therapy. Although our results from IAC seem to be favorable for these patients, we suggest that its complications, such as ocular toxicity, need to be carefully considered prior to treatment.
Astrocytoma
;
Blood-Brain Barrier
;
Capillaries
;
Carboplatin*
;
Glioblastoma
;
Glioma*
;
Humans
;
Incidence
;
Oligodendroglioma
3.Syringo-Pleural Shunt for Failed Syringosubarachnoid Shunt in Posttraumatic Syringomyelia.
Chang Woo LEE ; Yong Seog KIM ; Jong Sun LEE ; Moon Sun PARK ; Ho Gyun HA ; Joo Seung KIM
Journal of Korean Neurosurgical Society 2001;30(5):633-637
The authors report a case of syringo-pleural shunt for recurrent distal obstruction of syringosubarachnoid shunt in a 23-year-old woman. She complained of tingling sensation and dysesthesia on the left upper extremity. Neuroradiologic imaging studies revealed syringomyelia in the left lateral side of the cord from medulla to 7th thoracic cord level. We identified intraoperatively high internal pressure of the syrinx cavity due to distal shunt tube obstruction. Syringo-pleural shunt was performed and cavity size was markedly decreased at later follow up MRI. In conclusion, the posttraumatic syrinx, especially in cases with previous syringosubarachnoid shunt or diffuse subarachnoid scarring, can be successfully managed with syringo-pleural shunt.
Cicatrix
;
Female
;
Follow-Up Studies
;
Humans
;
Magnetic Resonance Imaging
;
Paresthesia
;
Sensation
;
Syringomyelia*
;
Upper Extremity
;
Young Adult
4.Epithelioid Hemangioendothelioma of the Spinal Cord.
Ki Tai KIM ; You Sam WON ; Seung Min LEE ; Jae Young YANG ; Chun Sik CHOI ; Mun Bae JU ; Joo Seob KEUM
Journal of Korean Neurosurgical Society 2001;30(5):627-632
Hemangioendotheliomas are vascular neoplasms characterized by histologic appearance that are intermediate between hemangiomas and angiosarcomas first described by Weiss and Enzinger in 1982. They are classified into at least 3 subgroups, including epithelioid hemangioendothelioma, spindle cell hemangioendothelioma, and malignant endovascular angioendothelioma, and have been reported principally in soft tissues of the extremities, lung, liver, and bone. The cases involving the central nervous system reported are very rare. We report an intraspinal epithelioid hemangioendothelioma occurring in a 52-year-old man. To our knowledge, it is first case of spinal hemangioendothelioma in Korea.
Central Nervous System
;
Extremities
;
Hemangioendothelioma
;
Hemangioendothelioma, Epithelioid*
;
Hemangioma
;
Hemangiosarcoma
;
Humans
;
Korea
;
Liver
;
Lung
;
Middle Aged
;
Spinal Cord*
;
Vascular Neoplasms
5.Acute Disseminated Encephalomyelitis(ADEM) Presenting as Multiple Cystic Lesions.
Dae Won KIM ; Tae Young KIM ; Jong Moon KIM ; Ki Jung YUN
Journal of Korean Neurosurgical Society 2001;30(5):622-626
Acute disseminated encephalomyelitis(ADEM) is an uncommon immune-mediated inflammatory demyelinating disorder that typically affects the white matter of the central nervous system. Radiologic findings of acute disseminated encephalomyelitis are not pathognomomic. The differential diagnosis is always difficult. Occasionally, the clinical features, radiological and histopathological findings of patients with acute disseminated encephalomyelitis mimic the brain tumor or other space occupying lesions. The authors report a 6-year-old girl who presented with right hemiparesis two days after nausea and vomiting. Brain MRI of the patient revealed non-enhanced multiple cystic lesions in subcortical white matter of both cerebral hemisphere with prominent edema. One of the cystic lesions was resected to differentiate with metastatic tumor or inflammatory disease such as abscess and confirmed as the acute disseminated encephalomyelitis via various immunohistochemical stains. Pertinent literature is reviewed with discussion on this uncommon ADEM associated with multiple cystic lesions.
Abscess
;
Brain
;
Brain Neoplasms
;
Central Nervous System
;
Cerebrum
;
Child
;
Coloring Agents
;
Demyelinating Diseases
;
Diagnosis, Differential
;
Edema
;
Encephalomyelitis, Acute Disseminated
;
Female
;
Humans
;
Magnetic Resonance Imaging
;
Nausea
;
Paresis
;
Vomiting
6.Endocrinological Results of the Transsphenoidal Microsurgery for Cushing's Disease.
Joon Soo KIM ; Chang Jin KIM ; Sang Soo HA ; Jung Hoon KIM ; Jung Gyo LEE ; Byung Duk KWUN ; Sung Kwan HONG ; Ki Up LEE ; Bong Jae LEE ; Yong Jae KIM ; Choong Kon CHOI ; Ho Gyu LEE
Journal of Korean Neurosurgical Society 2001;30(5):611-621
OBJECTIVE: We analyzed the clinical and endocrinological results of the transsphenoidal microsurgery for ACTH secreting pituitary adenomas. MATERIALS AND METHODS: From October 1995 to August 2000, 18 patients underwent transsphenoidal microsurgery for Cushing's disease. We analyzed the surgical results of 17 patients, one patient who was previously operated from other hospital was excluded. Age of the patients were 18 to 61 years old(mean 37.7), male to female ratio was 1: 3.3, and follow-up period was 3 to 50 months(mean 20.3). The selection of candidates for transsphenoidal exploration was based on endocrinologic criteria. Magnetic resonance imaging was the preferred radiologic test. Selective inferior petrosal sinus sampling of adrenocorticotropic hormone futher refined the diagnosis when endocrinologic and radiologic procedures were not definitive. RESULTS: Results of the preoperative endocrinological test were: level of serum ACTH 29.4 to 225ng/dL(mean 93.88ng/dL); serum cortisol 11.9 to 47.5ng/dL(mean 27.49ng/dL); 24-hour urine free cortisol 235 to 1019ng/day(mean 571.0ng/day). Inferior petrosal sinus sampling for ACTH was performed in 11 patients and all were confirmed by Cushing's disease and we could predict the laterality of the tumor in 9 of 11 patients. We performed transsphenoidal selective adenomectomy in 5 patients, adenomectomy and subtotal hypophysectomy in 2 patients, adenomectomy and partial hypophysectomy in 9 patients, and in the remaining one patient, hemihypophysectomy followed by total hypophysectomy due to remission failure. Fifteen of 17 patients(88.2%) showed endocrinological remission. Glucocorticoid replacement therapy was performed in all the patients who showed remission for 1 to 24 months(mean 5.9 months), and 6 patients received steroid over 6 months. CONCLUSION: We conclude that the direct demonstration of a tumor in the pituitary gland by MRI is the most important and definitive diagnostic tool and the location of a mass should be confirmed with increased level of ACTH by the inferior petrosal sinus sampling. Transsphenoidal microsurgery is effective treatment modality for Cushing's disease and the immediate postoperative evaluation of the surgical resection of the tumor is very important. The patients should show hypocortisolism, decreased, subnormal serum ACTH and cortisol levels and 24-hours urine free cortisol. We performed 18 transsphenoidal microsurgery for Cushing's disease in 17 patients and 15 patients(88.2%) showed endocrinological remission.
ACTH-Secreting Pituitary Adenoma
;
Adrenocorticotropic Hormone
;
Diagnosis
;
Female
;
Follow-Up Studies
;
Humans
;
Hydrocortisone
;
Hypophysectomy
;
Magnetic Resonance Imaging
;
Male
;
Microsurgery*
;
Petrosal Sinus Sampling
;
Pituitary Gland
7.Efficacy of Calcium Sulfate Pellets as Bone Graft Substitute in Lumbar Posterolateral Fusion.
Seung Ku LEE ; Choong Hyun KIM ; Jin Hwan CHEONG ; Koang Hum BAK ; Jae Min KIM ; Suck Jun OH
Journal of Korean Neurosurgical Society 2001;30(5):605-610
OBJECTIVE: The authors investigated the efficacy of the calcium sulfate(OsteoSet(r) pellets) as an autograft extender when used to perform posterolateral lumbar fusions. PATIENTS AND METHODS: Twenty patients who underwent lumbar posterolateral arthrodesis for various spinal diseases between October 1999 and March 2000 were evaluated. Arthrodesis was performed by transpedicular screw fixation and bone grafting with a mixture of autograft + calcium sulfate in a 1:1 ratio. At time intervals of 1, 2, 3, and 6 months, postoperative radiographs were obtained to review the resorption of calcium sulfate and the evidence of fusion. A modified Lenke scale was used to assess the status of the fusion. RESULTS: At 2 months after operation, the average modified Lenke scale score for the OsteoSet(r) pellets group was 3.8. However at 6 months after operation, the average modified Lenke scale score for the OsteoSet(r) pellets group was 1.8. Resorption of calcium sulfate pellets was revealed in all cases at 6 months after surgery. CONCLUSION: It is presumed that a combination of calcium sulfate and autograft can play a role as an effective autograft extender in the posterolateral spinal fusion.
Arthrodesis
;
Autografts
;
Bone Transplantation
;
Calcium Sulfate*
;
Calcium*
;
Humans
;
Spinal Diseases
;
Spinal Fusion
;
Transplants*
8.Results of Microsurgical Anterolateral Tunnel Approach for Cervical Disc Herniation.
Woo Young JANG ; Keun Soo KIM ; Jung Chung LEE ; Chul Jin KIM ; Ha Young CHOI ; Xiu Nan XUAN ; Dong Han HAN
Journal of Korean Neurosurgical Society 2001;30(5):600-604
OBJECTIVE: The authors report the microsurgical anterolateral tunnel approach for the treatment of the cervical disc diseases and its postoperative surgical results. METHODS: All surgical procedures followed the method of classical microsurgical anterior discectomy. Small tunnel(7-8mm) was made on the disc space reaching to the posterior longitudinal ligament. The disc materials and bony spurs were removed through this tunnel. Thirty-one patients of cervical disc herniation(24 cases with pure disc herniation, 7 cases with combined cervical spondylosis) were evaluated on the symptoms, conformation in plain X-ray, C-T, and MRI. The follow up time was over 2 years . RESULTS: Postoperatively the result(following the out come scale) was excellent and good in Twenty-nine patients. One with fair result showed remnant disc particle and spur and another one is combined with cord contusion. One patient with lesion in C 3-4 space and two cervicothoracic junction showed excellent result. Two patients with osteoporosis also showed good results. Cervical spine curvature and disc space height were not changed on the plain X-ray and MRI in all patients. Twenty-nine patients were discharged within 3 days after surgery without any postoperative complications. CONCLUSIONS: The microsurgical anterolateral tunnel approach could be indicated for the treatment of patients with cervical disc diseases and with difficulty in achieving interbody fusion(the higher cervical level and cervicothoracic junction, osteoporosis etc.).
Contusions
;
Diskectomy
;
Follow-Up Studies
;
Humans
;
Longitudinal Ligaments
;
Magnetic Resonance Imaging
;
Osteoporosis
;
Postoperative Complications
;
Spine
9.Prognostic Factors in the Treatment of Anterior Communicating Artery Aneurysms.
Juno PARK ; Taek Hyun KWON ; Youn Kwan PARK ; Hung Seob CHUNG ; Hoon Kap LEE ; Jung Keun SUH
Journal of Korean Neurosurgical Society 2001;30(5):592-599
OBJECTIVE: The anterior communicating artery(ACoA) is known to be the most frequent location of intracranial aneurysms, but the complex arterial anatomy of the ACoA region makes this aneurysm among the most difficult one to treat. In the treatment of ACoA aneurysms, the direction of aneurysmal fundus is known to be very important in the surgical tactics. All ACoA aneurysms in our series were classified according to its direction, and analyzed the clinical features in order to investigate the prognostic factors influencing upon the surgical outcome. METHODS: The authors reviewed 236 cases of ruptured ACoA aneurysms that were operated from 1990 to 1997, were classified according to Pia's classification. RESULTS: The incidence rate of the ACoA aneurysm was 35.1%(236/672). Ventral group was more common than dorsal group, especially in ventro-caudal projection subgroup(36.0%). Poor preoperative clinical grade(Hunt-Hess grade IV and V) patients were more common in dorsal group(13.1%) than ventral group(2.6%). Rebleeding and intracerebral hematoma were more commonly seen in ventral group. However, vasospasm, hydrocephalus, hyponatremia, and intraventricular hemorrhage were observed more frequently in dorsal group. Worse outcome was more common in dorsal group than ventral group, especially in dorso-caudal projection subgroup. Also, poor outcome was identified in patients with intracerebral hematoma, intraventricular hemorrhage, hyponatremia, and hypertension, although statistically insignificant. In cases with the A1 dominancy, there was no difference in surgical outcome between the right and left side approach. The higher the aneurysmal neck from the planum sphenoidale, the worse outcome via pterional approach. CONCLUSION: It seems that the preoperative clinical grade, aneurysmal direction, and the height of aneurysmal neck, especially in the pterional approach, would be the major prognostic factors, and that intracerebral hematoma, intraventricular hemorrhage, hyponatremia, hydrocephalus and the intraoperative aneurysmal rupture would be the minor prognostic factors.
Aneurysm
;
Classification
;
Hematoma
;
Hemorrhage
;
Humans
;
Hydrocephalus
;
Hypertension
;
Hyponatremia
;
Incidence
;
Intracranial Aneurysm*
;
Neck
;
Rupture
;
Temazepam
10.Endoscopy Assisted Transsphenoidal Surgery for Pituitary Tumors.
Young Sang AHN ; Young Il CHUN ; Jae Sung AHN ; Sang Ryong JEON ; Jeong Hoon KIM ; Young Shin RA ; Sung Woo ROH ; Chang Jin KIM ; Yang KWON ; Seung Chul RHIM ; Jung Kyo LEE ; Byung Duk KWUN
Journal of Korean Neurosurgical Society 2001;30(5):586-591
OBJECTIVE: Transseptal or sublabial transsphenoidal surgery has been standard teatment for pituitary tumors for decades. However, as an alternative to this surgery endonasal endoscopic technique has been reported with encouraging results. We have started endoscopy-assisted transsphednoidal surgery from May 1998. In this paper we analyzed the methods, outcome, advantage and disadvantage of this surgical approach for the purpose of planning optimal treatment of pituitary tumors. METHODS: This study consisits of 13 cases of pituitary tumors who were treated by endoscopy-assisted transsphenoidal surgery using one nostril from May 1998 to July 1999. Mean follow up period was 12.9 months. RESULTS: There was no septal or sublabial incision and little surgical damage to nasal structure. With this technique, rapid surgical approach and short hospital day were possible, being 3-6 days in patients without CSF leakage. Using various angled endoscope, good surgical view was obtained. Initially it was difficult to use various instruments in narrow nasal cavity, but became feasible after several procedures. Among 13 cases, total removal was possible in 11 cases. One of two cases in whom tumor was incompletely removed underwent gamma-knife radiosurgery and second underwent reoperation through subfrontal approach. There were 6 cases of hormone secreting tumors and hormonal remission was achived in all of these cases. Postoperative complications were CSF leakage(6 cases), diabetes insipidus(2 cases) and panhypopituitarysm(1 case). Lumbar drainage was done in all cases of CSF leakage. CONCLUSION: The advantage of endoscopy-assisted transsphenoidal surgery are rapid surgical approach, low postoperative morbidity, short hospital day and good surgical view. The disadvantage of this appoach are difficulty in manupulating various instruments in narrow nostril and difficulty in distance perception but these problems can be overcome by practice and using stereoscopic endoscope.
Distance Perception
;
Drainage
;
Endoscopes
;
Endoscopy*
;
Follow-Up Studies
;
Humans
;
Nasal Cavity
;
Pituitary Neoplasms*
;
Postoperative Complications
;
Radiosurgery
;
Reoperation