ObjectiveTo explore the therapeutic method of acute obstructive suppurative cholangitis (AOSC). Methods47 patients with acute obstructive suppurative cholangitis were collected and the clinical feature,therapy methods and therapy effects were analyzed. ResultsAll the patients were accepted operation.28 patients were cured.The cured rate was 59.6%.16 patients got improvement and the rate was 34.0%.The total effective rate was 93.6%.The therapeutic effect was better.There were 3 patients died because serious septic shock and multiple systemic organ failure. ConclusionThe timely and effective operations to remove the obstruction of biliary tract,controls the infection,corrected the shock and prevent and treat complication were the key of reduce the death rate of patients.

Objective To evaluate the effect of the Danhong injection combined with irbesartan in treatment ofearly diabetic nephropathy. Methods 64 patients with early diabetic nephropathy were randomly divided into two groups and the control group 32 cases,two groups were given control of blood sugar and ensure water and electrolyte balance,support therapy,in which 32 cases were also observed red Danhong injection,Ecuador irbesartan treatment,2weeks before evaluation. Results The total effective rate in treatment group was higher than the control group( x2 =6.38 ,P ＜0. 05) ,after 12 weeks of treatment,two groups of urinary protein decreased significantly compared with before treatment, including observation of urine protein was ( 0. 6± 0. 1 ) g/24h, the control group was ( 0. 7 ± 0. 3 ) g/24h,and decreased urine protein level of the observation group was better than the control group( t = 2. 74,P ＜ 0. 05 ). And in the course of treatment, side effects and serious adverse events were not found. Conclusion Danhong injection combined irbesartar, could improve the clinical symptoms, reduce microalbuminuria in treatment of early diabetic nephropathy is worthy of wider application.

Objective To evaluate the short-term efficacy and toxicity of perfusion in pleural cavity with bruceolic oil emulsion and cisplatin for malignant pleural effusion. Methods 64 patients with malignant pleural effusion received thoracentesis catheterization in pleural cavity and were devided into 2 groups:the treatment group and the control group. The treatment group(32 cases) were perfused with bruceolic oil emulsion 60 ～ 80ml every time and DDP 60mg/m2. The control group(32 cases) were perfused with DDP 60mg/m2 only,they used it once a week. All patients completed therapy 4 weeks. Results The response rate of treatment group was 81.3% and 56.3% for the control group(x2 =4.65,P＜0.05).There was no difference in toxicity between two groups(P＞0. 05). Conclusion The efficacy of perfusion with bruceolic oil emulsion and cisplatin in pleural cavity was of promise. It could improve the life quality of the patients. The toxicity is weak,it was worth of clinical application.

Objective To explore the clinical meanings of serum CA19-9 levd in hepatocirrhosis patients. Methods 61 hepatitis B and hepatocirrhosis patients were as treatment group, and 35 normal were as control group. The content of serum CA19-9 was measured by dectrochemistry lighting and the liver function was determined too. According to Child-Pugh liver function integral method,the treatment group was divided into 27 cases of A grade,20 cases of B grade and 14 cases of C grade. Results The serum CA19-9 level in hepatocirrhosis patients was higher than that of normal group significantly(P< 0. 005 ). The serum CA19-9 level decreaed obviously through the treat- ment,thereinto A and B grade fell evidendy in the Child-Pugh liver function integral method( P < 0. 005). C grade was not significantly different(P<0.05 ). The serum CA19-9 levd was positivdy associated with TBiL, ALT and AST of liver function integral method. Conclusion The serum CA19-9 levd of hepatocirrhosis patients is improved in different degrees. And it can be a prognostic target and used to estimate the degree of damage of liver function of hepatocirrhosis patients.

Objective To compare the effect of hip artificial replacement and DHS internal fixation for the treatment of intertrochanteric fracture, and investigate the difference of the two method. Methods Eighty-six pa- tients with intertrochanterie fracture patients were treated with hip arthroplasty, and dynamic hip screw. The pa- tients were followed up for 6 months, and compared the operation rime, blood loss, postoperative complications, sur- vival rate, postoperative hip function score and lose situation. Results There was no significant difference in opera- tion time,blood loss,postoperative complications,in local symptoms hip varus deformation occured in the DHS inter- hal fixation because lag screw cut-our and the collapse of the medial cortex, hip and thigh pain oecured in artificial re- placement,hip function score dropped 9.5 % in DHS and 9.2% in artificial replacement. Conclusion For elderly patients, eomminuted fracture and osteoporosis, and other types of unstable intertrochanteric fracture patients, the primary purpose of surgery is to provide to patients more activities of the early conditions,so hip arthroplasty can be used to the treatment of intertrochanteric fracture,as a reasonable replacement surgery.

Objective To summarize the clinical effects of retrograde intramedullary nail in treating distal femora| fracture. Methods Retrospectively analysed 52 cases of intereondyiar and supracondylar fracture of femur treated with retrograde intrameduUary nail. Results All cases were followed up for 6 to 24 months. All fracture were union except 2 reoperations cases had delay union. Conclusion Retrograde intrameduUary nail has supreme biological stability and allowed early exercise. It also can shorten operation time, reduce damage of periosteum and reduce delay union rate.

Objective To investigate the application of get-well treatments in the suffers after thorax opera- tion over 70 years old. Methods 68 suffers after thorax operation over 70 years old were divided to two groups. Comparison group( n = 32 ) is actualized general nurse. Experiment group( n = 36) is actualized lung function exercise before operation, and get-well treatments after operation, such as psychologic get-well, deep breath, abdominal breath, effective cough and sputuming, applying apparatus training breath; exercise limbs and body, atomization in- breath, and so on. Results The suffers in experiment group who have lung atrophy,lung infection, liquid in the tho- rax,the time in the hospital and the time holding thorax pipe are less than the suffers in comparison group. Conclu- sion Lung function exercise before operation and effective get-well treatments after operation have significant ef- fects on old suffers.

Objective To explore the significance, indicatinos and complications of emergency tracheotomy for patients with severe craniocerbral trauma. Methods The clinical data of 42 patients with severe craniocerbral trauma were retrospectively analyzed. Results Of them, 20 were basically cured (48%), 12 had improvement (29%) ,3 were released from the hospital(7 % ), 1 survived(2 % ) in a vegetative state,and 6 died(14%). Conclu- sion Emergent tracheotomy should be performed on patients with severe craniocerbral trauma to resolve respiratory tract obstruction, improve air current, prevent cerebral anoxia, prevent and treat pulmonary infection, increase the therapeutic efficacy.

Objective To investigate the possible role of abnormal signal transduction in smooth muscle cell in the pathogenesis of diabetic gastroparesis. Methods Healthy male SD rats were randomly divided into 2 groups: normal,model group,diabetes was induced by Ⅳ of alloxan,50mg/kg. Gastric emptying was measured by method of nutritious semisolid paste. The level of cAMP in gastric smooth muscle cell was measured by radioimmunoassay. Gsαand GiαmRNA positive cells were quantitatively measured by in situ hybridization and computer image analysis system respectively. Results ( 1 ) Gastric emptying rate of the normal was significantly higher than that of model group (P < 0.05 ) ; (2)the level of cAMP of the normal was significantly lower than that of model group( P < 0.05 ) ; (3)the expression of GsαmRNA in the model group was significantly higher than that of the normal groups( P < 0.05 ) ; (4) there was no marked difference in the expression of GiαmRNA between 2 groups( P > 0.05). Conclusion Altered expression of GSαmRNA may play a key role in the pathogenesis of diabetic gastroparesis.

Objective To study the evolution and significance of cellular immune function in the children with nephrotic syndrome. Methods The level of peripheral blood T lymphocyte, netural killer in the children with nephrotic syndrome( n = 45) and normal controls group ( n = 30 ) were detected by flow cytometry. Results The percentage of CD3+ cells, CD4+ cells, CD(+16 + 56)+ cells and the ratio of CD4+/CD8+ were significantly lower at nephrotic syndrome active stage than thee in nephrotic syndrome catabasis stage and normal controls group( P < 0.05 ), the percentage of CD3+ cells were significantly lower at nephrotic syndrome catabasis stage than that in normal control group( P < 0.05 ). Conclusion The invasion of nephrotic syndrome was related to cellular immune function.