To investigate the mechanism of Xiefei Dingchuan injection (XFDCI,泻肺定喘注射液) in treating pulmonary hypertension by means of measuring the activity of Ca2＋Mg2＋ ATPase and Na＋K＋ATPase of red blood cell(RBC) membrane.Methods:The pulmonary hypertension models induced by monocrotaline in 18 rats were established then treated with XFDCI.Using cardiac catheter and chromatometry respectively the pulmonary artery pressure (PAP) and the activities of Ca2＋Mg2＋ATPase and Na＋K＋ATPase of RBC membrane were measured.Results:The activities of Ca2＋Mg2＋ATPase and Na＋K＋ATPase of RBC membrane in XFDCI group were obviously higher than those in pulmonary hypertension group.Conclusions:XFDCI is able to reduce the pulmonary hypertension and its mechanisms may be related to increasing the activities of Ca2＋Mg2＋ATPase and Na＋K＋ATPase of RBC membrane.

Objective:To investigate the clinically curative effects of Liyuan Pure Lysothrombusase(LYPL，力源精纯溶栓酶) on unstable angina pectoris (UAP) and to observe its safety.Methods:One hundred and twenty cases with UAP were selected and in accordance with the proportion of one to one randomly divided into treated and control group.Based on conventional therapy the LYPL infused intravenously was added in treated group.The conditions of symptomatic convalescence,the changes in electrocardiography (ECG),and the parameters of blood rheology were observed for two groups.Results:The curative effects on symptoms and ECG were 93.33％ and 88.33％ respectively in treated group but in control group they were 70.00％ and 68.33％ respectively.The difference in comparison between two groups was significant (all P<0.01).In treated group the parameters of blood rheology were obviously improved meanwhile in control group they were not.Conclusions:LYPL possesses the actions on improving blood rheology.Its curative effects on UAP are marked and it is safe and easy to use.

Objective:To investigate the curative effects and mechanism of Shuxuetong injection (疏血通注射液) on treating coronary heart disease(CHD).Methods:The treated group (n=20) based on conventional therapy was treated with Shuxuetong injection infused intravenously,meanwhile the control group treated with conventional therapy only.Before and after therapy the changes in concentrations of plasma endothelin(ET),thromboxin B2(TXB2),6ketoprostaglandin F1α(6ketoPGF1α) and blood rheology between two groups were compared.Results:After therapy the clinical symptoms were convalescent,the ET and TXB2 reduced,the 6ketoPGF1α increased,and the parameters of blood rheology improved.Conclusions:Shuxuetong injection is able to dilate vessels,increase blood flow volume,anticoagulate,and improve blood rheology so that it is effective drug to treat CHD.

Objective:To observe the clinically curative effects of Qingwen Baidu drink(清瘟败毒饮) on epidemic hemorrhagic fever (EHF).Methods:One hundred and eighty cases with EHF who were admitted to hospital within 5 days after onset were randomly divided into two groups.The control group (n=60) was treated with Ribavirin infused intravenously and liquid therapy,and treating complications simultaneously,meanwhile the treated group (n=120) based on the same therapy as control group treated with Qingwen Baidu drink number Ⅰ,Ⅱ or Ⅲtaken orally two times a day according to different course.Results:In treated group all the days of fever,polyuria,recovering platelet to normal,and transforming proteinuria to negative were significantly shorter than those in control group (both P<0.01),otherwise the overphase rates of oliguria and hypotension shock were higher than those in control group too (all P<0.01).The occurance rate of complications in treated group was lower than that in control group(P<0.05).Conclusions:The curative effects adding Qingwen Baidu drink on EHF are significant and worth spreading.

Objective:To observe the curative effects of Ciwujia injection (刺五加注射液) on traumatic subarachnoid hemorrhage (tSAH).Methods:Patients with tSAH were divided into different groups to treat.One group were treated with conventional therapy,and another group were treated with conventional therapy and Ciwujia injection infused intravenously.The curative effects were observed.Results:In treatment group of Ciwujia injection the cured rate was increased,the disability rate reduced,the life quality improved,the therapeutic course shortened,and the cost depressed.Conclusions:Ciwujia injection possesses obviously clinically curative effects and practical significances in treating tSAH.

Objective:To explore the relationship between Feng syndrome(风证) and plasma endothelin(ET)in initial condition of acutely ischemic stroke.Methods:Using the table of syndrome quantitative diagnosis which formulated according to experiences of apoplectic experts to grade the fraction of syndrome which appears in initial condition of 151 cases with acute cerebral infarction，at the same time the level of plasma ET was determined by radioimmunoassay(RIA),and then according to the fraction of syndrome patients were divided into two groups,one is Feng syndrome group,the other is nonFeng syndrome group，the levels of plasma ET in this two groups and with healthy subject were compared.Results:It showed that the level of plasma ET in Feng group was significantly higher than that in nonFeng group（P<0.001）；and the same result between the patients and the healthy subjects（all P<0.001） were obtained.Conclusions:The results demonstrate that there is a correlated relationship between Feng syndrome and plasma ET,and the level of plasma ET can be regarded as a microcosmic indices to separate Feng syndrome from nonFeng syndrome.

Objective:To observe the curative effects of puerarin injection(葛根素注射液) on variant angina pectoris(VAP) and its influences on endothelial functions.Methods:Fortyeight cases with VAP were randomly divided into treated and control group.The treated group was treated with puerarin injection 300500 mg infused intravenously once a day，meanwhile the control group treated with conventional therapy.The therapeutic course was 1014 days for both groups.Before and after using drugs the changes in endothelin(ET) and nitric oxide (NO) were observed in two groups.Results:In both groups after therapy the clinically symptomatic convalescences and changes in electrocardiography (ECG) compared with before therapy had significant differences,but in comparison between two groups the differences had not statistical significant.Otherwise regarding to the ET and NO the differences were significant between treated group and control group.Conclusions:Puerarin injection not only possesses obviously curative effects on symptomatic convalescence and ECG changes but also is able to improve the endothelial functions.

ObjectiveTo observe the clinical curative effect of nasal jejunal nutrition support in stroke patients with gastric retention.Methods Forty-two patients with cerebral apoplexy combined with gastric retention admitted to Dingxing County Hospital in Hebei province from March 2012 to November 2015 and treated with enteral nutrition support were enrolled, and they were divided into observation group and control group according to the random number table method, 21 cases in each group. Under the guidance, routine treatment were given, the head of bed was raised to 30°- 45°, and gastrointestinal decompression was carried out in the two groups. In the observation group, a nasal jejunal tube was inserted and enteral nutrition was given, while in the control group, parenteral nutrition was firstly applied until the recovery of gastrointestinal function, then nasogastric enteral nutrition was carried out. Compared between the two groups, on the day of admission before treatment and 2 weeks after treatment, blood glucose levels, plasma total protein levels, albumin were detected; the triceps skinfold thickness (TSF), upper arm circumference (MAC), upper arm muscle circumference (AMC), etc were measured in the two groups to show the difference in nutritional status. Adverse reactions of diarrhea, stress ulcer, gastrointestinal tract infection, reverse flow, high blood sugar and central venous infection and complications in the two groups were observed.Results The levels of blood glucose, albumin, total protein content were not significantly different between the two groups before treatment (allP > 0.05). Blood glucose levels in the two groups after treatment were lower than those on admission, and the decrease in the observation group was more significant (mmol/L: 6.45±2.15 vs. 7.68±2.68,P < 0.05); the levels of albumin and total protein in the control group after treatment were lower than those on admission, while the observation group had no such significant changes, and the levels of the control group were significantly lower than those of the observation group [albumin (g/L): 30.78±4.12 vs. 38.20±4.67, total protein (g/L): 63.91±4.32 vs. 67.11±3.12, P < 0.05]. After treatment for 2 weeks, the nutritional indexes of TSF, MAC, AMC in the two groups were slightly lower than those on admission, but the degrees of descent in observation group were not as significant as those in the control group [TSF (mm): 11.91±1.29 vs. 10.13±1.37, MAC (cm): 24.19±3.12 vs. 23.74±2.08, AMC (cm): 22.64±2.05 vs. 21.73±2.15, allP < 0.05]. The incidences of adverse reactions and complications in the observation group were significantly lower than those in the control group [diarrhea: 9.5% vs. 38.1%, stress ulcer: 4.8% vs. 33.3%, regurgitation:4.8% vs. 28.6%, hyperglycemia: 9.5% vs. 38.5%,P < 0.05]; In the control group, the incidence of central venous infection was 4.8%.Conclusions Gastric jejunal nutrition support in patients with cerebral apoplexy combined with gastric retention can prevent occurrence of malnutrition, reduce the incidences of adverse reactions and complications and promote the rehabilitation of patients.

ObjectiveTo explore the effect of patients with acute cerebral infarction (ACI) at different ages receiving intravenous injection of alteplase for thrombolysis on their prognosis.Methods Ninety-eight ACI patients admitted to Jinghai Hospital of Tianjin from January 2014 to December 2015 were conducted in this study, and they were divided into elderly group (over 75 years old) and younger age group (under 50 years old). The patients in two groups of were given intravenous thrombolytic therapy with alteplase (0.9 mg/kg), 10% of the dose was intravenously injected, and continuously the remaining dose was pumped into the vein for 1 hour. Before the thrombolysis and 1 day and 21 days after thrombolysis, the score of United States National Institutes of Health Stroke Scale (NIHSS) was used to evaluate neurological deficits, the incidence of bleeding adverse event and mortality were recorded.Results Compared to the before thrombolysis, the NIHSS scores after thrombolysis on the 1st day and 21st day were significantly decreased in the two groups (the younger age group 1 day: 6±4 vs. 10±5, 21 days 2±2 vs. 10±5, the elderly group 1 day: 7±5 vs. 10±7, 21 days: 6±4 vs. 10±7, allP < 0.05), and NIHSS score in the younger age group was significantly lower than that in the elderly group on the 21st day after thrombolysis (2±2 vs. 6±4,P < 0.05). After thrombolysis, the incidence of minor mucocutaneous bleeding in elderly group was obviously higher than that in younger age group, the difference being statistically significant [7.69% (4/52) vs. 2.17% (1/46),P < 0.05]; the elderly group had higher symptomatic intracerebral hemorrhage and death events than those in younger age group [1 (1.92%) vs. 0].Conclusion Different ages of patients with ACI can benefit from intravenous thrombolysis with alteplase, showing the younger the age of the patients, the better the benefit they can get and have relatively better prognosis.

ObjectiveTo observe the clinical efficacy of acupuncture for treatment of children with acute brain injury.Methods A prospective study was conducted. Sixty-one children with brain injury admitted to Guiyang Maternal and Child Health Hospital from January 2014 to April 2016were enrolled, and they were randomly divided into acupuncture group (31 cases), and conventional treatment control group (30 cases). All cases with operation indications received craniotomy and tracheal intubation, and after operation symptomatic treatment, ventilator assistance, etc. were given to the patients; in acupuncture group,acupuncture was applied after vital signs were stable, the main acupoints being neiguan, renzhong, sanyinjiao, siguan, yongquan, baihui, shixuan, etc. once needle retention time at points 30 minutes, 5 times a week, 10 times for a therapeutic course, the therapeutic course being 2 weeks. The therapeutic effects were evaluated according to the modified Glasgow coma scale (GCS) and the CT image scoring method. Results After treatment, the coma (GCS) and brain injury (CT score) situations in the acupuncture group were more significantly improved than those in control group (P < 0.05). After treatment, compared with the control group, the number of cases with clear mental state was increased (22 cases vs. 15 cases), the number of cases with shallow coma and elevated GCS score was increased (27 cases vs. 19 cases), of cases with improvement in brain morphology and reduced CT score was also increased (22 cases vs. 13 cases) in the acupuncture group (bothP < 0.05); and of dead cases without any therapeutic effect was less (2 cases vs. 4 cases) in acupuncture group, but their differences were not statistically significant (P > 0.05). The time of treatment in acupuncture group were significantly shorten compared with that of the control group (weeks: 2.7±0.7 vs. 3.7±0.4,P < 0.01). The total effective rate of acupuncture group was significantly higher than that of control group [90.3% (28/31) vs. 70.0% (21/30),P < 0.05].Conclusion Acupuncture has a significant effect for treatment of children with acute brain injury.