OBJECTIVE: To study the how's for pharmacists at inpatient pharmacy to provide pharmaceutical care for improved safe and effective use of drugs. METHODS: Pharmacists at inpatient pharmacy can provide pharmaceutical care as per specific clinical needs, and start from such details as preparing the booklet of commonly-used chemotherapy drugs, offering face-to-face advises on drug use for diabetics, and helping nurses to manage the medicine cabinets. RESULTS & CONCLUSION: Pharmacists at inpatient pharmacy should provide the right pharmaceutical care that can meet actual clinical needs.

OBJECTIVE: To establish a method of GC-Second Order Temperature Programming for determining the residual quantities of 4 organic solvents-methanol, acetonitrile, pyridine and dimethylformamide-in Methylprednisolone Sodium Succinate. METHODS: The separation was performed on DB-5 capillary column, with flame ion monitor as detector, and with high pure nitrogen, air and hydrogen as carrier gas. The column temperature was subjected to GC-Second Order Temperature Programming, with the temperature of sample injector at 200℃ and that of detector at 220℃. The make-up gas was high pure nitrogen. The split ratio was 10∶1. The sample size was 2?L and the butanone was taken as the internal standard. RESULTS: The four kinds of solvents were linear within their respective concentration range. The average recoveries of methanol, acetonitrile, pyridine and dimethylformamide were 99.4%, 99.2%, 99.3% and 99.0%, respectively, with RSD at 1.8%, 1.8%, 2.0% and 1.7%, respectively. CONCLUSION: The method was proved to be sensitive, accurate and simple.

OBJECTIVE: To develop a method for determination of the content of Dexamethasone acetate in Compound tretinoin ointment by RP-HPLC. METHODS: The separation was performed on C18 column with methanol: water (70∶30) as a mobile phase, wavelength of UV detector at 240nm. RESULTS: The linear range of Dexamethasone acetate was within 0.028 3～0.849 0?g(r=0.999 9). The average recovery of Dexamethasone acetate was 101.13%, with RSD at 1.28%. CONCLUSION: The method is simple, rapid and capable of producing good separation results. It can be applied to the quality control of Compound tretinoin ointment.

OBJECTIVE: To prepare Indomethacin-hydroxypropy-cyclodextrin inclusion complex ointments and establish its assay method. METHODS: The preparation was prepared with O/W type emulsion ointment as base material, and the content of Indomethacin in which was determined by UV spectrophotometry. RESULTS: The calibration curve of Indomethacin was linear in the range of 16.76～41.91?g?mL-1(r=0.999 6),and its average recovery was 99.53%(RSD=1.50%). CONCLUSION: The ointments were convenient in preparation technique, and simple and accurate in determination.

OBJECTIVE:To upgrade and achieve the management targets of drug storehouse. METHODS: Based on the tasks for drug storehouse, the application of THIS System in the management of drug storehouse was studied. RESULTS: The application of THIS System in management of drug storehouse helps transform traditional manners and improve work efficiency and quality. CONCLUSION:The flexible application of current technique and improvement of information system is an important approach to achieve work efficiency and quality as well as the management targets of drug storehouse.

OBJECTIVE: To conduct a quantitative evaluation on pharmaceutical research performance in our department. METHODS: Our department's annual research performance during 2001～2005 was scored by integrated weighting method. RESULTS: The research performance in our department over the five years achieved overall high scoring, especially in 2003 and 2004. CONCLUSION: Integrated weighting method can be used to evaluate pharmaceutical research performance.

OBJECTIVE: To study the enhancing effect of N-trimethyl chitosan with degree of quaternization of 60% (TMC60) on the estradiol gel in vitro. METHODS: TMC60 was synthesized and the degree of quaternization was determined by 1H-NMR. Three different kinds of estradiol gels, 2% TMC60 group, 2% azone group and blank control group, were studied respectively. The cumulative penetration Q and steady penetration rate J in vitro were used as the indices. The cumulative penetration was calculated. RESULTS: The degree of quaternization of TMC60 was 67.2%. Significant difference was found the value Q and J of TMC60 group when compared to blank control group(P0.05). CONCLUSION: 2% TMC60 is a penetration enhancer with similar enhancing effect as 2% Azone, which deserves further research.

OBJECTIVE: To develop a method of HPLC/MS/MS to determine phenacetin and paracetamol in rat liver microsomal incubation system. METHODS: Samples were separated on XTerra MS C18 column, different ratios of methanol- 0.1% formic acid were used as the gradient eluent, and the flow rate was 0.2mL?min-1. The electrospray ion-quadrupole mass spectrometry and multiple reaction monitor were adopted to detect the concentration of phenacetin and paracetamol. RESULTS: The calibration curves were linear in the ranges of 45～9 000ng?mL-1(r=0.999 8)and 15.2～1 520ng?mL-1(r=0.999 6) for phenacetin and paracetamol respectively; The lowest limits of assay were 9ng?mL-1 and 10ng?mL-1.The average recoveries at three concentrations of phenacetin were (96.2?2.3)%～(98.3?2.4)% and those of paracetamol were (99.6?2.1)%～(100.2?2.6)%; RSD of the intra-day and inter-day were less than 5%. CONCLUSION: The method is rapid, sensitive and suitable for determination of phenacetin and paracetamol in rat liver microsomal incubation system.

OBJECTIVE: To establish a RP-HPLC method for the determination of 5-fluorouracil(5-Fu)in magnetic micropheres (MMS), and to evaluate the target ability of 5-Fu magnetic microspheres in mice. METHODS: 5-Fu-MMS was digested with 0.5% pepsin, and then free 5-Fu was extracted from tissue with ethyl acetate, and detected by a validated RP-HPLC method. RESULTS: The calibration curve was linear over the range of 0.1～25mg?L-1 and the limit of quantization was 0.1mg?L-1. The tissue distribution of 5-Fu-MMS in the liver was significantly increased as compared to control(P

OBJECTIVE: To discuss the current status of pharmaceutical advertising market in China for improved regulatory control. METHODS:The positive contribution of pharmaceutical advertising to the economy and society was analyzed, and the reasons behind fraudulent drug ads that occurred frequently in recent years were examined. RESULTS&CONCLUSION: Pharmaceutical advertising forms the mainstay of China's advertising market, which is needed for marketing purposes. To regulate fraudulent drug ads, related regulatory control should be strengthened in combination with enhancing consumers' knowledge.