In terms of drugs' concerted application regulation,this article studies usage of drugs in different prescriptions in ZHANG Zhong-jing's Treatise on Cold Pathogenic Diseases and Synopsis of Golden Chamber,and summarizes various drugs' concerted application as follows: First,composite of mutual promotion between two drugs in similar properties;Second,composite of several drugs in same flavour;Third,composite of fusion of flavors and drugs;Fourth,composite of drugs available in same nature;Fifth,composite of drugs in cold and hot nature;Sixth,composite of tonic and laxative;Seventh,composite of the use of mutual assistance between drugs in different properties;Last,composite of change of drugs according to different syndromes.Also,the article,integrating with Zhong-jing's prescriptions,discusses the different concerted apllication above in detail.

Objective: To observe the effect of Tongluo Jiunao oral solution on learning and memory and the expression of AChE in hippocampus of AD rats induced by ?-amyloid1-40.Methods: 140 SD rats were divided into blank control group(normal group),pseudo-operation control group,negtive control group(model group),positive control group and experiment group(48、24、12mg?kg-1?d-1)at random.The model of AD were established by injecting ?-amyloid1-40 into bilateral hippocampus.After 4 weeks,Morris Water Maze was used to determine the ability of learning and memory.Immunohistochemical method and image analysis techniques were used to determine the expression of AChE in Hippocampus.Results: Compared with normal group,in place navigation test,the mean escape latencies of the model group increased obviously,and in spatial probe test,the frequency of passing through the platform of the model group decreased obviously(P

0.05).Compared with Radix Astragali and blood-activating drugs,Buyang Huanwu Decoction have notable effect(P

Ascending,descending,entering and exiting of qi movement is the basic form of the human life activity.Its dysfunction is a basic reason for diseases.The clinical value of starting with regulate the qi movement,summarize the causes,pathogenesis and symptoms of various kinds of diseases and determine the treatment based on syndrome are significant.

Epilepsia is a frequent neural system disease of pediatrics,treatment based on syndrome differentiation in Traditional Chinese Medicine is more efficacious to certain extent.Because symptoms are multiplex and patients often go to see a doctor in resting stage,it is difficult to differentiate sydromes.During years of clinical practice,professor Ma Rong used the knowledge of electroencephalogram,attack type of Western Medicine,symptoms,remote cause,et al to diagnose and treat pediatric epilepsia,and procured positive curative effect.It will not only raise the level of treatment based on syndrome differentiation,but also have significant meanings in the objectivization of treatment based on syndrome differentiation of Traditional Chinese Medicine.

This article summarized the definition,clinical manifestation,diagnosis and the development in research of Panlindromic Rheumatism(PR).According to the clinical characteristics of PR,we considerd that it was very much like "panodynia" in traditional Chinese medicine(TCM) as described in Inner Canon of Huangdi.It discussed the pathogenesis,the theorical source,the diagnosis and treatment of panodynia further.And it suggested that the treatment of panodynia based on syndrome differentiation should be different in the acute and the chronic phase.In the acute phase,principle of removing heat,expelling wind,eliminating dampness and freeing the connecting channels should be applied while in the chronic phase principle of supplementing the spleen and boosting the lung,eliminating dampness and clearing away the phlegm rheum,supplementing the liver and boosting the kidney,supplementing yin and clearing away heat,warming the spleen and recuperating the kidney should be applied respectively according to different clinical manifestation.The theory of "To treat the one going to be sick not the one already sick" in the Inner Canon of Huangdi is implied in the paper.We hope this paper may arouse intensive discussion and more research for panodynia and the relation between panodynia and PR.

Objective: A traditional Chinese medicine(TCM) transformed from Jian Er Ⅱ,Cong Er capsule was studied in protection against age-induced degeneration in cochlear spiral ganglion neurons and auditory nerve fibers in C57 BL /6J mice.A possible protective mechanism was also discussed.Methods : 40 neonatal C57 BL /6J mice were randomly divided into 2 groups with an average of 20 animals in each group.The animals in control group were fed with regular mouse feedstuff and regular water after ablactation,while animals in experimental group were fed the same mouse food after ablactation,but drink the medical solution of Cong Er capsule instead of regular water from two months of age.Animals were terminated at 7 months of age.The cochlea were removed and processed for a series of modiolus sections.The density of spiral ganglion neurons in Rosenthal's canal in different turns was counted,and the auditory nerve fibers in habenula perforata at basal turn and apical turn were also quantified respectively.Statistical comparative analysis was performed between the two groups.Results: Density of spiral ganglion neurons in cochlear basal turn in control group was significantly reduced.In survival ganglion neurons,an obvious degeneration was observed in control group.The number of auditory nerve fibers in cochlear basal turn also decreased.In contrast,Cong Er capsule treated animals had an increase in survival ganglions and auditory nerve fibers,especially,a significant difference was seen in density of spiral ganglion neurons in the basal turn between the two groups(P

From the aspects of formation mechanism,illness position character,disease attribute and laws and prescriptions of heat excess accumulated in chest,the author gave a profound analysis of the internal relations between heat excess accumulated in chest and the sanjiao fu syndrome.Furthermore it proved sanjiao fu viscera's objective existing and its independent significance from treatment based on syndrome differentiation.

In view of Inner Canon of Huangdi,deficiency of heart-QI and blockage of blood circulation is one of basic physical features in senile people.The senile diabetics have more risks in developing into pathogenesis character of deficiency of qi and blood stasis.In Clinic,it could be found by macroscopic syndrome and microcosmic examination.So we prefer that benefiting Qi for activating blood circulation method could be used to amelioration heart systole and diastolic function in elderly diabetes patients to improve their life qualities.

Objective:To probe the effect of Alisol Monoacetate A and Alisol Monoacetate B on the synthesis and metabolism of cholesterol in HepG2 cell line.Methods:Controlled with Lipitor,different concentration of Alisol Monoacetate A and B were added to HepG2 cell line model,then collected and detected the contents of cholesterol in the cell lysate and cultured medium after 24h's cultivation.Results:The cytotoxicity of Alisol Monoacetate A and B appeared at least 10% when its concentration was higher than 10?M,more than 70% when its concentration was 50?M.The contents of cholesterol in HepG2 cell lysate increased from 24.4,26.7,32.3 and 38.3?g/mg protein corresponding with the concentration of 0?M,3?M,10?M and 20?M respectively,which showed the positive dose-effect relationship.However,the contents of cholesterol in the cultured medium manifested no difference.Conclusion:Alisol Monoacetate A and B could enhance the metabolic activity of mitochondria and increase the synthesis of cholesterol in HepG2 cell line.