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The prevalence of obesity,type 2 diabetes,and other chronic non-communicable diseases is increasing rapidly world-wide.Most recent epidemiological data showed that China is now in an era of obesity,and under a huge burden of the complications related with obesity,diabetes,as well as cerebral-and cardiovascular disorders.Strenuous efforts,comprehensive strategies,effective measures,and practical solutions must all be taken to combat against these chronic diseases.

Objective To investigate the effect of hyperoxie liquid on neuron apoptosis in rabbit with traffic brain injury. Methods Rabbit models of brain injury were established by screening suit-able striking intensity and supplied respectively with hyperoxic liquid for 25, 50, 75 and 100 ml each day to observe the respiratory control rate(RCR) of mitochondria, mitochondria membrane potential (MMP), apoptosis rate of neurocytes and NSS grade.Meanwhile, non-intervention group and control groups were set.Results The rabbit model made by striking velocity of 72 km/h was selected as the study object.MMP, RCR, phosphate/oxygen ratio(P/O), oxygenated phosphate rate(OPR) and apopto-sis rate of neurocytes and NSS grade in control and treatment group showed statistical difference compared with non-intervention group(P<0.05).MMP, RCR, P/O and OPR in 100 ml hyperoxic liquid treat-ment group were higher than those in 75 ml hyperoxie liquid treatment group(P<0.05), but the apopto-sis rate of neurocytes and NSS grade showed no statistical difference(P>0.05). Conclusion Intra-venous hyperoxic liquid infusion can decrease apoptosis rate of neurocytes, as indicates that hyperoxic liq-uid affects apoptosis of neurocytes and hence ameliorates prognosis mainly by intervening respiratory func-tion of mitechondria.

Objective To study the relationship between the aged retirees' group's body mass index(BMI)distribution characteristics and relative cardiovascular diseases risk tactors.Methods One thousand three hundred and forty-three retirees in health medical examination were tested for systolic pressure, diastolic pressure,serum triglyceride,total cholesterol and fasting blood glucose.Groups with different BMI and different genders were tested for their mortality.Results The detective rates of BMI insufficiency,normal,overweight and obesity were 6.18%,51.67%,35.52%and 6.63%respectively.There was no statistic significance between different genders.The prevalence rates of hypertension,hyperlipidemia and diabetes mellitus(DM)were 46.09%,46.91%and 7.45%respectively.It showed that the prevalence rates of male hypertension and hyperlipidemia were significantly above those of the female's(P<0.05).As the BMI increased,hypertention,hyperlipidemia and DM rates increased too,and obviously increased in overweight group compared to normal BMI group(P<0.05).The detective rate of cardiovascular disease increased correspondingly with the increase of BMI.Conclusion BMI increasing is the important vascular relative risk factor for the aged retriee.

Objective To investigate the efficacy of flupentixol and melitracen(Deanxit) in treatment of non-erosive reflux disease(NERD) and non-responding to proton pump inhibitor. Methods Fifty eight NERD pa-tients were randomly divided into two groups, the treatment group (n = 29) and control group (n = 29). Patients in control group were given esomeprazole 40 mg qd. Patients in the treatment group were given the same drug plus Deanxit 1 Tab qd. The clinical effect was evaluated and scored by Hemihon Anxiety Rating Scale (HAMA) after 4 weeks. Results The total efficacy rate of the treatment group was higher than control group (P < 0.01),and HAMA was lower in the treatment group than in control group (P < 0.01). Conclusions Adjuvant treatment of Deanxit combined with esomeprazole is effective to NERD patients who did not respond to proton pump inhibitor, can greatly improve anxious disorders.

According to the texts of Baihu Jia Renshen Decoction in the books of Maijing,Qianjin Yaofang,Qianjin Yifang,Taiping Shenghui Fang,Hxin Fang,and Jingui Yuhan Jing,the author drew the following conclusions:Baihu Jia Renshen Decoction in the present Shanghan Lun was very likely the written error Of Baihu Decoction,which was more close to the original meaning of Zhang Zhong-jing.From the period of Sui and Tang Dynasty,doctors had gotten new experiences in their practices.They added Ginsen into Baihu Decoction and named the new decoction"BaihU Jia Renshen Decoction",which was still in use today.Although there was not intrinsically difierence between Baihu Decoction and Baihu Jia Renshen Decoction,while the saying of"adding Renshen or not,should be decided by patient's Yuanqi"by doctor Shu Chi-yuan in Qing Dynasty had a significant impact.The erroneous views by some recent scholars can't be complied with,who advocated that the four main symptoms of Baihu Decoction syndrome should belong to syndrome of Baihu Jia Renshen Decoction according to the original texts in Shanghan Lun.

Objective To investigate the changes of myocardial ATPase activity and plasma tumor necrosis factor- alpha (TNF- a) levels in rats with acute craniocerebral injury (ACI).Methods Sixtyfour male SD rats were randomly (random number) divided into sham group and model group.The observation intervals were set at 2 h,6 h,24 h and 72 h after ACI (n =8,at each interval).ACI model was established in rats by free falling objects hitting skull.Plasma levels of cardiac troponin Ⅰ (cTnⅠ) and TNF-αwere determined by using enzyme -linked immunosorbent assay (ELISA).And the myocardial Na +-K+ -ATPase and Ca2+ -ATPase activity changes were determined by colorimetric method.Then the pathological change of myocardium with HE staining were observed under light - microscopy.Results Plasma cTnⅠ and TNF-α levels increased (P ＜ 0.05),while myocardial Na+-K+-ATPase and Ca2+- ATPase activity decreased in the rats with ACI (P ＜ 0.05 ); There was a negative correlation between myocardial Na + -K + -ATPase、Ca2 + -ATPase activity and plasma Ievels of cTnI ( r =0.357,r =0.557,P ＜ 0.05),and positive correlation between plasma levels of TNF-α and cTnⅠ ( r =0.920,P ＜ 0.05 ).Vacuolar degeneration and necrosis with inflammatory cell infiltrates of myocardium were observed under light -microscopy.Conclusions ACI can lead to myocardial injury,resulting in increase in plasma cTnⅠ and TNF-αand decrease in myocardial ATPase activity.Decrease in myocardial ATPase and increase in TNF-αmay involve in the pathogenesis of myocardial injury after ACI.

Separations of neurotransmitters such as dopamine (DA), ser otonin (5-HA), norepinephrine (NE) and epinephrine (E) were performed successf ully using a homemade electric field modulated capillary electrophoretic system, which could offer both radial and axial electric fields with only one high volt age power supply. DA and 5-HT were eluted simulaneously and could not be resolv ed in 0.01 mol/L phosphate buffer at pH 2.5. Alcohol additives, such as methanol , ethanol or 1-propanol were added to the buffer to change the solvation shell of the solutes, which changed their effective sizes and electrophoretic mobiliti es of the solutes accordingly. The optimum composition was a buffer of 20% (V ／V） 1-propanol, with resulted resolutions 0.74 (DA/5-HT), 0.56(5-HT/NE) and 0.77 (NE/E). If a positive radial voltage of 6.6 kV was applied, the resolut ions were improved to 1.48, 0.71 and 1.32, respectively.

In recent years the incidence rate of tuberculosis (TB) has gone up.It was estimated that 1/3of people had asymptomatic latent tuberculosis infection globally.The current widespread use of Bacillus calmetteguerin (BCG) vaccine program against tuberculosis in children has a good preventive effect,but due to the limited duration of the immune responses induced by BCG,there also had situation of prevent failure,so researchers begin to explore new TB vaccines,such as live attenuated mutant strains,subunit vaccines and DNA vaccines,and achieved certain results.For the pure protein derivative tuberculosis skin test positive and immunosuppressed children,in addition to active immunization would also need anti-TB medicine for chemoprophylaxis.

Objective To probe into the relationship of self-management behavior and hope level in patients with coronary heart disease after percutaneous coronary intervention (PCI).Methods The research instruments included three questionnaires:the Coronary Artery Disease Self-management Scale,the Herth Hope Scale and the demographic characteristics of respondents.Results Self-management behavior was in medium level and it was necessary to be improved.The total score of self-management behavior was positively correlated with hope level.Conclusions Medical workers should fully understand the status of selfmanagement behavior,and promote desirable self-management behavior through increase of hope level.