As is well known, MicroRNA is one of the keys of regulating cell differentiation and metabolism, even body growth and development.In these few years, great progresses of MicroRNA have been made in lung development and the progressive mechanism of lung disease as well as the diagnosis and treat of lung disease such as lung cancer and chronic obstructive pulmonary disease.This review summarizes the latest progresses in the domain of MicroRNA about lung disease.

To study the dynamic relationship of total health expenditure and economic growth so as to provide references for designing health economic policies. Methods: Using the regression models with multiple structural changes to estimate the structural change point of model parameter. Results: Compared to the elastic coefficient of economic growth, the total health expenditure and social health expenditure remained stably, the elasticity coefficient of government spending on health increased after decreased while elastic coefficient of personal spending health costs decreased after increased. Conclusion:In the early years of 1990s, the responsibility of government in health care financing funding weakened, which led to the increasing personal expenses. The situation began to reverse since 2004.

In recent years, many studies have claimed that the intrauterine infection is one of the most common causes of cerebral palsy. Cerebral palsy is associated with the brain injury directly or indirectly. With the direct mechanisms including breakdown of infected nerve cells of the mouse by intrauterine infection,hydrocephalus, dilation of the cerebral ventricles and ependymitis being illuminated uninterruptedly, researches of the indirect mechanism in cerebral palsy caused by intrauterine infection become the hot issue in the domain.Besides the inflammation mediators theory and down-regulated expression of development of the nervous system related factors, there were still several important elements which can cause brain damage such as placental excretive hormone imbalance, change of activity of Notch signaling and gene mutation/deletion and so on.Mechanisms and the interaction between them built up network effect.

Objective To investigate leukotriene B4 secretion from DC and expression of its receptor,BLT(LTB1,LTB2).Methods Bone marrow(BM)-derived DC from healthy Balb/c mice were incubated with rmGS-CSF and rmIL-4,and then stimulated with LPS.Light microscopy and flow cytometry were used to identify DC,ELISA and RT-PCR methods were used to detect LTB4 secretion in culture supernatant and mRNA expression of BLT(BLT1,BLT2) in immaturation and mature DC,respectively.Results LTB4 concentration was(10.667?(2.394)ng/L)、(7.089?(1.810) ng/L)、(3.222?(0.995)ng/L) and(14.217?(3.396)ng/L) in 2,4 and(6 d)(immaturation) and(8 d) (maturation) respectively.LTB4 level decreased progressively during DC differentiation.LTB4 level in mature DC was higher than that in immature DC(P

Objective:To investigate the expression of E2F3 mRNA in bladder urothelial carcinoma and normal bladder urothelial tussue to explore its relationship with the genesis and progression of bladder urothelial carcinoma.Methods:The expression of E2F3 mRNA in 34 cases of bladder urothelial carcinoma and 19 cases of normal bladder urothelial tussue was examined by RT-PCR.Result:The positivity rates of E2F3 mRNA in bladder urothelial carcinomas and normal bladder urothelial tussues were 47.1%(16/34) and 0%(0/19) respectively.The expression level of E2F3 mRNA in bladder urothelial carcinomas was significantly higher than that in normal bladder urothelial tussues(P

Objective:To investigate the relationship between TGF-?1 and the contents of IL-6 and IL-8 in peripheral blood after the penetrating keratoplasty in rat.Methods:Rat model of penetrating keratoplasty was established.ELISA assay was used to detect the contents of IL-6 and IL-8 in the peripheral blood at the first week,second week,third week,and fourth week postoperatively.Results:Compare with the control groups and self groups,the expression level of IL-6 and IL-8 in all experimental groups markedly decreased at different periods postoperatively(P

[Objective]Combing the application of ginseng in the past physicians to make readers understand the efficacy of ginseng,and to be flexible in order to better serve human health.[Methods]Through consulting the ancient books of materia medica,the understanding of the ancient physicians and the application of hanren formulae were summarized and analyzed.[Results]Although the ancient physicians of the past believed that ginseng was subject to tonify five organs,quiet spirt,set soul,stop fright,remove pathogen,in addition to bright eye,happy,educational. long taking makes people fit and live longer,but with the development of the times,the Han dynasty in to nifying Qi torelieve thirst,tonify Qi for deficiency,the Tang dynasty in tonifying heart Qi,benefiting heart spirit,the Song dynasty in complement,benefiting Qi,the Ming dynasty in benefiting qi,Qing dynasty in tonifying Qi and Yin,modern in emergency first aid application.[Conclusion]Through the analysis of the application of ginseng in past dynasties,the complement ginseng can be more widely used in clinic,and better serve human health.

To investigate the effects of Tacrolimus ointment on patients with erosive oral lichen planus. A total of 62 cases were collected and divided into two groups randomly: 31 cases were treated with Tacrolimus ointment (treatment group), and 31 cases with clobetasol propionate ointment (control group). There was no significant difference between two groups of the effective rate and side-effect occurrence during the therapy, and relapse rate within six months after treatment. The results of the present work demonstrate that Tacrolimus ointment is an effective therapy for oral lichen planus.

Objective To investigate the significance of levels of IL-8,TNF-α in serum of patients with aplastic anemia(AA).Methods Serum levels of IL-8 and TNF-α in 45 patients and 30 normal controls were measured by enzyme linked immunosorbent assay.Results The serum levels of IL-8,TNF-α increased significantly in AA and acute AA(AAA)group than in the control group(P＜0.05),there was no statistical significance between chronic AA(CAA)group and the control group(P＜0.05),and the levels in AAA group were much higher than in CAA group(P＜0.05).The serum level of IL-8 was positively related to TNF-αin AA group(r=0.682,P＜0.05).Conclusion There are immunological disorders in patients with AA and the overproduction of IL-8,TNF-α might be involved in the immunopathogenesis of AA,AAA.

Stenosis or occlusion of vertebral artery origin is one of important reasons of posterior circulation ischemia. Vertebral artery stenting can reduce posterior circulation ischemia in patients with vertebral artery origin stenosis. Restenosis after stenting is an important reason influencing the long-term efficacy.This article reviews treatment approaches of vertebral artery origin stenosis, restenosis after stenting and the related factors.