Ia antigen (HLA-DR in rnan) is confined to the Langerhans cells and indeterminate cells in the normal epidermis in man. However the keratinocyte express la antigen in a variety of dermatoses. IFN-r (irnmune interfcron), known as macrophage activating factor, has been shown to induce Ia antigen expression in a wide variety of cell types. However the Ia antigen induced by 1FN-r is inhibited PGE2, a product of cyclooxygenase pathway of arachidonic acid metabolism. LTB4, a product of lipoxygenase pathway, can replace the IL-2 requirement for IFN-r production in the lymphocytes. There are three main morphalogical patterns of Ia antigen staining in the epidennis. Staining of the basal cells, staining in the mid epidermis in Malphigian layer and staining throughout the epidermis. The staining of Ia' keratinocyte was found to be confined to the lesional area of contact hypersensitivity reaction, graft vs host disease, and lichen planus. la+staining to extend beyond the lesional area was also seen in the study on turberculosis and leporsy.
Arachidonic Acid ; Dermatitis, Contact ; Dinoprostone ; Epidermis ; Graft vs Host Disease ; Histocompatibility Antigens Class II ; Interleukin-2 ; Keratinocytes* ; Langerhans Cells ; Leukotriene B4 ; Lichen Planus ; Lipoxygenase ; Lymphocytes ; Macrophages ; Metabolism ; Prostaglandin-Endoperoxide Synthases ; Skin Diseases

No abstract available.
Animals ; Dermatitis, Contact* ; Dinitrochlorobenzene* ; Guinea Pigs* ; Guinea* ; Spleen*

Porphyria is a rare metabolic disorder in this country and a few cases of acute intermittent porphyria has been reported. We observed a case of porphyria cutanea tarda associated with liver cirrhosis. The patient was 61-year-old farmer with heavy alcoholic habit. He had been suffered from skin fragility and photosensitivity for 3 years. His face color was slate blue and sclerdermoid appearance noted especially on the cheek. Bullae, which is healing slowly and followed by atrophic pigmented scars, were developed on the dorsum of hand and feet after receiving trivial trauma and massive alcohol intake. None of his family members has similar symptoms. Urine specimen showed port-wine coIor and fluoresced pinkish under the Wood's light. Serum iron level was markedly elevated (400 microgram%). The other abnormal findings of liver function test were BSP retention (16%/45min.), elevated SGOT (198 unit) and SGPT (80 unit) levels. Esophagram revealed suspicious of varices and liver scanning showed cirrhotic changes. Skin biopsy specimens taken from the cheek and dorsum of hand showed sclermoid changes and subepidermal bulla. Liver biopsy disclosed mild degree of cirrhotic changes.
Alanine Transaminase ; Alcoholics ; Aspartate Aminotransferases ; Biopsy ; Cheek ; Cicatrix ; Foot ; Hand ; Humans ; Iron ; Liver ; Liver Cirrhosis ; Liver Function Tests ; Middle Aged ; Porphyria Cutanea Tarda* ; Porphyria, Acute Intermittent ; Porphyrias* ; Skin ; Varicose Veins

CsA per os during the early sensitization period caused potentiation of 14-day shin response and this response was enhanced in group D, CsA given on days 3 7 Thereafter, suppression of CHS began in group E, CsA was given on days 6- 1G, and this tendency continue to the time of full sensitization of guinea pigs (group G). 27701173 We report herein a case of alopecia mucinosa in a 46-year-old male. He had a coin-sized erythematous hairless plaque on the parietal area. Histopathologic examinations, including much stains, showed typical findings of alopecia mucinosa. Thc present case, appeared on the scalp, might be an acute benign type of the disease.
Animals ; Coloring Agents ; Cyclosporine* ; Dermatitis, Contact* ; Dinitrochlorobenzene* ; Dronabinol ; Guinea Pigs* ; Guinea* ; Humans ; Male ; Middle Aged ; Mucinosis, Follicular ; Rabeprazole ; Scalp

There have been published manuscripts which fully suggest that there may be a topographic variance of contact sensitivity in experimental animals such as guinea pigs, hamsters and mice, probably due to a large extent to the topographic difference of Langerhans cell population and to a little extent to impact on the induction site. This assay was done to establish the possibility of involvement of a certain topographic variance in contact sensitivity reaction. Three different anatomical sites were chosen for the induction in three groups of five guinea pigs: the conventional site of the nuchal region, and the sacral aod. ahdominal skin regions. For the elicitation, two different concentrations of DNCB were applied on three sites along both sides of the spine in the back. The contact sensitivity reaction elicited by DNCB in the group of the nuchal abdominal skin induction was definitely stronger at the site closer to the nuchal region than that found at sites closer to the sacral regior. but all animals of the group sensitized on the sacral region showed comparatively uniform reaction. Zvidently, contact sensitivity reaction is influenced mainly by topographic variance hut shows a litte difference depending upon induction sites.
Animals ; Cricetinae ; Dermatitis, Contact* ; Dinitrochlorobenzene ; Guinea Pigs* ; Guinea* ; Mice ; Sacrococcygeal Region ; Skin ; Spine

A case of familiar benign chronic pemphigus is reported. A 41 years old housewife has recurrent history of developing grouped vesicular eruptions with erythematous erosion on the intertrigenous area since 29 years of her age. The lesions were used to aggrevated in summer and improved in autumn. Familiar history revealed same disease of her grand mother, father, 44 year old elder sister and 39 year old younger sister. All of whom had similar clinical signs and symptoms. Routine physical and laboratoryfindings were within normal limits. The histopathological findings, from vesicular eruption of the lateral aspect of neck, showed multilocular suprabasal clefts with acantholsis, villi formation and hyperkeratosis. The lesions were-improved hy the local application of corticosteroidoid ointment only.
Adult ; Fathers ; Humans ; Mothers ; Neck ; Pemphigus, Benign Familial* ; Siblings

The sunlight protecting effect of indomethacin (IM) was compared with topical sun screening agents of sun protecting factor(SPF) 2 and SPF 4, and it was found that IM stood in between SPF 2 and SPF 4. (vehicle of IM) painted skin was 4.8 J/cm and MED skin was 37.5 m J/cm. with UVB of PED painted was compared with topical 2 and SPF 4, and it was MED with UVA of PED with UVB of PED painted skin was 37 5 m J/cm.
Indomethacin* ; Mass Screening ; Paint ; Skin ; Solar System ; Sunlight

Multiple basal cell epithelioma on the face is a rare disease and the lesions are hard to indistinguish from multiple trichoepithelioma. The 15-year-old school girl has been suffered from multiple small pea-sized, slightly waxy appearing skin lesions on the face for 4 years. She has no history of arsenic ingestion; irradia tion and previous dermatoses. Physical examination and X-ray films (chest, mandibule and skull) showed no pathological findings. Biopsy findings revealed basal cell epithelioma cells.
Adolescent ; Arsenic ; Biopsy ; Carcinoma, Basal Cell* ; Eating ; Female ; Humans ; Physical Examination ; Rare Diseases ; Skin ; Skin Diseases ; X-Ray Film

A case of hereditary anhidrotic ectodermal dysplasia associated with atopic dermatitis in 16 month old male is reported. He has been suffered from multiple symptoms of anhidrosis, hypotrichosis, anodontia and atopic dermatitis. The skin showed pale, shiny, thin and dry and hairless on whole body except in the scalp. Without sweat gland and flattening of epidermis on skin biopey is compatible with an hereditary anhidrotic ectodermal dysplasia.
Anodontia ; Dermatitis, Atopic ; Ectodermal Dysplasia* ; Epidermis ; Humans ; Hypohidrosis ; Hypotrichosis ; Infant ; Male ; Scalp ; Skin ; Sweat Glands

Pityriasis lichenoids et varioliformis acuta(Mucha-Habermann disease) is a distinctive eruption of unknown cause. A case of pityriasis lichenoides et varioliformis acuta, 24-year old male, was seen at dermatology department, St. Mary's hospital, Catholic Medical College. The eruption was ;olymorphic, consisting of pink papules, Some of the papules had a fine brown scale, while others became hemorrhagic and vesicular, leading to varioliform scarring on tumk and extremities except palms and soles without subjective symptoms. Histopathological geatures were hyperkeratosis, parakeratosis focal obliteration of the dermoepidermal junction by lymphocytes extending from the dermal papillac and invading the lower dermis, heaby perivascular lymphocytic infiltration diaperdesis of red blood cells into the corium and opidermis, and necrotic crust. The lesion was completely cleared with 10 mg of methotrexate by mouth twic a week for 4 weeks.
Cicatrix ; Dermatology ; Dermis ; Erythrocytes ; Extremities ; Humans ; Lymphocytes ; Male ; Methotrexate ; Mouth ; Parakeratosis ; Pityriasis Lichenoides* ; Pityriasis* ; Young Adult