Glaucoma is an group of ocular disease associated with the degeneration of retinal ganglion cells and it finally causes vision loss.Primary open angle glaucoma (POAG) is a main type of glaucoma worldwide.The primary reason of POAG is elevated intraocular pressure (lOP) caused by the degeneration or dysfunction of the trabecular meshwork (TM).Recent studies showed that stem cell-based therapy becomes a promising approach to treat the degenerative diseases,including POAG.Among multiple types of stem cells,induced pluripotent stem cell (iPSC) is the one with the most clinical potential due to its autologous derivation and non-ethical issue.In this paper,we summarized the encouraging therapeutic effects of iPSCs on POAG from different species,different etiological factors and different pathological stages.Although these encouraging studies suggest that iPSC is a fabulous stem cell type to regenerate the damaged tissue,more efforts are required for clinical application.In addition,we discussed several solutions to improve the safety of iPSCs and provided potential approaches to improve the therapeutic efficiency and specific targeting.Answering these questions will help us to better understand the characteristics of iPSCs and promote the development of bench to bedside research.

ObjectiveTo assess the reliability and validity of the Chinese version of the rejection sensitivity questionnaire(RSQ).Methods813 college students were investigated with RSQ and each caregiver was retested 4 weeks later.Results ( 1 ) All items had good discrimination.(2) Exploratory factor analysis showed the Chinese version of RSQ consisted of three factors which could explain 45.986％ of the total variance.Confirmatory factor analysis indicated that there was high fitting degree between the three-factor model and the two-dimension model.They were significantly correlated with RSQ total score( r =0.661 ～ 0.851,P ＜ 0.001 ).(3) The Cronbach's alpha coefficient was 0.809.The three factor's Cronbach's alphas were 0.684,0.631 and 0.534 respectively.The test-retest coefficient was 0.892 (P ＜ 0.001 ).ConclusionThe Chinese version of RSQ is a reliable and valid measurement for assessing the rejection sensitivity of the Chinese college students.

Xinshu (BL 15), Feishu (BL 13), Pishu (BL 20), Ganshu (BL 18), Shenshu (BL23) and Geshu (BL 17) were selected and the needles were retained for 30 min. After the needles were taken out, cupping method was applied on each acupoint. In the treatment of total 36 cases of hyperlipidemia, the results showed remarkable effect in 22 cases, effect in 9cases and failure in 5 cases, and the total effective rate in 86.1%.

Objective To explore the application value of CT value histogram in differential diagnosis between primary hepatoma and other space-occupying lesions in liver.Methods From 2012 to 2013,the imaging data in 243 patients with different isolated space-occupying lesions in liver were analyzed retrospectively who underwent both enhanced and unenhanced abdominal CT scans. The lesions were confirmed as hepatic cyst,hepatic hemangioma or primary hepatoma by pathological and other clinical proofs and divided into 3 groups.The histograms of plain scan and post-contrast triphases were drawn respectively using an attached picture-making software.Relevant data of the histograms were analyzed and compared using the SPSS among three groups.Results The CT value histograms of hepatic cysts,hemangiomas and majority of hepatomas presented normal distribution curves.Negative skewness distribution curve was showed in the tumor within necrosis and liquefaction,whereas the positive curve was showed in hepatoma with more calcification.Some significant differences in the Mean,SD,Max,Min,and R values were confirmed.Conclusion Skew-ness distribution curve has a relative high specificity in diagnosis of primary hepatoma.Both dramatic decrease of the Mean value in delayed phase and obvious increase of the R value in plain scan suggest the possibility of primary hepatoma.

Professor Macer summarizes the essence and concepts of bioethics with love as the universal ethical basis,but it effective resources and evidence proves to be limited.In fact,the "love" could be the motive of ethics rather than the basis of ethics.For the origins of ethics are vastly related with compassion and mercy.

Objective To study the factors influencing the assay of ? 1 antitrypsin(? 1 AT) bioactivity. Methods Various concentrations of PEG(MW, 4000), sucrose, sodium citrate and ethanol were added before determining ? 1 AT activity. Results ? 1 AT activity increased approximately 100% compared with the controls when the PEG concentration reached 20%. Conclusion PEG concentration influences the ? 1 AT activity assay.

Adaptor Proteins, Signal Transducing ; genetics ; Bone Marrow Diseases ; genetics ; pathology ; DNA Mutational Analysis ; DNA-Binding Proteins ; genetics ; Exocrine Pancreatic Insufficiency ; genetics ; pathology ; Glucose-6-Phosphatase ; genetics ; Humans ; Leukocyte Elastase ; genetics ; Lipomatosis ; genetics ; pathology ; Mutation ; Neutropenia ; congenital ; genetics ; Proteins ; genetics ; Transcription Factors ; genetics

Along with detection techniques develop continuously, sensitivity of cardiac troponin (cTn) detection becomes higher and higher.It improves diagnostic rate of patients with acute coronary syndrome,but accompanied by specificity reduction.Therefore, it's necessary to identify non-coronary heart disease that may lead to increase of cTn level.The present article made a review on manifestation of cTn in non-coronary heart disease.

Objective To observe the clinical nursing effect of doxofylline in the treatment of bronchial asthma and intervention. Methods 98 cases of bronchial asthma patients in our hospital from June 2014 to November 2016 received as the object of nursing, the patients were divided into control group and treatment group, 49 cases in each group, using multiple theophylline treatment, the control group was given routine care, the treatment group on the basis of the comprehensive nursing, the clinical effects of two groups were compared before and after, adverse reactions and treatment of pulmonary function. Results The total effective rate of treatment group was 89.80％, control group total effective rate was 73.47％, the total effective rate of treatment group was significantly better than the control group (P<0.05), the difference was statistically significant; the treatment group adverse reaction rate was 6.12％, the control group adverse reaction rate was 18.37％, incidence of adverse reaction in treatment group was significantly better than the control group (P<0.05), the difference was statistically significant; two groups of patients after treatment of FEV1, FFV1/FVC and PEF indexes were improved, but the treatment group was significantly better than the control group (P<0.05), the difference was statistically significant. Conclusion Doxofylline the treatment of bronchial asthma in the process of the comprehensive nursing has a good effect, and less adverse reactions. It is worthy of clinical application.

Gene therapy of spinal cord injury (SCI) is the most promising method compared with the others, because it doesn't involve the problems of resource and higher exclusion which respectively exists in fetal nerve transplantation and peripheral nerve transplantation. There are two ways of gene therapy to be chosen: one is to transfer objective genes to the target-cells in vivo directly; the other is to transfer objective genes to one proper kind of transplantable cells firstly, then graft the highest expressing cells to the target-cells in vivo. To realize the transfer of genes to cells, two measures are used in common: physical or chemical measure such as micro infection et al and biochemical measure i. e. gene modified defective virus. Although there are some questions unresolved in this field, the clinical value of gene therapy of SCI in the future is depended.