Human autoimmune uveitis encompasses a diverse group of common ocular inflammatory diseases.Unknown factors trigger the breakdown of self-tolerance and subsequently lead to the irreversible vision impairment.So the explore and research has never ceased for a long time.Previous study indicated that T helper lymphocyte 1 (Th1) plays a key role in the pathogenesis and development of human autoimmune uveitis.But recently accumulating evidences from both animal and clinical studies suggest that Th17 participates in the pathological mechanism of human autoimmune uveitis.Studies showed that Th1 and Th17 determine the pathological process by the regulation signal of specific cytokines and transcription factors.More and more evidences revealed that Th1 and Th17 are the predominant influences in induction of uveitis.Unveiling the roles of Th1/Th17-related cytokines will help to elucidate the mechanism and progression of uveitis.Recent findings of Th1/Th17-related cytokines regarding pathogenesis and regulation attributed in uveitis were summarized and the novel viewpoint of treatments was discussed.

Objective To explore the clinical value of the combined detection of tumor type M2 pyruvate kinase (tumor M2-PK),tissue polypeptide specific antigen (TPS)and carcino-embryonic antigen (CEA)in the diagnosis of colorectal cancer.Methods The serum level of TPS and CEA,and the level of tumor M2-PK in fecal were detected in 74 patients with colorectal cancer and 60 healthy volunteers in our hospital.The sensitivity,specificity and accuracy were performed the comparative analysis between the single detection and the combined detection.Results The serum levels of TPS,CEA and the level of tumor M2-PK in fecal in the colorectal cancer observation group were significantly higher than those in the healthy control group (P <0.05).There were signifi-cant differences in the sensitivity,specificity and accuracy of TPS,CEA and tumor M2-PK between and the combined detection (P <0.05).In the comparison among the single detection of 3 tumor markers and between the single marker detection with the combined detection,the sensitivity,specificity and accuracy of any single marker measurement was lower than that in the combined detection of 3 markers.Conclusion The combined detection of TPS,CEA and tumor M2-PK can improve the sensitivity,specificity and accuracy in diagnosing colorectal cancer.

PurposeTo evaluate multislice spiral CT (MSCT) imaging features of gastric heterotopic pancreas.Materials and Methods MSCT features in 15 patients with pathology confirmed gastric heterotopic pancreas were retrospectively reviewed, including location, shape and border, size, CT value of gastric heterotopic pancreas and the normal pancreas.Results Twelve lesions were located in the gastric antrum, 11 were in the greater curvature. Intraluminal growth was found in 11 cases. 10 lesions were ill-defined. The mean longitudinal diameter (LD)/short diameter (SD) of the lesion was 1.89. The measurement showed high agreement with 0.99 ICC of LD and 0.98 ICC of SD. All lesions showed homogeneous and continuous enhancement, of which 4 cases showed surface dimpling. The plain and the portal vein phase CT values of gastric heterotopic pancreas and the normal pancreas had no significant differences (t=0.402 and—1.050, P>0.05), while the arterial phase CT value between gastric heterotopic pancreas and the normal pancreas were significantly different (t=3.13,P<0.05).Conclusion Gastric heterotopic pancreas demonstrates typical imaging features on MSCT which are helpful in the diagnosis and differential diagnosis.

Undergraduates born in the later 1980's have their own characteristics: they possess larruping individuality and have strongly self-consciousness;at the same time they long for being respected but they are sensitive and frail.To instruct them correctly,a teacher in charge of a class should have high quality as a teacher and proper working policy as well.Under this condition,a teacher in charge of a class can communicate with students effectively and be in excellent charge of a class.

0.05). But the curative rate had significant difference between them (P0.05). Conclusion Regulating the balance of TXB2 and 6-Keto-PGF1?,and inhibitng activation of platelet may be one of the acting ways of Jiawei Shaoyao Decoction.

Cytotoxic T lymphocytes (CTL) derived from the spleen of SW-1 mice immunized in vivo with syngeneic mouse leukemia clonal cells LAC-1 were cultured in TCGF containing media and tested for cytotoxicity against LAC-1 cells in a routine ~(51)Cr-release assay. The experimental results showed that the CTL cell line was proved to be Thy 1 and Lyt 2, and therefore they were considered to be of T cell lineage. When CTL were expanded in the presence of TCGF, an augmented cytolytic activity in parallel with the increase of Thy 1 and Lyt 2 cells was shown. This cytotoxic T cell line had been maintained in a long-term culture for nearly 1 year and retained the initial reactivity. Specificity studies of the CTL showed that the cell line was highly specific for LAC-1 cells and its parent line L783 Leukemic cells and the cytolytic effect was H-2 restriction. The cytotoxicity of the CTL could be blocked by conventional or monoclonal antibodies against cell surface antigen (TSA) of LAC-1 cells. Antisera against H-2 antigens, shared by LAC-1 cells, also showed blocking activity.

OBJECTIVE To apply the comprehensive interventional measures to manage the clinical application of antibacterials and provide a scientific basis for their management.METHODS Since 2004 we strengthened the propagend a about the hospital infection knowledge worked out the quantification standards about the antibacterial use rate and cost ratio,the interventional measures about the rational use of antibacterials,and made an investigation about antibacterial use rate and cost ratio before and after intervention.RESULTS It indicated the antibacterial use rates before and after intervention and among operated patients had the statistically significant differences.CONCLUSIONS The application of comprehensive interventional measures to manage clinical use of antibacterials could decrease the antibacterial use rate and increase the self-consciousness among clinicians in rational use of antibacterials.

OBJECTIVE:To make an approach to the pharmaceutical care for kidney transplant patients METHODS:Using modern pharmaceutical theory and advanced monitoring method,the pharmaceutical care was carried out in kidney transplant patients,and the results were analysed and evaluated in the light of several cases RESULTS:Pharmaceutical care could raise the living quality of recipients CONCLUSION:It is necessary for kidney transplant patients to carry on pharmaceutical care

Bilingual parallel corpus is a new perspective of English for Specific Purposes (ESP) translation studies. This article set 10 kinds of Gansu genuine bulk Chinese materia medica as the research objects, and collected Chinese-English data about Gansu Chinese materia medica in the authoritative publications for the establishment of English-Chinese parallel corpus on Gansu Chinese materia medica. This article also analyzed the construction concrete steps in detail - corpus design, data acquisition and processing and bilingual corpus parallel and so on, and provided references for English translation of Chinese materia medica.