1.Endoscopic findings of rectal mucosal damage after pelvic radiotherapy for cervical carcinoma: correlation of rectal mucosal damage with radiation dose and clinical symptoms.
Tae Gyu KIM ; Seung Jae HUH ; Won PARK
Radiation Oncology Journal 2013;31(2):81-87
PURPOSE: To describe chronic rectal mucosal damage after pelvic radiotherapy (RT) for cervical cancer and correlate these findings with clinical symptoms and radiation dose. MATERIALS AND METHODS: Thirty-two patients who underwent pelvic RT were diagnosed with radiation-induced proctitis based on endoscopy findings. The median follow-up period was 35 months after external beam radiotherapy (EBRT) and intracavitary radiotherapy (ICR). The Vienna Rectoscopy Score (VRS) was used to describe the endoscopic findings and compared to the European Organization for Research and Treatment of Cancer (EORTC)/Radiation Therapy Oncology Group (RTOG) morbidity score and the dosimetric parameters of RT (the ratio of rectal dose calculated at the rectal point [RP] to the prescribed dose, biologically effective dose [BED] at the RP in the ICR and EBRT plans, alpha/beta = 3). RESULTS: Rectal symptoms were noted in 28 patients (rectal bleeding in 21 patients, bowel habit changes in 6, mucosal stools in 1), and 4 patients had no symptoms. Endoscopic findings included telangiectasia in 18 patients, congested mucosa in 20, ulceration in 5, and stricture in 1. The RP ratio, BEDICR, BEDICR+EBRT was significantly associated with the VRS (RP ratio, median 76.5%; BEDICR, median 37.1 Gy3; BEDICR+EBRT, median 102.5 Gy3; p < 0.001). The VRS was significantly associated with the EORTC/RTOG score (p = 0.038). CONCLUSION: The most prevalent endoscopic findings of RT-induced proctitis were telangiectasia and congested mucosa. The VRS was significantly associated with the EORTC/RTOG score and RP radiation dose.
Constriction, Pathologic
;
Endoscopy
;
Estrogens, Conjugated (USP)
;
Follow-Up Studies
;
Hemorrhage
;
Humans
;
Mucous Membrane
;
Proctitis
;
Radiation Injuries
;
Rectum
;
Telangiectasis
;
Ulcer
;
Uterine Cervical Neoplasms
2.Histamine Bronchial Provocation Test: Timed Tidal Breathing Technique.
Yeon Tae CHUNG ; Kyung Sook WON ; Hae Shim PARK
Tuberculosis and Respiratory Diseases 1994;41(3):270-276
BACKGROUND: The measurement of nonspecific bronchial hyperreactivity is valuable for diagnosis and management of bronchial asthma. Methacholine or histamine is used for the pharmacologic provocation test. Usually a methacholine bronchial provocation test is performed by a dosing technique with counted number of breaths. A dosimeter is indispensable in the dosing technique. Recently a timed tidal breathing technique which dose not need an expensive dosimeter was introduced. We measured the degree of nonspecific bronchial hyperreactivity to histamine using a simple timed tidal breathing technique. METHOD: Forty two healthy volunteers, 12 patients with bronchial asthma(BA), 10 patients with rhinitis(RH) and 10 patients with upper respiratory infection(URI) participated in the study. The subject's nose was clipped and inhalation continued during tidal breathing for 2 minutes via a face mask. FEV1 was measured at 30 seconds, 90 seconds after inhalation and inhalation of next solution was continued until there was a fall in FEV1 of 20%. Histamine PC20 was defined as the concentration at 20% fall of FEV1 and it was obtained from the log dose-response curve by linear interpolation. RESULTS: Inhalation of serial dilution of histamine could be performed in all patients without significant side of effects. The geometric mean±standard deviation of histamine PC20 in healthy volunteers is 8.27±2.22mg/ml, BA group 0.33±3.02mg/ml, RH group 0.85 ±3.24mg/ml, and URI group 1.47±1.98mg/ml. CONCLUSION: Histamine bronchial provocation test using timed tidal breath method is a simple and suitable tool for management of patients with bronchial hyperreactivity.
Asthma
;
Bronchial Hyperreactivity
;
Bronchial Provocation Tests*
;
Diagnosis
;
Healthy Volunteers
;
Histamine*
;
Humans
;
Inhalation
;
Masks
;
Methacholine Chloride
;
Nose
;
Respiration*
3.Pregnancy outcomes following uterince artery and umbilical artery doppler velicimetry.
Yoon Tae LEE ; Yong Won PARK ; Chan Ho SONG
Korean Journal of Obstetrics and Gynecology 1993;36(7):1190-1195
No abstract available.
Arteries*
;
Female
;
Pregnancy
;
Pregnancy Outcome*
;
Pregnancy*
;
Umbilical Arteries*
4.Livedo Reticularis Idiopathica Associated with Mononeuropathy Multiplex Syndrome and Bilateral Ulnar-median Nerve Anastomosis.
Tae Jin CHOI ; Chul Jong PARK ; Jong Yuk YI ; Tae Yoon KIM ; Chung Won KIM
Annals of Dermatology 1996;8(3):218-222
A 31-year-old woman had a livedo reticularis of reticulated, bluish discoloration on both arms and legs for 18 months with a burning pain in the right hand and numbness in both lower legs. The findings of the electromyography were consistent with mononeuropathy multiplex and bilateral ulnar-median nerve anastomosis. A biopsy specimen from the right sural nerve showed perivascular lymphocytic infiltration and occasional myelin digestion chambers, which were consistent with vasculitic neuropathy. We present a patient with livedo reticularis idiopathica associated with mononeuropathy multiplex syndrome who also has bilateral ulnar-median nerve anastomosis.
Adult
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Arm
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Biopsy
;
Burns
;
Digestion
;
Electromyography
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Female
;
Hand
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Humans
;
Hypesthesia
;
Leg
;
Livedo Reticularis*
;
Mononeuropathies*
;
Myelin Sheath
;
Sural Nerve
5.A Case of Multiple Bowen' s Disease in a Leprosy Patient.
Tae Jin CHOI ; Chul Jong PARK ; Jong Yuk YI ; Tae Yoon KIM ; Chung Won KIM
Korean Journal of Dermatology 1995;33(6):1134-1137
We report a case of multiple Bowen's disease associated with leprosy. A 68-year-old man was seen because of slightly pruritic multiple erythematous scaly patches and plaques on the trunk and the both extremities for 5 years. He has been treated for leprosy with many kinds of drugs consisting of the herb medications for over 40 years. He also showed decreased cell-mediated immunity in skin tests. It is considered that depressed cellular immunity may be an important predisposing factor in the development of mutiple Bowen's disease in this case, .although arsenics can not be completetly excluded.
Aged
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Bowen's Disease
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Causality
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Extremities
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Humans
;
Immunity, Cellular
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Leprosy*
;
Skin Tests
6.Nonspecific Empirical Medical Therapy with Acetylcarnitine Effective in Oligoasthenospermic Men?.
Jong Woo KIM ; Jae Seok LEE ; Jeong Su PARK ; Won Tae KIM ; Ju Tae SEO
Korean Journal of Fertility and Sterility 2004;31(3):177-182
PURPOSE: To determine the efficacy of CarnitilR (acetylcarnitine, Hanmi, Korea) therapy in idiopathic oligoasthenospermic men. MATERIALS AND METHODS: Forty-four subfertile men with abnormal semen parameters were treated between March, 2003 and March, 2004 with 3 g of CarnitilR daily for 3 months. Changes in semen parameters were evaluated 3 months after this therapy. RESULTS: The mean age was 34.2 years and the mean follow-up duration was 3.7 months. In asthenospemic patients (n=28), semen analysis before and after CarnitilR treatment showed an increase in volume (2.64+/-1.65 ml vs. 3.10+/-1.60 ml), motility (35.1+/-17.7% vs. 45.9+/-20.4%) and viability (51.4+/-20.3% vs. 59.3+/-13.6%) respectively. In oligoasthenospermic patients (n=16), semen analysis before and after CarnitilR treatment showed an increase in sperm count (10.7+/-54.4 million/ml vs. 38.4+/-32.5 million/ml) respectively. CONCLUSIONS: These results suggested that in idiopathic oligoasthenospermic men the empirical medical therapy with acetylcarnitine may be considered as primary treatment.
Acetylcarnitine*
;
Carnitine
;
Follow-Up Studies
;
Humans
;
Infertility, Male
;
Male
;
Semen
;
Semen Analysis
;
Sperm Count
7.A Case of Angioleiomyoma on the Lip.
Hyun Jeong PARK ; Young Min PARK ; Jong Yuk YI ; Tae Yoon KIM ; Chung Won KIM
Annals of Dermatology 1996;8(1):57-60
It is known in general that neoplasms of smooth mucsle appear very rarely in the oral region, probaly because in the oral region with histopathologic investigations have been reported. This report presents an unusual case of angioleiomyoma that developed on the lower lip of a 48-year the course of one year and the immunohistochemical findings of the angioleiomyyoma are described.
Angiomyoma*
;
Lip*
8.Balanitis Circumscripta Plasmacellularis.
Young Suck RO ; Pyung Won PARK ; Chan Kum PARK ; Hong Yoon YANG ; Young Tae KIM
Annals of Dermatology 1991;3(2):158-163
A 79-year-old man with balanitis circumscripta plasmacellularis(BCP), presenting as an erythematous constricting band of the inner surface of the prepuce encircling the penile shaft is described. The biopsy specimen of the lesion showed, in addition to the typical histologic findings of BCP, increased fibrosis and decreased amount of elastic fibers which correlate well with our clinical observations. Electron microscopic examination revelaed no viral particles or elastic fibers. Immunohistologically, IgG was found to be the major immunoglobulin class in the plasma cellular inf iltrate.
Aged
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Balanitis*
;
Biopsy
;
Elastic Tissue
;
Fibrosis
;
Humans
;
Immunoglobulin G
;
Immunoglobulins
;
Male
;
Plasma
;
Virion
9.A Case of Pseudo-Meigs' Syndrome.
Tae Hyoung PARK ; Young Bok PARK ; Cheol Seong BAE ; Hae Won YOON ; Myung Soo KANG
Korean Journal of Obstetrics and Gynecology 1999;42(10):2386-2390
Meigs' syndrome is defined as a hydrothorax with ascites and a pelvic tumor, both of which resolve on removal of the tumor. Pseudo-Meigs' syndrome is a variant not possessing the original tumor cell types described by Meigs. Both these syndromes should be considered in otherwise healthy women who present with either new or recurrent hydrothorax and ascites. Pseudo-Meigs' syndrome occurs with the clinical triad of (1)ascites, (2)pleural effusion and (3)Brenner tumors, struma ovarii, benign thecomas, extreme ovarian edema, uterine leiomyomas or other benign pelvic tumors. A case of Pseudo-Meigs' syndrome associated with Brenner tumor is presented with a brief review of literatures.
Ascites
;
Brenner Tumor
;
Edema
;
Female
;
Humans
;
Hydrothorax
;
Leiomyoma
;
Meigs Syndrome
;
Struma Ovarii
;
Thecoma
10.Efficacy of doppler umbilical artery velocimetry in the prediction of intrauterine growth retardation and perinatal outcome.
In Bae CHUNG ; Yong Won PARK ; Tae Yoon KIM ; Yoo Kon KIM ; Tchan Kyu PARK
Korean Journal of Obstetrics and Gynecology 1991;34(1):28-34
No abstract available.
Fetal Growth Retardation*
;
Rheology*
;
Umbilical Arteries*