1.Maternal and Child Factors Associated with Early Detection of Cerebral Palsy.
Korean Journal of Preventive Medicine 1987;20(2):312-321
To investigate the maternal and child factors associated with early detection of cerebral palsy, 74 mothers of cerebral palsy children who were born since January 1, 1980 and being treated at Taegu Rehabilitation Center for the Handicapped, Rehabilitation Center of Taegu University, St. Paul Children's House and Pusan Welfare Association of Cerebral Palsy Children were interviewed from February to April 1987. There is no association between age of child when parents noticed the child's abnormality and educational level of father but it tend to be detected earlier when education level of mother is college or above compared with high school or under. There is a trend of earlier detection of child's abnormality although statistically not significant in case father is professional or managerial worker, monthly income of father is over 610,000 won, child is first-born, age of the parents is 34 years or under, child is a boy, and child has periodic well-baby check-up. The child's abnormality is detected earlier when mothers had 7 prenatal visits or more compared with those who had 6 visits or less (P<0.05). Parents noticed the child's abnormality first in 85.1% of the case whereas doctors detected it first in 2.7% and this percentage was not different whether the child had periodic well-baby check-up or not. The first physician's diagnosis of the children was cerebral palsy in 36.5% and the rest was normal, need for observation, uncertain, etc. Parents took the child to doctor for diagnosis 2-3 months after they noticed the child's abnormality and after the child was diagnosed as cerebral palsy parents either took no therapeutic measure or brought the child to physiotherapy or acupuncture or gave herb medicine before they started specific rehabilitative therapy. For early detection of the cerebral palsy children, teaching of evaluation method for child development should be reinforced both in medical school and clinical training course and should train the specialist for diagnosis and treatment of crippling conditions. Also, public education needed for the importance of early detection of crippling conditions and currently available methods for diagnosis and treatment.
Acupuncture
;
Busan
;
Cerebral Palsy*
;
Child Development
;
Child*
;
Daegu
;
Diagnosis
;
Disabled Persons
;
Education
;
Fathers
;
Humans
;
Male
;
Mothers
;
Parents
;
Rehabilitation Centers
;
Schools, Medical
;
Specialization
2.Serum Osteocalcin Measurement by RIA in Bone Diseases Associated with Osteoporosis and Metastatic Cancer
The Journal of the Korean Orthopaedic Association 1988;23(2):600-610
Controversy persists regarding the abnormality of the bone metabolism in various bone diseases. Osteocalcin, the vitamin K-dependent protein synthesized in bone, has been shown to be a specific and sensitive marker of bone turnover in metabolic bone diseases. The author measured the serum osteocalcin level using newly developed radioimmunoassay (RIA) in the patients with osteogenesis imperfecta, metastatic bone tumor, postmenopausal osteoporosis and rheumatoid arthritis, which can be the causes of osteoporosis, and ankylosing spondylitis. The aim of this paper is to demonstrate the value of the osteocalcin measurement comparing the each data of disease group with the normal control group. The results were as followings ; 1. The mean of osteocalcin in normal Korean was 4.43±1.04 ng/ml. (4.45±1.08 ng/ml in male, 4.41±1.01 ng/ml in female). The difference between male and female was not significant statistically. 2. The osteocalcin of osteogenesis imperfects was 9.14±2.21 ng/ml, which was significant statistically, And it was thought to be the result of increasing bone turnover rate and the osteocalcin was useful as biochemical marker. 3. In metastatic bone tumor, osteocalcin was under the normal level in both untreated and treated groups, which meant low bone turnover rate or low osteoblastic activity. Osteocalcin was not a useful marker for the assessment of the effect of treatment in this study, but if the radioimmunoassay was done in the same tumor group, a valuable results could be expected. 4. Osteocalcin level in the patients with postmenopausal osteoporosis and rheumatoid arthritis was not different with normal control group and osteocalcin was not useful marker for the evaluation of the degree of osteoporosis and bone turnover. 5. Osteocalcin didn't play a role in the pathologic ossification of ankylosing spondylitis. In conclusion, the osteocalcin by radioimmunoassay can be used as a biochemical marker in metabolic bone diseases and metastatic cancer for the disgnosis and the assessment of prognosis or the effect of treatment.
Arthritis, Rheumatoid
;
Biomarkers
;
Bone Diseases
;
Bone Diseases, Metabolic
;
Bone Remodeling
;
Female
;
Humans
;
Male
;
Metabolism
;
Ossification, Heterotopic
;
Osteoblasts
;
Osteocalcin
;
Osteogenesis
;
Osteogenesis Imperfecta
;
Osteoporosis
;
Osteoporosis, Postmenopausal
;
Prognosis
;
Radioimmunoassay
;
Spondylitis, Ankylosing
;
Vitamins
3.Ganglion in extensor tendon of the hand: case report
Duke Whan CHUNG ; Jung Soo HAN ; Yong Girl LEE ; Ok Kyun AHN ; Soo Hong HAN
The Journal of the Korean Orthopaedic Association 1995;30(1):170-172
Ganglion is a common clinical entity, usually superficial in location, therefore easily diagnosed and most common tumors of the hand which represent 50 to 70% of all soft tissue tumors of the hand. The soft mucin filled cyst is attached to the adjacent underlying joint capsule, tendon, or tendon sheath. The most common ganglion is the ganglion on the dorsal side of wrist, with its origin at the scapulolunate ligament and is usually located between the extensor digitorum communis of the index finger and the extensor pollicis longus tendons. Intratendinous ganglion is very rare lesion that originates within the tendon, which has been reported 10 cases in earliest articles and 1 case in Korean article. We report one case of ganglion that arose within the extensor digitorum communis of the middle finger.
Fingers
;
Ganglion Cysts
;
Hand
;
Joint Capsule
;
Ligaments
;
Mucins
;
Tendons
;
Wrist
4.A Case of Wiskott-Aldrich Syndrome.
Byoung Geun LEE ; Soo Hee CHANG ; Soo Young CHO ; Pyoung Han HWANG ; Jung Soo KIM
Journal of the Korean Pediatric Society 1994;37(11):1615-1619
Wiskott-Aldrich Syndrome is an X-linked disorder characterized by recurrent infection, thrombocypenia and eczema. Various defects in cell-mediated immunity and deficient antibody reponse to carbohydrate antigens have been described. We experienced a case of Wiskott-Aldrich Syndrome of 28 months old male patient. He has been suffered from multiple petechiae with bleeding, recurrent pyogenic infections and generalized eczema since 3 months of age. Immunological abnormalities are as follows: 1) Serum IgM was gradually decreased, while IgA and IgE were increased. 2) Antibody response against polysaccharide antigen (PRP) was not observed after 3 times of PRPT immunization. 3) CD4/CD8 ratio was reversed (0.6). 4) Proliferative response of mononuclear cells was significantly reduced, and CMI skin test also showed negative results. A brief review of literature was made.
Antibody Formation
;
Child, Preschool
;
Eczema
;
Hemorrhage
;
Humans
;
Immunity, Cellular
;
Immunization
;
Immunoglobulin A
;
Immunoglobulin E
;
Immunoglobulin M
;
Male
;
Purpura
;
Skin Tests
;
Wiskott-Aldrich Syndrome*
5.Changes of beta-lactoglobulin Specific Immunoglobulins According to the Age and the Onset of Cow's Milk Feeding.
Jong San LEE ; Soo Young CHO ; Pyoung Han HWANG ; Soo Cheol CHO ; Jung Soo KIM
Journal of the Korean Pediatric Society 1990;33(12):1639-1646
No abstract available.
Immunoglobulins*
;
Lactoglobulins*
;
Milk*
6.Placental Transfer of Anti-H. influenzae Type b Specific IgG and Subclasses.
Soo Hee CHANG ; Moon Hwan LEE ; Pyoung Han HWANG ; Soo Chul CHO ; Jung Soo KIM
Journal of the Korean Pediatric Society 1995;38(12):1638-1644
No abstract available.
Immunoglobulin G*
;
Influenza, Human*
7.A Study of the cPR Training Course for Nurse Teachers and Ambulance Drivers.
Kyung Hee KANG ; young Soo HAN ; Jung Yun HWANG
Journal of the Korean Society of Emergency Medicine 1997;8(3):353-361
No abstract available.
Ambulances*
;
Cardiopulmonary Resuscitation*
8.Physiological Role of PGE2 and DBcAMP in Bone Cell Metabolism.
Han Jung CHAE ; Soo Wan CHAE ; Hyung Ryong KIM
Korean Journal of Immunology 1999;21(1):77-84
One of the primary functions for which bones have evolved is to act as a structural support. To achieve this, bones remodel throughout life so that their structure remains optimal for the prevailing mechanical environment. Bone remodeling consists of an initial phase of osteoclastic bone resorption followed by a bone formation period. Prostaglandins are potent regulators of bone formation and bone resorption that can have both stimulatory and inhibitory effects. Elevation of intracellular cAMP is an important intracellular signaling mechanism involved in the regulation of the expression of many proteins. In this study we examine whether PGE or DBcAMP affects osteoblastic activation or osteoclastic differentiation in mouse bone marrow cells and osteosarcoma ROS 17/2.8 cells. The effect of PGE and DBcAMP on the cell proliferation was measured by the incorporation of [3H]- thymidine into DNA. As a result, PGE2 (0.5-1 ug/ml) and DBcAMP (0.1-0.5 mM) inhibited the [3H]-thymidine incorporation into DNA in a dose dependent manner. The effect of PGE2 and DBcAMP on the induction of alkaline phosphatase (ALP) was investigated in ROS 17/2.8 cells cultured in medium containing 0.4% fetal bovine serum. PGE and DBcAMP stimulated ALP activity in the cells in a dose- dependent manner. PGE2 also increased the intracellular cAMP content in a dose- dependent fashion with a maximal effect at 0.5 ug/ml. ROS 17/2.8 cells release nitric oxide upon stimulation of PGE2 or DBcAMP with interferon-r. PGE2 and DBcAMP increase the phosphorylation level of CREB (cAMP response element binding protein) without any change on the amount of CREB protein. Also, PGE (10-6 M) and DBcAMP (10-4 M) significantly increase the generation of osteoclasts in mouse bone marrow cell culture system. In conclusion, the results of this study suggested that cAMP appears to be an important regulatory molecule in the processes of bone formation and resorption.
Alkaline Phosphatase
;
Animals
;
Bone Marrow Cells
;
Bone Remodeling
;
Bone Resorption
;
Bucladesine*
;
Cell Proliferation
;
Cyclic AMP Response Element-Binding Protein
;
Dinoprostone*
;
DNA
;
Metabolism*
;
Mice
;
Nitric Oxide
;
Osteoblasts
;
Osteoclasts
;
Osteogenesis
;
Osteosarcoma
;
Phosphorylation
;
Prostaglandins
;
Prostaglandins E
;
Response Elements
;
Thymidine
9.Effect of surface contamination on the transverse strength of the relined denture.
Jeong Hyun KIM ; Jung Soo BAE ; Dong Hoo HAN
The Journal of Korean Academy of Prosthodontics 1993;31(1):11-18
No abstract available.
Dentures*
10.Shear bond strength of porcelain repair resins to nonprecious ceramo-metal alloy.
Joon Young ANN ; Jung Soo BAE ; Dong Hoo HAN
The Journal of Korean Academy of Prosthodontics 1991;29(2):195-209
No abstract available.
Alloys*
;
Dental Porcelain*