1.An Experimental Study on Effects of Renal Papillectomy and Partial Ureteral Ligation on the Kidney.
Korean Journal of Urology 1974;15(2):65-76
Necrosis of the papilla and chronic interstitial nephritis of the renal cortex are the two renal 1esions most commonly. described in cases of analgesic nephropathy. Some authors believed that the necrosis of the papilla was secondary to the cortical changes by which fibrosis of the cortex produced ischemia of papilla and necrosis. However, other authors have suggested that the pathogenesis is, in fact, the reverse and that the cortical changes in analgesic nephropathy are caused by the medullary necrosis. An experimental study was therefore undertaken to clarify this problem and also to determine the influence of increased intrapelvic pressure on the postpapillectomy renal alterations. Followings are the results: 1. In 'the group having renal papillectomy, marked tubular dilatation and interstitial edema of the medulla are prominent changes upto two weeks after removal of the papilla. Tubules are usu. ally filled with various casts. After three weeks, there starts the tubular atrophy and interstitial fibrosis with mil infiltration of inflammatory cells. The tubular atrophy and renal scarring become much severe and diffuse six weeks after papillectomy. but glomeruli remain relatively intact. 2. The degree of tubular changes and parenchymal scarring are assumed influential to the size of removed papilla. The tubular atrophy is prominent in distal convoluted tubules and collecting tubules, and the interstitial changes extend from the medulla to the cortex in the late stage. 3. Focal or scattered depositions of amorphous calcium or calcium oxalate are found in about one fourth of cases. 4. In the group having partial ureteral ligation a week after renal papillectomy, the tubular and interstitial changes appear earlier and are more remarkable than those of papillectomy alone. The inflammatory reaction is also more prominent, and conglomeration of glomerulus is noted in some instances of the later stage. The form of the renal scarring found in this experimental study closely resembles that seen in analgesic nephropathy in man. This findings support the view that the cortical lesions in analgesic nephropathy develop as a direct consequence of papillary necrosis and additional ureteral ligation enhances interstitial nephritic process. It is possible that the tubular atrophy and interstitial edema that develop shortly after removal of the papilla may produce cortical changes.
Atrophy
;
Calcium
;
Calcium Oxalate
;
Cicatrix
;
Dilatation
;
Edema
;
Fibrosis
;
Ischemia
;
Kidney*
;
Ligation*
;
Necrosis
;
Nephritis, Interstitial
;
Ureter*
2.Can PSA Density and Parameters Derived from Biopsy Specimens Predict Bone Scan Evidence of Metastases in Newly Diagnosed Prostate Cancer?.
Seong Soo JEON ; Han Yong CHOI ; Soo Eung CHAI
Korean Journal of Urology 2000;41(8):925-932
No abstract available.
Biopsy*
;
Neoplasm Metastasis*
;
Prostate*
;
Prostatic Neoplasms*
3.Primary Carcinoma of the Ureter: Report of Two Cases.
Ho Youn LEE ; Soo Eung CHOI ; Tai Jin KIM
Korean Journal of Urology 1975;16(1):63-67
Two cases of primary carcinoma of the ureter were reported with review of the literatures.
Ureter*
4.Cytogenetic studies of 384 couples with recurrent abortion.
Soo Kyung CHOI ; Eung Ki MIN ; Sung Il ROH ; Yong Kyun PAIK ; Myung Soo LYU
Korean Journal of Fertility and Sterility 1991;18(2):223-231
No abstract available.
Abortion, Habitual*
;
Cytogenetics*
;
Family Characteristics*
;
Female
;
Pregnancy
5.The Usefulness of Endo-rectal Coil MRI in the Staging of Clinically Localized Prostate Cancer.
Eun Tak KIM ; Seong Soo JEON ; Soo Eung CHAI ; Bo Hyun KIM ; Han Yong CHOI
Korean Journal of Urology 2001;42(5):500-505
PURPOSE: We evaluated the ability of endo-rectal coil MRI (ER-MRI) to predict the local pathological stage of prostate cancer prior to radical prostatectomy and compared the results with those of transrectal ultrasonography (TRUS). MATERIALS AND METHODS: ER-MRI using high field magnets (1.5 Tesla) were performed in 22 patients (mean age 62.8 years, range 51-73) with clinically localized prostate cancer before radical prostatectomy. Of the 22 patients, 17 patients were also assessed by TRUS. The results of the imaging techniques were compared with the post-operative histopathological findings. As one patient with pelvic lymph node metastasis, which was detected on frozen-section examination during surgery, was spared radical prostatectomy, the final evaluation included 21 patients. RESULTS: DSeven of the 21 patients (33%) were found to have extraprostatic extension (EPE), and 5 had seminal vesicle invasion (SVI). The sensitivity and specificity for diagnosing EPE using ER-MRI were 62.5% and 84.6%, respectively, and 16.7% and 100% with TRUS. The sensitivity and specificity for diagnosing SVI were 80.0% and 93.8%, respectively with ER-MRI, and 0% and 92.3% with TRUS. The accuracy of predicting SVI was 90.5% with ER-MRI compared to 70.6% with TRUS. CONCLUSIONS: ER-MRI was significantly better than TRUS for determining the local extent of prostatic cancer and for prediction of SVI in the preoperative staging of clinically localized prostate cancer.
Humans
;
Lymph Nodes
;
Magnetic Resonance Imaging*
;
Neoplasm Metastasis
;
Prostate*
;
Prostatectomy
;
Prostatic Neoplasms*
;
Seminal Vesicles
;
Sensitivity and Specificity
;
Ultrasonography
6.Clinical Study of ZalsmingR on Xerosis and Pruritus.
Soo Jung KIM ; In Wook LEE ; Eung Ho CHOI ; Won Soo LEE ; Sung Ku AHN
Korean Journal of Dermatology 1997;35(3):418-423
BACKGROUND: Xerosis is a relatively common disorder, especially in the elderly. The condition is characterized by fine scaling and is associated with generalized pruritus. OBJECTIVE: The purpose of this study was to evaluate the clinical efficacy, safety and tolerability of Zalsming cream in patients with xerosis and pruritus. METHODS: Thirty patients were treated with Zalsming cream. Clinical efficacy, as measured by the score of subjective symptom and objective signs, transepidermal water loss(TEWL) and electron microscopic finding, were asessed at 2, 4, and 6 weeks after topical application of the cream. RESULTS: The scores of clinical signs and TEWL showed statistically significant improvements. No one developed any local or systemic side effects. CONCLUSION: Topical application of Zalsming cream was found to be effective and safe for patients suffering from xerosis and pruritus.
Aged
;
Humans
;
Pruritus*
7.Eosinophilic Cystitis.
Soo Eung CHOI ; Hi Suck CHOI ; Dai Hee KWAK ; Kun Weon CHOO
Korean Journal of Urology 1967;8(2):127-129
Eosinophilic cystitis is a baffling rarity impossible to distinguish grossly from bladder tumor. It is characterized by vesical irritability, hematuria and eosinophilia. The etiology is unknown. Authors have found only 7 cases in the literature and present one case which was mimicking papillary carcinoma. Patient 35 years-old married man, was admitted to Seoul National University Hospital on March 13. 1967. with a one-week history of hematuria, urgency, frequency and dysuria. Physical examination was negative. Hemograms showed normal except eosinophilia of 10% to 16%. Urinalysis showed one plus proteinuria, many red cells and 5 to 6 white cells per high power field. An excretory urogram displayed essentially normal. At cystoscopy marked bullous edema on entire bladder wall and large polypoid lesion in anterior wall were noted. Punch biopsy was done and it revealed mild degree transitional cell carcinoma of the bladder. He underwent bilateral cutaneoureteroetomy and cystectomy. The surgical specimen, however, showed no malignant lesion but diffuse eosinophilic cystitis.
Adult
;
Biopsy
;
Carcinoma, Papillary
;
Carcinoma, Transitional Cell
;
Cystectomy
;
Cystitis*
;
Cystoscopy
;
Dysuria
;
Edema
;
Eosinophilia
;
Eosinophils*
;
Hematuria
;
Humans
;
Physical Examination
;
Proteinuria
;
Seoul
;
Urinalysis
;
Urinary Bladder
;
Urinary Bladder Neoplasms
8.Longitudinal Melanonychia due to Candida Species.
In Wook LEE ; Eung Ho CHOI ; Won Soo LEE ; Seung Hun LEE ; Sung Ku AHN
Annals of Dermatology 1998;10(4):281-284
A 55-year-old Korean female patient who presented with longitudinal black pigmentation affecting the right thumbnail is described. Direct microscopic examination of nail tissue in 15% potassium hydroxide and cultures on Sabourauds glucose agar revealed Candida species. Cardida species as a cause of longitudinal melanonychia has, to our knowledge, been described only once in the literature. Our case may be the second one.
Agar
;
Candida*
;
Female
;
Glucose
;
Humans
;
Middle Aged
;
Pigmentation
;
Potassium
9.A Case of Multiple Trichilemmal Cysts.
Hae Shin CHUNG ; Nam Ho LEE ; Eung Ho CHOI ; Won Soo LEE ; Sung Ku AHN
Annals of Dermatology 1997;9(3):228-230
A case of multiple trichilemmal cysts (TC) is presented. TC is known to be a kind of keratinous cyst with lining cells showing trichilemmal keratiniration. A 63-year-old female patient presented with a 30 year duration of increasing in size and number of twenty five nodular lesions on the scalp. All twenty five TC on the scalp were totally excised and examined microscopically. However, the evidence of proliferation or malignant change like the previous case reports was not found in our case.
Female
;
Humans
;
Middle Aged
;
Scalp
10.Electron Microscopic and Immunohistochemical Comparative Studies of Bullous Congenital Ichthyosiform Erythroderma and Epidermal Nevus Histologically Showing Epidermolytic Hyperkeratosis.
Joon CHUNG ; Sung Ku AHN ; Eung Ho CHOI ; Won Soo LEE
Korean Journal of Dermatology 1995;33(3):413-420
BACKGROUND: Although the histologic picture of epidermolytic hyperkeratosis is diagnostic for bullous congenital ichthyosiform erythrokerma (BCIE), it is not specific for it. It is found also in several other conditions, that is, linear epidermal nevus, epidermolytic keratisis palmaris et plantaris and epidermolytic acnthoma. Among these, BCIE is caused by mutations of the defferentiation s0pecific keratins K1 and K1-. These mutations produce a weakened cytoskeleton that is prone to collapse resulting I cell fragility and lysis. But the pathogenesis of epidermal nevus showing the similar histologic feature with BCIE is not known. OBJECTIVE: The purpose of our study is to conpare the electron microscopic picture and the immunohistochemical features, and to find the possible pathogenesis of both diseases. METHODS: We evaluated the clinical, histopathologic nd electron microscopic features of 5 BCIE cases and 14 epidermal nevus cases which were histologically diagnosed with epidermolytic hyperkeratosis at the department of dermatology at Wonju Christian Hospital, Shinchon Severance Hospital and Yongdong Severance Hospital, from January 1981 to June 1994. The immunohistochemical staining(PAP method) using monoclonal antibody against cytokeratin was performed on BCIE and epidermal nevus. RESULTS: Light microscopy of both BCIE and epidermal nevus showed the same histologic changes including hyperkeratosis, increased keratohyaline granules, acanthosis and perinuclear vacuolization of upper malpighia layer. Electron mioroscopic findings in both diseases were similar. Aggregation of tonofilaments is noted in the squamous cells, but is not evident in basal cells.In immunohistochemical study of both diseases, 34betaE12 is stained in the whole epidermis and is stuonger ex0ressed in the basal layer tan suprabasal layers. LP34 staining is evident in suprabasal cell layers up to the cornified cell layer. CONCLUSION: Electron microscopy and immunohistochemical study of both diseases showed the same finding. We thind that a defect in the differentiation specific keratins, K1 and K10 is perhaps involved in epidermal nevus histologically showing epidermolytic hyperkeratosis as in BCIE.
Cytoskeleton
;
Dermatology
;
Epidermis
;
Gangwon-do
;
Hyperkeratosis, Epidermolytic*
;
Intermediate Filaments
;
Keratins
;
Microscopy
;
Microscopy, Electron
;
Nevus*
;
Triacetoneamine-N-Oxyl